ROC method for early detection of disease

ABSTRACT

A method of assessing risk of an individual for a disease is disclosed. A level of a marker for the disease is detected, and the risk of disease is computed from a statistical analysis of the marker level distributions for tested normal and diseased populations, using multivariate distributions. The computed risk is compared to thresholds to triage the individual into a normal, borderline, or elevated risk group, and a course of action based on the risk group is determined. Memory storing a program for execution on a data processing system, as well as a computer system comprising said memory is also disclosed, the memory comprising a receiver for signals representative of levels of a marker for the disease; a central procesing unit for computing risk of disease from one or more levels of the marker, and for comparing the computed risk to thresholds to triage the individual; and storage medium for the marker levels for subsequent computations of risk of disease.

GOVERNMENT FUNDING

This invention was made with Government support under contract number CA 56793 awarded by the National Institutes of Health. The United States Government has certain rights in this invention.

RELATED APPLICATIONS

The current application is a Continuation-in-Part (CIP) application of the provisional application, U.S. Ser. No. 60/003,601, filed Sep. 12, 1995, the entire teachings of which are hereby incorporated by reference.

RELATED APPLICATIONS

The current application is a Continuation-in-Part (CIP) application of the provisional application, U.S. Ser. No. 60/003,601, filed Sep. 12, 1995, the entire teachings of which are hereby incorporated by reference.

BACKGROUND OF THE INVENTION

Ovarian cancer is the leading cause of death from gynecologic malignancy among women in the United States, and at most ages is responsible for more deaths than all other gynecologic cancers combined (Cramer, D., "Epidemiology of Gynecologic Cancer", p. 80, in Gynecologic Oncology, 2d ed., (R. C. Knapp and R. S. Berkowitz, eds.), McGraw Hill, New York, 1993)). Annual U.S. incidence and mortality are 26,600 and 14,800, respectively (Silverberg, Calif.: A cancer journal for physicians 44:4-8 (1994)). The age specific incidence rises sharply after 50 years of age (Cramer, D., p. 80 of Gynecologic Oncology, 2d ed., (R. C. Knapp and R. S. Berkowitz, eds.), McGraw Hill, New York, 1993)). More than 70% of cases present in late stage (Piver, M. S. et al., "Ovarian Cancer", p. 253, in Gynecologic Oncology, 2d ed., (R. C. Knapp and R. S. Berkowitz, eds.), McGraw Hill, New York, 1993)) and consequently have poor prognosis. In such cases most women die of the disease. Therapeutic advances have had negligible impact on the overall survival rate during the past thirty years. However, if cancer is detected in early stage before dissemination of the disease, the five year survival rate is over 90% (Young, R. C. et al., N. Engl. J. Med. 322:1070-1073 (1990)). Furthermore, recent genetic research on ovarian cancer provides evidence of a unifocal origin (Mok, C. H. et al., Cancer Research 52:5119-5122 (1992)). These observations make early detection of ovarian cancer through a mass screening program of postmenopausal woman an attractive method for reducing mortality due to ovarian cancer.

Invasive surgery is the only definitive method of diagnosis for ovarian cancer. Nevertheless, most epithelial ovarian malignancies shed an antigenic determinant into the blood that is detectable using the CA125 radioimmunoassay (RIA) (Bast, R. C. Jr. et al., N. Engl. J. Med. 309:883-887 (1983); Klug, T. L. et al., Cancer Res. 44:883-887 (1984)). In normal populations, CA 125 levels are rarely elevated (Jacobs, I. et al., submitted 1992; Zurawski, V. R. Jr., Obstet Gynecol. 69:606-611 (1987)); however, CA 125 levels have been elevated prior to clinical detection of ovarian cancer (Bast, R. C. Jr. et al., Gynecol.Oncol. 22:115-120 (1984); Zurawski, V. R. Jr., et al., Int. J. Cancer 42: 677-680 (1988)). CA125 levels correlate with-tumor volume (Zurawski, V. R. et al., Gynecol. Oncol. 30:7-14 (1988)). Progressively higher levels of CA 125 are associated with more advanced disease, and subsequent lower levels with absence of the disease post-operatively. A level of 35 U/ml CA125 has been used to evaluate patients with demonstrable cancer (Bast, R. C. Jr. et al., Engl. J. Med. 309:169-171 (1983)). Levels of 30 U/ml to 35 U/ml have been used in retrospective and prospective studies of the incidence of ovarian cancer (Zurawski, V. R. Jr. et al., Gynecol. Oncol 36:299-305 (1990); Einhorn, N. et al., Obstet. Gynecol. 80:14-18 (1992)). Due to the low rate of occurrence of ovarian cancer, the positive predictive value of these CA125 reference levels for the presence of ovarian cancer are less than 2%. However, a high positive predictive value is necessary for an early detection program of ovarian cancer, because of the invasive nature of the surgery necessary for biopsy or removal of an ovary. Literature has suggested a minimum required positive predictive value of 10% (Jacobs, I. and Best, R., Human Reproduction, 4:1-12 (1989)). Thus, early detection of ovarian cancer with the CA125 assay has been criticized as ineffective. A need remains for an effective method for evaluating individuals at risk for ovarian cancer, in order to detect the disease in its early stages and reduce the rate of mortality due to ovarian cancer.

SUMMARY OF THE INVENTION

In accordance with the present invention a method of assessing the risk of an individual for a disease includes detecting a level of one or more markers for the disease in a sample from the individual, and computing risk of disease from detected levels of the markers. The risk of disease is computed based on a statistical analysis of multivariate marker level distributions for tested normal and diseased populations. The marker is a marker for which the level changes exponentially over time, so that the multivariate distributions can be determined from the slope and intercept of the log of detected marker levels. Random draws using Gibbs' sampling can be used to compute average densities in the multivariate distributions. Risk of disease is the product of an odds factor (computed as the ratio of the density from the disease population distribution to the density from the normal population distribution) and an estimate of prior odds of disease. A time correlation component can be added to a linear regression model of marker levels in calculation of the risk of disease.

The method is iterative in that the risk is recomputed with each serial test of a marker level. A course of action is determined for the individual, based on the computed or recomputed risk. The computed or recomputed risk is compared to thresholds to triage the individual into a normal, borderline, or elevated risk group, and a course of action based on the risk group is determined. Individuals triaged into the "normal" risk group are subjected to retesting at a routine screening interval. Individuals triaged into the "borderline" risk group are subjected to more frequent marker level measurements, at a retest interval that is less than that for those in the normal risk group; the interval between marker level measurements is inversely related to the computed risk. Individuals triaged into the "elevated" risk group are subjected to a secondary test, using a second line early detection modality which is usually more expensive than the first line modality test. Those triaged into the "elevated" risk group can also be subjected to retesting of the marker level. If results of a secondary test are normal, the future course of action is based on the recomputed risk; if the results of the secondary test are abnormal, the future course of action is surgery; and if the results of the secondary test are equivocal, the secondary test is repeated and a course of action is determined based on the results of the repeated secondary test or on the recomputed risk.

In a preferred embodiment, the individual is a postmenopausal woman, the disease is ovarian cancer, the marker is CA125, and the secondary test is an ultrasonographic test. In this embodiment, the "normal" risk group includes those with a calculated risk of ovarian cancer (ROC) less than or equal to 0.05%; the "borderline" risk group includes those with a calculated ROC greater than 0.05% but less than 4.0%; and the "elevated" risk group includes those with a calculated ROC greater than or equal to 4.0%.

In accordance with one embodiment of the current invention, memory storing a program for execution on a data processing system is provided, the memory comprising a receiver for signals representative of marker levels for a disease, a central processing unit (CPU) for computing the risk of disease based on one or more levels of the marker or markers and for comparing the computed risk to thresholds to triage the individual into risk groups, and a storage medium for the marker levels, to facilitate iterative computation of the risk. The memory can create a bar graph display indicating the computed risk, showing green when the risk is less than the normal threshold, yellow if the risk is between the borderline thresholds, and red when the risk is greater than the elevated threshold. In accordance with another embodiment, a computer system is provided which comprises an input device for receiving marker levels, a display for displaying risk of disease and courses of action, and memory as described above.

In the current invention, a marker level corresponding to the lowest borderline risk can be set much lower than a standard reference level, since the course of action for an individual with borderline risk is a cost-effective retest of a marker level, rather than a more expensive second line modality. The methods of the current invention have an increased the positive predictive value, compared to previous methods. For ovarian cancer, the positive predictive value of the current method is approximately 16%, which is an eightfold increase over previous methods. The increased positive predictive value of the methods of the invention render feasible the widescale screening of individuals for disease, thereby increasing the early detection of disease and reducing mortality due to the disease.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graphic depiction of representative CA125 marker levels for an individual in the "normal" population (no ovarian cancer) and an individual in the "diseased" population (ovarian cancer).

FIG. 2 is a graphic representation of a linear regression of the log(CA125) level over time for an individual in the "diseased" population (ovarian cancer).

FIG. 3 is a series of graphs, individually labelled as 3A, 3B, 3C and 3D, depicting CA125 levels in women with ovarian cancer (3A), other gynecological cancer (3B), breast cancer (3C), and other cancer (3D). CA125 levels were plotted on a logarithmic scale, and the time axis was specified in months.

FIG. 4 is a series of graphs, individually labelled as 4A, 4B, 4C and 4D, depicting CA125 levels in women with ovarian cancer (4A), benign gynecologic disease (4B), non-gynecologic disease (4C), or no disease (4D). CA125 levels were plotted on a logarithmic scale, and the time axis was specified in months.

FIG. 5 is a graphic representation of a multivariate distribution of data points for slope and intercept calculcated for individuals in normal (women without ovarian cancer) and diseased (women with ovarian cancer) populations.

FIG. 6 is a flow chart of the appropriate courses of action based on the assessment of the risk of ovarian cancer.

FIG. 7 is a graphic representation of the variability in marker levels as a function of time. The high slope at point X is due to short term and assay fluctuation.

FIG. 8A is a graphic representation of the early detection of disease in the method of the invention, as compared with previous methods.

FIG. 8B is a graphic representation of the change in ROC status for the individuals depicted in FIG. 8A.

FIG. 9 is a flow chart for the program stored in memory for execution on a data processing system, for assessing the risk of a woman for ovarian cancer.

FIG. 10 is a diagram for the computer system, comprising memory storing a program for execution, for assessing the risk of a woman for ovarian cancer.

DETAILED DESCRIPTION OF THE INVENTION

The risk of ovarian cancer (ROC) is assessed for a woman in the target population, using statistical analysis of detected levels of one or more markers for the woman. The target population is post-menopausal women over approximately 50 years of age, because of the increasing incidence of ovarian cancer between the ages of 50 and 75 years, and the physical changes associated with menopause. The term, "marker," as used herein, refers to a quantifiable physical characteristic which correlates with a disease state. The marker is a biochemical marker, such as a peptide, glycoprotein, carbohydrate, saccharide, or antibody. For ovarian cancer, one appropriate marker is CA125. A second appropriate marker is OVX1. The level (concentration or amount) of the marker(s) in a sample is detected (measured), using standard techniques known in the art. The sample is a physical specimen in which the marker can be detected, such as tissue, blood or serum. In a preferred embodiment, the level of CA125 in a serum sample is measured using the CA125II RIA test (Centocor, Malvern, Pa.). The level of the marker(s) is detected either once, or a plurality of times (i.e., the woman undergoes a retest for the level of the marker, usually at a subsequent date). If the marker level is detected a plurality of times, the length of time between each retest is recorded. The length of time between each retest varies from approximately 1 month to approximately 12 months.

The "risk of cancer" (ROC), or the risk of disease if the target disease is other than cancer, for the individual is computed using statistical analysis of the detected level (or levels) of the marker (or markers), relative to marker level distributions for tested normal and diseased populations. The ROC is defined as the probability that the woman has ovarian cancer, given the marker measurements, and summarizes all the marker levels (levels of a single or of multiple markers, measured once or a multitude of times) in one interpretable number. The interpretation is that, for example, among a group of women each with an ROC of 20%, it is expected that 1 woman in 5 will have ovarian cancer.

In one embodiment, the ovarian cancer marker CA125 is used. Pre-clinical (pre-symptomatic) marker level distributions for the ovarian cancer marker CA125 were obtained from normal and diseased populations. Data used to determine the pre-clinical marker level distributions included data from the Stockholm screening trial for ovarian cancer (Einhorn, N. et al., Obstet. Gynecol. 80:14-18 (1992)), and data from a screening trial with CA125 performed in Britain (Jacobs, I, et al., British Medical Journal (1993)). In a "normal" population of postmenopausal women, the CA125 marker levels are approximately 5 to 40 U/ml, and remain relatively constant over time, as shown in FIG. 1. In contrast, in a "diseased" population (women having ovarian cancer), the marker levels are approximately 5 to 1000 U/ml, and increase over time (FIG. 1). In most cases of ovarian cancer where serum levels of the marker have been measured serially before clinical detection of disease, the rise in marker levels over time has been exponential.

Because an exponential rise of CA125 over time corresponds to a linear increase of log(CA125) over time, a linear regression is fitted to each woman's log(CA125), and the slope and intercept are calculated. A representative linear regression of the log(CA125) over time is shown in FIG. 2. The intercept is the best estimate of the log(CA125) level at the time of the first serum sample, and the slope is the change from the intercept of log(CA125) within one year. Log(CA125) levels plotted against time for seven subgroups of women in the Stockholm study (ovarian cancer, other gynecological cancer, breast cancer, other cancer, benign gynecologic disease, non-gynecologic disease, and no apparent disease) verify the differential longitudinal behavior of CA125. As shown in FIGS. 3 and 4, the CA125 levels for individuals with ovarian cancer either increase sharply over time (slope) or have very high initial levels (intercept) or moderate values of both. In contrast, for those with other malignancies (FIG. 3), or benign disease or no disease (FIG. 4), most women have very low levels, or if the initial level is elevated either the level falls or remains constant over time. Very few women without ovarian cancer have rising levels over time, which enables the screening strategy based on this observation to have a very high positive predictive value.

After calculation of the slope and intercept of the log of detected marker levels over time for the individuals within the normal and diseased populations, the slopes and intercepts are plotted as points on a bivariate graph, as shown in FIG. 5. A bivariate distribution is fitted to these points, and the height of the distribution at any given location is the density of individuals in the population having that particular slope and intercept.

The distribution of slopes and intercepts is used to calculate the probability of ovarian cancer. The probability of ovarian cancer algorithm was developed by application of Bayes' Theorem (Press, S. J., Bayesian Statistics, Wiley, N.Y., 1993), assuming: (i) a bivariate Normal distribution for the slope and intercept in women without ovarian cancer (the "normal" population), (ii) a separate bivariate Normal distribution for the slope and intercept in woman with ovarian cancer (the "diseased" population), and (iii) a prior probability of ovarian cancer based on the known incidence at a given age.

To determine the probability of ovarian cancer for a woman of unknown status, the marker level for the woman is detected, and the slope and intercept for her detected marker level is computed and plotted as the test value. The "odds factor" for woman of unknown status determines how likely the test value (i.e., the estimated slope and intercept of a woman of unknown status) belongs to the group represented in the multivariate scatter plot of slope versus intercept by the cluster of points from the normal population, or from the diseased population. The "odds factor" is thus calculated as the ratio of height of distribution from the normal population, divided by the height of the distribution from the diseased population, for the test value.

The odds factor for an individual i at time t is:

     C.sub.ti |V=ν,X.sub.i,β.sub.vi !˜N(X.sub.vi β.sub.vi, σ.sup.2)                             (1)

     μ.sub.iν |β.sub.νO,Σ.sub.ν !˜N(β.sub.νO,Σ.sub.ν)              (2)

Where V: indicator for ovarian cancer (V=0: no cancer V=1: has cancer); C_(u) :CA125 levels (log); and X_(i) :time (months).

Because the distribution representing the disease population is much smaller than the distribution representing the normal population, an adjustment to the odds factor is made by calculating the "posterior odds". The odds of ovarian cancer, also known as the "posterior odds" (posterior to measurement of the marker level) is calculated as the product of the odds factor and the prior odds. The "prior odds" for the woman of unknown status is determined based on well known epidemiological data of the risk of ovarian cancer for a particular age. Family history of ovarian cancer, as well as other extrinsic risk factors, can also be factored into the prior odds.

The posterior odds are then readily converted to the risk of ovarian cancer, using the formula relating probability (measured in percent) and odds:

    ROC=100 * posteror odds/(posterior odds+1)                 (3)

Thus, calculation of the ROC can be summarized by the following formula:

    ROC=100*P V=1|C.sub.t,A!                          (4)

where V: indicator for ovarian cancer (v=0: no cancer, v=1: has cancer); C: CA125 levels (vector-log of levels); t: times of sample (vector); and A: current age.

The calculation of the risk of cancer described above uses a multivariate distribution based on two factors: slope and intercept, calculated from levels of the marker and time. Additional factors can be brought into the calculation. For example, higher order multivariate distributions can be generated by detection of plural markers (for example, CA125 and OVX1 for ovarian cancer would result in a four-variate distribution).

To account for further sources of uncertainty, other elements can be factored into the calculation of the ROC. For example, the uncertainty in the means and standard deviations for the distributions representing the normal and diseased populations can be factored into the calculation of the odds factor. Accounting for this uncertainty will more accuragely triage the individuals tested. To account for the uncertainty in the parameters of the distributions, random draws from the posterior distribution of the parameters can be obtained by Gibbs' sampling, a technique well known in the art (Gelfand, A. E., and A. F. M. Smith, J. Am. Statistical Assoc. 85(410):398 (1990)). Random draws used are listed in Table 2 below. Each row describes a distribution for the normal and the disease populations. Each row consists of five values: an intercept from the normal population (first column); a slope from the normal population (second column); an intercept from the disease population (third column); a slope from the disease population (fourth column); and the variance about the regression line (σ²) (fifth column). Given the serum levels of the marker(s) and the time intervals between measurements for an individual whose risk is being evaluated, the density specified by a row is calculated for both the diseased and normal populations. The densities over the rows are averaged, and the ratio of the average density for the normal population to the average density for the diseased population gives the final odds factor.

Using these random draws, the odds factor factor for an individual, given new data C_(it) are thus calculated as follows:

    Each draw of σ.sup.2, (β.sub.0ν,Σ.sub.ν,ν=0,1) One draw β*.sub.iν ˜N(B.sub.0ν,Σν),ν=0,1 (5)

    Sum likelihood L.sub.ν of C*.sub.it ˜N(X*.sub.i β*.sub.ν, σ.sup.2)                                            (6)

    Odds factor=L.sub.O /L.sub.1                               (7)

Alternatively or in addition, a linear regression model can be expanded to include time correlation between residuals of the serum levels within a person (Jones, R. H., Longitudinal Data with Serial Correlation (Chapman and Hall, 1993)), or a skewed bivariate distribution could be used to account for a skewed distribution of the slope and intercept. This generalizes the bivariate normal distribution and allows for skewness in the distributions of the slope and intercept.

FIG. 6 sets forth a flow chart of the appropriate courses of action based on the assessment of the risk of ovarian cancer. Once a marker level is determined at 20, the ROC is calculated (22). The individual is then triaged into one of three risk groups: normal, borderline, and elevated. Triage is based on threshold ROC values. Thresholds for ovarian cancer are set forth in Table 1.

                  TABLE 1                                                          ______________________________________                                         Risk Group Thresholds                                                          Risk Group   Threshold                                                         ______________________________________                                         Normal       ROC ≦ 0.05                                                 Borderline   0.05 ≦                                                                               ROC < 4.0                                            Elevated     4.0 ≦ ROC                                                  ______________________________________                                    

Women with a computed ROC that is less than or equal to 0.05% are triaged into the "normal" risk group (24); those with a computed ROC that is greater than 0.05% but less than 4.0% are triaged into the "borderline" risk group (28); and those with a computed ROC that is greater than or equal to 4.0% are triaged into the "elevated" risk group (32).

Once an individual is triaged into a particular risk group, a course of action can be determined. For individuals triaged into the "normal" risk group, the course of action is a retest of the level of the marker at a routine screening interval (26). A "routine screening interval" is the conventional length of time between examination and/or testing. For ovarian cancer, the measurement of the marker level can be performed concurrently with an annual gynecologic exam; thus, the "routine screening interval" is typically one year. Alternatively, the routine screening interval can be set for a shorter time interval (e.g., biannually), or a longer time interval. Longer time intervals may also result from individual delay in seeking routine examination.

For individuals triaged into the "borderline" risk group, the course of action is a retest (30) at a "retest interval," which is an interval that is substantially less than a routine screening interval. The threshold between "normal" and "borderline" (here, greater than 0.05%) is set to statistically require between 5% and 25%, preferably 15%, of a tested population to retest, as this was determined by clinical experience to be a reasonable but small fraction of the screened population to request returning for a subsequent sample before the routine screening interval. Preferably, the length of the retest interval is inversely related to the ROC, and varies between one and six months. For an ROC of 4%, the corresponding retest interval is one month; for an ROC of 0.05%, the corresponding retest interval is six months. ROC levels between these two thresholds are linearly interpolated on the log(ROC) scale. The method of calculating risk utilizing the slope and intercept does not account for the interaction between time span and the variability of the assay measurement, in that high slopes can be generated over short periods of time simply by assay fluctuations. As shown in FIG. 7, the slope can vary considerably over a short time frame, yet remain relatively constant over a longer time frame. Thus, it is important to set the retest interval to a large enough interval (for example, one month for an ROC of 4%) to minimize the possibility that a high slope is due simply to individual variation. At the same time, the aim of screening is to detect the disease in the early stage, so the retest interval should be a short enough interval (for example, six months for an ROC of 0.05%) to detect a high proportion of disease in early stage. The current method approximates the optimal balance between these two compeeting aims.

Upon retesting of the individual, the ROC is again calculated (22), and the individual is again triaged into one of the three risk groups. The course of action for an individual triaged into the borderline group depends on whether the ROC upon retesting increases or decreases past the thresholds for the group. If the ROC decreases such that the individual is triaged into the normal risk group upon retesting (24), then the course of action is the same as that for any individual triaged into the "normal" risk group: a retest of the level of the marker at the routine screening interval (26). If the ROC increases such that the individual is triaged into the "elevated" risk group upon retesting (32), then the course of action is the same as that for an individual triaged into the "elevated" risk group. If the ROC remains sufficiently constant such that the individual is triaged again into the "borderline" risk group (28), the retest interval is recalculated and the individual subjected to another retest of the marker level at the recomputed interval (30). The number of iterations wherein an individual is triaged into the "borderline" risk group is preferably limited to five, to avoid anxiety associated with repeat testing. After the fifth iteration with a borderline ROC level, the individual is treated as if she were triaged into the "elevated" risk group.

For individuals triaged into the "elevated" risk group (32), the course of action is subjecting the woman to a second line early detection modality to determine likelihood of presence of the disease (34). The threshold between "borderline" and "elevated" (here, greater than 4%) is set to statistically require between 0.5% and 2.5%, preferably 1.5%, of a tested population to undergo a test using a second line early detection modality, as this was determined by clinical experience to be a reasonable but small fraction of the screened population to subject to the second line early detection modality. It is relatively small yet balances the cost of the second line early detection modality and sensitivity. The thresholds between "normal" and "borderline", and between "borderline" and "elevated", can be lowered to improve the sensitivity of the screening program, or raised to reduce the cost associated with subsequent testing, at the discretion of an implementor of this approach to screening.

Appropriate second line early detection modalities (herein referred to as "secondary tests") for ovarian cancer include pelvic ultrasonographic examination, by transvaginal sonography (TVS); transabdominal sonography (TAS); and magnetic resonance imaging (MRI). TVS is the preferred second line modality for ovarian cancer. At the time of the secondary test, a retest of the marker level can also be conducted. Based upon the results of the secondary test and the retest of the marker level, the individual is again triaged into one of the three risk groups. If the result of the secondary test is normal (36), and the ROC is less than 20% (38), then course of action is retest of the marker level (30), recalculation of the ROC and triage of the individual into one of the three risk categories (22), as above. If the result of the secondary test is normal (36), yet the recalculated ROC is greater than 20% (40), then the appropriate course of action is surgery (50). If the result of the secondary test is abnormal (48) (for example, examination by ultrasound reveals an enlarged ovarian volume), the appropriate course of action is surgery (50). If the result of the secondary test is equivocal (42) (for example, examination by ultrasound reveals that the ovary volume is not abnormal, yet has suspicious morphology), then two subsequent repeats of the secondary test are performed, at intervals of approximately six weeks. If both of the repeat secondary tests are normal (44), the appropriate course of action is the same as if the original secondary test result was normal (36), as above. If the recalculated ROC is greater than 12% (46), or either of the repeat secondary tests is equivocal or abnormal (46), then the appropriate future action is surgery (50).

Previous approaches to early detection of ovarian cancer based on marker level measurements specify a single reference level, above which women are called screen positive. When the marker exceeds the reference level, a more expensive, second line screening modality (such as ultrasound) is used; for this reason, the reference level is relatively high. In contrast, in the current method the subsequent action can be the less expensive, first line modality of further measurement of the marker level, with a rise in the marker level indicating the higher risk. Because the method of the invention utilizes iterative marker level measurements, the borderline level for a further measurement of the marker level can be set lower than previously used reference levels. Thus, the iterative method of the current invention allows earlier detection of cancer.

For example, FIG. 8A demonstrates that two individuals with the same initial marker level may have different disease outcomes. At an initial annual screening, individuals X and Y both have a marker level that is above the lower reference level of the current invention, yet below the standard reference level (diamond). If the standard reference level is used, individuals X and Y would both be retested at a second annual screening (squares). At that time, Y remains disease-free; however, individual X would have late-stage disease. In contrast, in the current method, both individuals X and Y are placed in the "borderline" risk group (FIG. 8B), with the resulting course of action that each is retested at the retest interval (FIG. 8A, circles). At that time, it would be noted that individual X has an increasing marker level, thereby resulting in an increased ROC (FIG. 8B), whereas individual Y has a constant or decreasing marker, resulting in a constant or lower ROC (FIG. 8B). Individual X has been triaged into the "elevated" risk group, and is referred to a second line early detection modality (FIG. 8A, triangle). Ultimately, her cancer is detected at an early stage. The method of the current invention thus detects all cases of ovarian cancer which previous approaches would detect (i.e., detection of the late-stage cancer of individual X at the second annual screening), and in addition, detects those cases which are in early stage (i.e., detection of early-stage cancer of individual X at the retest interval). Thus, the sensitivity for detection in early stage disease is increased, and mortality due to the disease is reduced.

In accordance with another embodiment of the current invention, memory storing a program for execution on a data processing system is available for assessing the risk of a woman for ovarian cancer. As shown in FIG. 9, the memory includes a receiver for signals representative of levels of a marker for ovarian cancer (50); central processing unit for computing the ROC from one or more levels of the marker (52) and for comparing the computed ROC to thresholds to triage the woman into normal, borderline or elevated risk groups (54); and a storage medium for the marker levels (56), for subsequent computations of ROC. The memory can further comprise a means for creating a bar graph display indicating the computed risk, the display being green when the risk is less than the normal threshold, yellow when the risk is between the borderline thresholds, and red when the risk is greater than the elevated threshold.

A computer system is also available, as shown in FIG. 10, comprising a keyboard input device (60) for receiving marker levels, a display (62) for displaying risk of ovarian cancer and courses of action based on the ROC, and a memory (64) as described above.

While the above discussion pertains to assessing the risk of an individual for ovarian cancer, the methods described herein are applicable to any disease for which a biological marker correlating with a disease state is available, and can be used as a diagnostic indicator for any such disease. The thresholds for the risk groups will vary, depending on the disease and the marker or markers used.

                                      TABLE 2                                      __________________________________________________________________________     1.0099                                                                             0.4795                                                                             2.6374                                                                             0.0067                                                                             0.0269                                                                               4.9954                                                                             1.9448                                                                             2.6165                                                                             0.0123                                                                             0.0305                                   0.8238                                                                             0.3206                                                                             2.6359                                                                             0.0085                                                                             0.0285                                                                               4.1167                                                                             1.6259                                                                             2.6557                                                                             0.0155                                                                             0.0291                                   1.7236                                                                             0.3530                                                                             2.6622                                                                             0.0007                                                                             0.0291                                                                               1.8513                                                                             0.9700                                                                             2.6432                                                                             0.0119                                                                             0.0280                                   2.9772                                                                             0.9660                                                                             2.6441                                                                             0.0025                                                                             0.0302                                                                               0.4507                                                                             -0.2813                                                                            2.6559                                                                             0.0101                                                                             0.0267                                   1.7073                                                                             0.1026                                                                             2.6770                                                                             -0.0015                                                                            0.0296                                                                               -1.4399                                                                            -0.3394                                                                            2.6509                                                                             0.0090                                                                             0.0268                                   2.5688                                                                             0.4641                                                                             2.6652                                                                             0.0062                                                                             0.0281                                                                               -2.7688                                                                            1.1192                                                                             2.6542                                                                             0.0044                                                                             0.0284                                   1.7270                                                                             -0.1553                                                                            2.6381                                                                             0.0063                                                                             0.0284                                                                               1.8855                                                                             0.6877                                                                             2.6276                                                                             0.0129                                                                             0.0279                                   2.4494                                                                             -0.0452                                                                            2.6254                                                                             0.0152                                                                             0.0283                                                                               2.5110                                                                             0.3957                                                                             2.6481                                                                             0.0154                                                                             0.0273                                   2.3503                                                                             0.7394                                                                             2.6424                                                                             0.0077                                                                             0.0282                                                                               2.7140                                                                             0.3824                                                                             2.6473                                                                             0.0099                                                                             0.0284                                   1.4795                                                                             0.3209                                                                             2.6555                                                                             0.0128                                                                             0.0274                                                                               2.2289                                                                             0.2939                                                                             2.6727                                                                             0.0111                                                                             0.0275                                   3.9082                                                                             0.6031                                                                             2.6515                                                                             0.0128                                                                             0.0269                                                                               2.4482                                                                             0.0187                                                                             2.6591                                                                             0.0078                                                                             0.0281                                   1.4847                                                                             2.2387                                                                             2.6552                                                                             0.0107                                                                             0.0260                                                                               1.6324                                                                             -0.6386                                                                            2.6560                                                                             0.0098                                                                             0.0279                                   -2.1320                                                                            0.5757                                                                             2.6429                                                                             0.0058                                                                             0.0270                                                                               2.7759                                                                             0.2501                                                                             2.6485                                                                             0.0088                                                                             0.0280                                   -0.8840                                                                            0.5316                                                                             2.6611                                                                             0.0186                                                                             0.0281                                                                               5.3864                                                                             0.9579                                                                             2.6542                                                                             0.0132                                                                             0.0278                                   0.4636                                                                             1.0452                                                                             2.6475                                                                             0.0152                                                                             0.0278                                                                               4.0161                                                                             0.6088                                                                             2.6424                                                                             0.0131                                                                             0.0293                                   -1.4354                                                                            0.7765                                                                             2.6378                                                                             0.0244                                                                             0.0283                                                                               5.1315                                                                             0.0116                                                                             2.6677                                                                             0.0169                                                                             0.0291                                   1.8580                                                                             0.6886                                                                             2.6596                                                                             0.0177                                                                             0.0271                                                                               4.2429                                                                             -0.4001                                                                            2.6518                                                                             0.0231                                                                             0.0286                                   3.0502                                                                             0.2413                                                                             2.6517                                                                             0.0136                                                                             0.0274                                                                               0.9617                                                                             0.2084                                                                             2.6367                                                                             0.0193                                                                             0.0293                                   0.2088                                                                             -0.1445                                                                            2.6409                                                                             0.0067                                                                             0.0276                                                                               0.9306                                                                             0.8899                                                                             2.6500                                                                             0.0070                                                                             0.0286                                   1.8926                                                                             -1.1937                                                                            2.6429                                                                             -0.0017                                                                            0.0274                                                                               1.2297                                                                             0.2313                                                                             2.6634                                                                             -0.0036                                                                            0.0290                                   2.6553                                                                             0.5389                                                                             2.6468                                                                             0.0032                                                                             0.0282                                                                               0.4932                                                                             1.4498                                                                             2.6585                                                                             0.0041                                                                             0.0293                                   1.1740                                                                             0.2920                                                                             2.6517                                                                             0.0134                                                                             0.0280                                                                               1.3441                                                                             -0.1340                                                                            2.6459                                                                             0.0115                                                                             0.0295                                   2.6419                                                                             0.2983                                                                             2.6602                                                                             0.0192                                                                             0.0274                                                                               2.3298                                                                             0.0466                                                                             2.6647                                                                             0.0151                                                                             0.0287                                   3.1075                                                                             -0.4384                                                                            2.6562                                                                             0.0072                                                                             0.0283                                                                               2.6455                                                                             -0.7596                                                                            2.6525                                                                             0.0171                                                                             0.0290                                   4.6214                                                                             -0.5384                                                                            2.6461                                                                             0.0036                                                                             0.0283                                                                               1.2596                                                                             -0.3879                                                                            2.6617                                                                             0.0081                                                                             0.0290                                   5.3071                                                                             -0.0029                                                                            2.6673                                                                             0.0060                                                                             0.0294                                                                               2.7172                                                                             1.3295                                                                             2.6743                                                                             0.0068                                                                             0.0284                                   6.3176                                                                             -0.2133                                                                            2.6488                                                                             -0.0033                                                                            0.0297                                                                               2.1809                                                                             1.0482                                                                             2.6481                                                                             0.0134                                                                             0.0281                                   2.0984                                                                             -0.9646                                                                            2.6577                                                                             0.0078                                                                             0.0293                                                                               3.3893                                                                             -0.0240                                                                            2.6376                                                                             0.0119                                                                             0.0283                                   5.4400                                                                             -0.0767                                                                            2.6563                                                                             0.0046                                                                             0.0296                                                                               1.4319                                                                             0.3274                                                                             2.6449                                                                             0.0107                                                                             0.0289                                   2.2919                                                                             0.9984                                                                             2.6468                                                                             0.0010                                                                             0.0297                                                                               0.9632                                                                             0.7925                                                                             2.6561                                                                             0.0080                                                                             0.0283                                   0.0624                                                                             0.7756                                                                             2.6316                                                                             0.0050                                                                             0.0279                                                                               -0.0517                                                                            0.8222                                                                             2.6550                                                                             0.0049                                                                             0.0293                                   0.0903                                                                             0.6841                                                                             2.6554                                                                             0.0049                                                                             0.0281                                                                               3.4388                                                                             1.1389                                                                             2.6751                                                                             0.0103                                                                             0.0292                                   1.4539                                                                             0.7637                                                                             2.6626                                                                             0.0036                                                                             0.0270                                                                               1.4772                                                                             1.4330                                                                             2.6483                                                                             0.0078                                                                             0.0294                                   1.7765                                                                             -0.3648                                                                            2.6580                                                                             0.0147                                                                             0.0275                                                                               1.5651                                                                             2.6823                                                                             2.6431                                                                             -0.0009                                                                            0.0288                                   2.8074                                                                             0.1563                                                                             2.6773                                                                             0.0142                                                                             0.0272                                                                               2.2576                                                                             1.4773                                                                             2.6658                                                                             0.0054                                                                             0.0303                                   2.2494                                                                             -0.1657                                                                            2.6674                                                                             0.0120                                                                             0.0264                                                                               5.1376                                                                             1.5096                                                                             2.6515                                                                             -0.0030                                                                            0.0296                                   1.9571                                                                             0.3216                                                                             2.6597                                                                             0.0165                                                                             0.0273                                                                               0.2110                                                                             0.5084                                                                             2.6397                                                                             0.0070                                                                             0.0290                                   3.2765                                                                             -0.8656                                                                            2.6476                                                                             0.0178                                                                             0.0275                                                                               1.2172                                                                             -0.0667                                                                            2.6375                                                                             0.0022                                                                             0.0288                                   2.8438                                                                             -0.5374                                                                            2.6353                                                                             0.0217                                                                             0.0279                                                                               2.4474                                                                             -0.1737                                                                            2.6542                                                                             0.0004                                                                             0.0282                                   4.2653                                                                             -0.1520                                                                            2.6354                                                                             0.0262                                                                             0.0310                                                                               1.6769                                                                             0.7392                                                                             2.6566                                                                             -0.0015                                                                            0.0298                                   3.0546                                                                             -0.0148                                                                            2.6548                                                                             0.0159                                                                             0.0323                                                                               3.4623                                                                             0.7399                                                                             2.6395                                                                             0.0083                                                                             0.0292                                   3.3524                                                                             -0.2952                                                                            2.6576                                                                             0.0108                                                                             0.0328                                                                               1.2033                                                                             0.2894                                                                             2.6432                                                                             0.0116                                                                             0.0287                                   0.7209                                                                             -0.8763                                                                            2.6491                                                                             0.0141                                                                             0.0332                                                                               2.6478                                                                             -0.4033                                                                            2.6713                                                                             0.0133                                                                             0.0283                                   2.0480                                                                             0.4667                                                                             2.6483                                                                             0.0070                                                                             0.0308                                                                               2.7645                                                                             0.8763                                                                             2.6569                                                                             0.0076                                                                             0.0266                                   -2.5065                                                                            0.7837                                                                             2.6843                                                                             0.0032                                                                             0.0300                                                                               4.0696                                                                             0.1331                                                                             2.6518                                                                             0.0129                                                                             0.0269                                   1.1399                                                                             1.2462                                                                             2.6490                                                                             0.0037                                                                             0.0305                                                                               3.6954                                                                             0.0114                                                                             2.6587                                                                             0.0153                                                                             0.0269                                   1.7324                                                                             0.5309                                                                             2.6466                                                                             0.0021                                                                             0.0289                                                                               2.5230                                                                             -0.4317                                                                            2.6570                                                                             0.0175                                                                             0.0273                                   3.5020                                                                             0.0241                                                                             2.6211                                                                             0.0071                                                                             0.0294                                                                               3.3542                                                                             0.7178                                                                             2.6593                                                                             0.0206                                                                             0.0268                                   0.5020                                                                             0.1637                                                                             2.6475                                                                             0.0069                                                                             0.0284                                                                               1.3306                                                                             0.7408                                                                             2.6479                                                                             0.0186                                                                             0.0266                                   1.1781                                                                             -0.1946                                                                            2.6388                                                                             0.0098                                                                             0.0281                                                                               1.2436                                                                             1.4600                                                                             2.6311                                                                             0.0252                                                                             0.0267                                   4.3701                                                                             2.0096                                                                             2.6506                                                                             0.0108                                                                             0.0287                                                                               1.9078                                                                             1.4190                                                                             2.6502                                                                             0.0190                                                                             0.0255                                   5.3849                                                                             0.5420                                                                             2.6339                                                                             0.0211                                                                             0.0274                                                                               0.7855                                                                             1.0496                                                                             2.6676                                                                             0.0001                                                                             0.0247                                   4.0916                                                                             -0.3529                                                                            2.6531                                                                             0.0135                                                                             0.0285                                                                               -0.2603                                                                            1.4978                                                                             2.6420                                                                             0.0075                                                                             0.0238                                   5.7893                                                                             -0.4638                                                                            2.6348                                                                             0.0093                                                                             0.0268                                                                               2.6686                                                                             0.0423                                                                             2.6473                                                                             0.0139                                                                             0.0253                                   2.2090                                                                             -0.4400                                                                            2.6421                                                                             0.0098                                                                             0.0265                                                                               2.6686                                                                             0.5288                                                                             2.6571                                                                             0.0100                                                                             0.0252                                   1.6812                                                                             0.1691                                                                             2.6313                                                                             0.0113                                                                             0.0271                                                                               1.8062                                                                             2.1412                                                                             2.6542                                                                             0.0138                                                                             0.0280                                   2.9033                                                                             -0.4850                                                                            2.6392                                                                             0.0069                                                                             0.0271                                                                               3.5645                                                                             0.7435                                                                             2.6354                                                                             0.0223                                                                             0.0273                                   1.8555                                                                             -0.2973                                                                            2.6419                                                                             0.0106                                                                             0.0272                                                                               4.8631                                                                             0.9566                                                                             2.6426                                                                             0.0096                                                                             0.0266                                   1.3720                                                                             0.3154                                                                             2.6411                                                                             0.0091                                                                             0.0262                                                                               4.1168                                                                             -0.2003                                                                            2.6621                                                                             0.0048                                                                             0.0266                                   0.6551                                                                             0.6433                                                                             2.6377                                                                             0.0053                                                                             0.0266                                                                               2.3478                                                                             1.6221                                                                             2.6429                                                                             0.0100                                                                             0.0278                                   0.9892                                                                             0.4938                                                                             2.6553                                                                             0.0133                                                                             0.0253                                                                               3.2414                                                                             1.9463                                                                             2.6707                                                                             0.0052                                                                             0.0292                                   1.2561                                                                             0.4499                                                                             2.6580                                                                             0.0138                                                                             0.0263                                                                               3.5835                                                                             1.0479                                                                             2.6556                                                                             0.0087                                                                             0.0277                                   4.2230                                                                             1.6353                                                                             2.6326                                                                             0.0203                                                                             0.0257                                                                               4.2748                                                                             -1.0994                                                                            2.6608                                                                             0.0102                                                                             0.0271                                   3.4926                                                                             1.2350                                                                             2.6442                                                                             0.0396                                                                             0.0277                                                                               4.2617                                                                             -0.5831                                                                            2.6541                                                                             0.0116                                                                             0.0273                                   4.0477                                                                             1.2611                                                                             2.6328                                                                             0.0189                                                                             0.0269                                                                               2.2422                                                                             0.3819                                                                             2.6680                                                                             0.0066                                                                             0.0277                                   2.3172                                                                             -0.1990                                                                            2.6287                                                                             0.0189                                                                             0.0270                                                                               0.6645                                                                             0.7555                                                                             2.6597                                                                             0.0099                                                                             0.0290                                   1.7433                                                                             0.3250                                                                             2.6448                                                                             0.0204                                                                             0.0285                                                                               5.4454                                                                             0.2669                                                                             2.6626                                                                             0.0153                                                                             0.0284                                   1.0381                                                                             -0.7542                                                                            2.6333                                                                             0.0281                                                                             0.0281                                                                               2.0754                                                                             -0.1687                                                                            2.6377                                                                             0.0130                                                                             0.0295                                   0.0082                                                                             -0.6177                                                                            2.6549                                                                             0.0220                                                                             0.0282                                                                               1.9459                                                                             -0.6060                                                                            2.6358                                                                             0.0089                                                                             0.0289                                   3.5856                                                                             -0.0326                                                                            2.6608                                                                             0.0120                                                                             0.0266                                                                               1.2459                                                                             0.3690                                                                             2.6375                                                                             0.0189                                                                             0.0289                                   1.8890                                                                             -0.0064                                                                            2.6425                                                                             0.0123                                                                             0.0262                                                                               2.9208                                                                             -0.6669                                                                            2.6569                                                                             0.0168                                                                             0.0280                                   1.8989                                                                             0.3023                                                                             2.6335                                                                             0.0224                                                                             0.0265                                                                               2.6819                                                                             -0.6204                                                                            2.6631                                                                             0.0172                                                                             0.0265                                   1.4821                                                                             -0.0517                                                                            2.6531                                                                             0.0203                                                                             0.0271                                                                               6.2859                                                                             0.4980                                                                             2.6715                                                                             0.0082                                                                             0.0269                                   0.3669                                                                             0.6792                                                                             2.6428                                                                             0.0192                                                                             0.0265                                                                               2.7920                                                                             0.3387                                                                             2.6665                                                                             0.0035                                                                             0.0266                                   3.7105                                                                             -0.1628                                                                            2.6423                                                                             0.0077                                                                             0.0276                                                                               3.2285                                                                             0.8799                                                                             2.6462                                                                             0.0140                                                                             0.0263                                   2.8831                                                                             -0.3025                                                                            2.6526                                                                             0.0086                                                                             0.0267                                                                               5.0736                                                                             0.6056                                                                             2.6537                                                                             0.0153                                                                             0.0271                                   2.5319                                                                             -0.4989                                                                            2.6439                                                                             -0.0002                                                                            0.0264                                                                               3.4753                                                                             -0.1649                                                                            2.6475                                                                             0.0206                                                                             0.0273                                   4.0352                                                                             0.2628                                                                             2.6598                                                                             0.0072                                                                             0.0258                                                                               4.5882                                                                             -0.8294                                                                            2.6525                                                                             0.0272                                                                             0.0270                                   0.5929                                                                             -0.2826                                                                            2.6475                                                                             0.0146                                                                             0.0269                                                                               3.3924                                                                             -0.0552                                                                            2.6758                                                                             0.0199                                                                             0.0261                                   0.0431                                                                             0.8334                                                                             2.6469                                                                             0.0146                                                                             0.0250                                                                               1.9251                                                                             -0.7361                                                                            2.6480                                                                             0.0199                                                                             0.0273                                   -0.6452                                                                            0.6260                                                                             2.6509                                                                             0.0110                                                                             0.0257                                                                               -1.3261                                                                            -0.3767                                                                            2.6635                                                                             0.0237                                                                             0.0270                                   3.6289                                                                             0.2880                                                                             2.6506                                                                             0.0172                                                                             0.0249                                                                               1.8159                                                                             -0.1598                                                                            2.6504                                                                             0.0164                                                                             0.0284                                   3.1801                                                                             -0.5438                                                                            2.6472                                                                             0.0080                                                                             0.0251                                                                               4.8621                                                                             0.0865                                                                             2.6448                                                                             0.0207                                                                             0.0286                                   3.9453                                                                             -0.1008                                                                            2.6442                                                                             0.0176                                                                             0.0253                                                                               1.8508                                                                             0.8240                                                                             2.6530                                                                             0.0113                                                                             0.0293                                   2.7831                                                                             0.1908                                                                             2.6486                                                                             0.0129                                                                             0.0247                                                                               4.6145                                                                             0.2686                                                                             2.6420                                                                             0.0115                                                                             0.0280                                   2.0232                                                                             -0.2053                                                                            2.6390                                                                             0.0142                                                                             0.0255                                                                               2.1998                                                                             0.2466                                                                             2.6359                                                                             0.0215                                                                             0.0279                                   3.3969                                                                             -0.1773                                                                            2.6299                                                                             0.0229                                                                             0.0259                                                                               0.5857                                                                             0.0532                                                                             2.6520                                                                             0.0172                                                                             0.0278                                   1.3822                                                                             -0.4637                                                                            2.6452                                                                             0.0241                                                                             0.0276                                                                               1.4458                                                                             0.9532                                                                             2.6698                                                                             0.0157                                                                             0.0284                                   2.7488                                                                             -0.1874                                                                            2.6344                                                                             0.0116                                                                             0.0274                                                                               1.0942                                                                             -0.4146                                                                            2.6411                                                                             0.0238                                                                             0.0270                                   5.0651                                                                             -0.5417                                                                            2.6620                                                                             0.0059                                                                             0.0282                                                                               3.1185                                                                             -0.6195                                                                            2.6355                                                                             0.0190                                                                             0.0270                                   3.8201                                                                             -0.1818                                                                            2.6567                                                                             0.0064                                                                             0.0289                                                                               4.3734                                                                             0.9311                                                                             2.6432                                                                             0.0270                                                                             0.0263                                   7.0122                                                                             1.2360                                                                             2.6603                                                                             0.0100                                                                             0.0282                                                                               2.0681                                                                             0.1833                                                                             2.6563                                                                             0.0125                                                                             0.0280                                   0.0248                                                                             0.5870                                                                             2.6399                                                                             0.0221                                                                             0.0272                                                                               4.6253                                                                             0.1007                                                                             2.6508                                                                             0.0224                                                                             0.0280                                   -2.9624                                                                            0.7575                                                                             2.6348                                                                             0.0255                                                                             0.0285                                                                               4.6844                                                                             -0.1010                                                                            2.6379                                                                             0.0165                                                                             0.0278                                   -0.5051                                                                            0.2710                                                                             2.6454                                                                             0.0177                                                                             0.0288                                                                               5.6332                                                                             0.1337                                                                             2.6377                                                                             0.0090                                                                             0.0286                                   0.9839                                                                             -0.4375                                                                            2.6197                                                                             0.0129                                                                             0.0284                                                                               1.4749                                                                             -0.4333                                                                            2.6651                                                                             0.0005                                                                             0.0278                                   4.6789                                                                             -0.8653                                                                            2.6598                                                                             0.0052                                                                             0.0272                                                                               1.0641                                                                             2.0429                                                                             2.6611                                                                             0.0066                                                                             0.0289                                   3.2420                                                                             0.9746                                                                             2.6565                                                                             0.0070                                                                             0.0280                                                                               0.4856                                                                             0.4429                                                                             2.6540                                                                             0.0127                                                                             0.0274                                   3.2979                                                                             0.6786                                                                             2.6366                                                                             0.0131                                                                             0.0283                                                                               1.3801                                                                             0.2372                                                                             2.6421                                                                             0.0155                                                                             0.0269                                   2.2344                                                                             1.0049                                                                             2.6438                                                                             0.0133                                                                             0.0282                                                                               3.3259                                                                             -0.6361                                                                            2.6342                                                                             0.0122                                                                             0.0277                                   3.2143                                                                             2.1972                                                                             2.6580                                                                             0.0202                                                                             0.0281                                                                               1.3237                                                                             0.0111                                                                             2.6116                                                                             0.0201                                                                             0.0277                                   3.4499                                                                             1.8662                                                                             2.6447                                                                             0.0180                                                                             0.0289                                                                               -0.0109                                                                            0.4826                                                                             2.6522                                                                             0.0159                                                                             0.0273                                   3.0171                                                                             2.4353                                                                             2.6393                                                                             0.0173                                                                             0.0281                                                                               2.3904                                                                             1.5241                                                                             2.6460                                                                             0.0177                                                                             0.0274                                   3.1228                                                                             2.0866                                                                             2.6438                                                                             0.0140                                                                             0.0282                                                                               4.2128                                                                             2.2542                                                                             2.6543                                                                             0.0192                                                                             0.0268                                   2.3351                                                                             -0.5662                                                                            2.6399                                                                             0.0076                                                                             0.0283                                                                               5.3789                                                                             1.2913                                                                             2.6427                                                                             0.0195                                                                             0.0279                                   1.4037                                                                             -0.7996                                                                            2.6501                                                                             0.0047                                                                             0.0279                                                                               1.0288                                                                             0.3169                                                                             2.6447                                                                             0.0242                                                                             0.0268                                   6.1289                                                                             0.4750                                                                             2.6498                                                                             0.0113                                                                             0.0293                                                                               5.8788                                                                             1.4641                                                                             2.6556                                                                             0.0306                                                                             0.0276                                   3.2978                                                                             0.3765                                                                             2.6397                                                                             0.0254                                                                             0.0287                                                                               6.4206                                                                             0.7133                                                                             2.6488                                                                             0.0297                                                                             0.0279                                   2.8824                                                                             0.9049                                                                             2.6161                                                                             0.0271                                                                             0.0286                                                                               5.6105                                                                             0.4041                                                                             2.6477                                                                             0.0233                                                                             0.0285                                   2.2219                                                                             0.3404                                                                             2.6649                                                                             0.0203                                                                             0.0274                                                                               4.1774                                                                             0.1554                                                                             2.6651                                                                             0.0272                                                                             0.0282                                   2.1229                                                                             0.3822                                                                             2.6562                                                                             0.0213                                                                             0.0279                                                                               3.1435                                                                             0.4356                                                                             2.6643                                                                             0.0283                                                                             0.0281                                   3.2567                                                                             -0.6389                                                                            2.6457                                                                             0.0175                                                                             0.0270                                                                               3.0936                                                                             -0.8610                                                                            2.6291                                                                             0.0325                                                                             0.0276                                   3.8677                                                                             -0.4193                                                                            2.6460                                                                             0.0147                                                                             0.0273                                                                               -0.3288                                                                            0.4535                                                                             2.6334                                                                             0.0292                                                                             0.0279                                   1.3385                                                                             -0.4066                                                                            2.6378                                                                             0.0131                                                                             0.0264                                                                               3.7979                                                                             0.7429                                                                             2.6457                                                                             0.0268                                                                             0.0260                                   0.9525                                                                             1.1426                                                                             2.6501                                                                             0.0244                                                                             0.0265                                                                               3.5172                                                                             0.9505                                                                             2.6584                                                                             0.0212                                                                             0.0259                                   1.2131                                                                             1.5904                                                                             2.6407                                                                             0.0159                                                                             0.0261                                                                               7.2051                                                                             1.4102                                                                             2.6511                                                                             0.0118                                                                             0.0265                                   1.2481                                                                             1.5795                                                                             2.6437                                                                             0.0213                                                                             0.0281                                                                               2.9198                                                                             0.4142                                                                             2.6627                                                                             0.0168                                                                             0.0256                                   4.3241                                                                             0.9650                                                                             2.6151                                                                             0.0331                                                                             0.0263                                                                               2.8920                                                                             0.5096                                                                             2.6511                                                                             0.0133                                                                             0.0266                                   4.4874                                                                             -0.4599                                                                            2.6432                                                                             0.0297                                                                             0.0263                                                                               2.8603                                                                             0.3942                                                                             2.6403                                                                             0.0193                                                                             0.0275                                   5.2774                                                                             0.2012                                                                             2.6544                                                                             0.0227                                                                             0.0283                                                                               -3.8882                                                                            0.5734                                                                             2.6482                                                                             0.0100                                                                             0.0268                                   3.4734                                                                             0.8459                                                                             2.6559                                                                             0.0165                                                                             0.0276                                                                               0.4462                                                                             0.2610                                                                             2.6598                                                                             0.0129                                                                             0.0252                                   1.5196                                                                             0.1079                                                                             2.6403                                                                             0.0034                                                                             0.0264                                                                               2.0422                                                                             -0.0808                                                                            2.6427                                                                             0.0110                                                                             0.0272                                   1.4573                                                                             -0.1556                                                                            2.6529                                                                             0.0161                                                                             0.0277                                                                               3.7280                                                                             1.0772                                                                             2.6304                                                                             0.0147                                                                             0.0278                                   4.0734                                                                             -0.0146                                                                            2.6502                                                                             0.0168                                                                             0.0282                                                                               2.9593                                                                             0.5719                                                                             2.6495                                                                             0.0091                                                                             0.0278                                   5.1582                                                                             -0.1321                                                                            2.6504                                                                             0.0154                                                                             0.0276                                                                               2.9387                                                                             0.6617                                                                             2.6403                                                                             0.0049                                                                             0.0281                                   1.6174                                                                             -0.6162                                                                            2.6634                                                                             0.0190                                                                             0.0297                                                                               2.2359                                                                             0.5467                                                                             2.6424                                                                             0.0155                                                                             0.0271                                   4.0999                                                                             1.6757                                                                             2.6351                                                                             0.0164                                                                             0.0306                                                                               3.4838                                                                             0.3673                                                                             2.6402                                                                             0.0278                                                                             0.0277                                   4.6223                                                                             1.8929                                                                             2.6524                                                                             0.0149                                                                             0.0305                                                                               4.7579                                                                             1.7166                                                                             2.6621                                                                             0.0162                                                                             0.0281                                   3.0558                                                                             0.2319                                                                             2.6617                                                                             0.0224                                                                             0.0275                                                                               0.9775                                                                             0.1679                                                                             2.6546                                                                             0.0051                                                                             0.0267                                   4.2514                                                                             -1.0392                                                                            2.6753                                                                             0.0238                                                                             0.0260                                                                               3.4743                                                                             -0.0970                                                                            2.6514                                                                             0.0213                                                                             0.0267                                   2.4499                                                                             0.1913                                                                             2.6491                                                                             0.0250                                                                             0.0260                                                                               2.6520                                                                             -0.3729                                                                            2.6555                                                                             0.0200                                                                             0.0268                                   4.7913                                                                             0.5536                                                                             2.6457                                                                             0.0249                                                                             0.0263                                                                               3.4109                                                                             0.1177                                                                             2.6377                                                                             0.0144                                                                             0.0256                                   3.4071                                                                             1.2304                                                                             2.6545                                                                             0.0244                                                                             0.0277                                                                               2.2971                                                                             1.3729                                                                             2.6635                                                                             -0.0008                                                                            0.0263                                   1.2402                                                                             1.1786                                                                             2.6454                                                                             0.0178                                                                             0.0272                                                                               3.7685                                                                             -0.1694                                                                            2.6511                                                                             -0.0029                                                                            0.0269                                   0.9684                                                                             1.0373                                                                             2.6476                                                                             0.0189                                                                             0.0270                                                                               2.8279                                                                             -0.4604                                                                            2.6609                                                                             -0.0085                                                                            0.0270                                   3.4595                                                                             1.3686                                                                             2.6494                                                                             0.0205                                                                             0.0290                                                                               3.5623                                                                             -0.5980                                                                            2.6673                                                                             -0.0045                                                                            0.0268                                   2.3979                                                                             1.5256                                                                             2.6625                                                                             0.0167                                                                             0.0287                                                                               2.6882                                                                             0.0639                                                                             2.6459                                                                             0.0009                                                                             0.0261                                   1.8274                                                                             -1.2548                                                                            2.6360                                                                             0.0126                                                                             0.0275                                                                               4.5225                                                                             -0.3085                                                                            2.6536                                                                             0.0014                                                                             0.0254                                   3.0529                                                                             -0.1015                                                                            2.6466                                                                             0.0248                                                                             0.0274                                                                               3.6526                                                                             1.8264                                                                             2.6636                                                                             -0.0006                                                                            0.0265                                   4.2845                                                                             -0.9405                                                                            2.6409                                                                             0.0185                                                                             0.0267                                                                               4.6967                                                                             1.1367                                                                             2.6495                                                                             0.0121                                                                             0.0266                                   4.2576                                                                             -1.2961                                                                            2.6384                                                                             0.0098                                                                             0.0263                                                                               2.1301                                                                             -0.7044                                                                            2.6529                                                                             0.0166                                                                             0.0259                                   1.8532                                                                             0.2340                                                                             2.6502                                                                             0.0112                                                                             0.0268                                                                               4.2762                                                                             0.2028                                                                             2.6259                                                                             0.0287                                                                             0.0256                                   2.3658                                                                             0.4556                                                                             2.6503                                                                             0.0138                                                                             0.0268                                                                               4.3573                                                                             -0.7058                                                                            2.6623                                                                             0.0235                                                                             0.0241                                   -0.0765                                                                            0.5799                                                                             2.6412                                                                             0.0098                                                                             0.0276                                                                               3.2484                                                                             -0.6068                                                                            2.6604                                                                             0.0263                                                                             0.0256                                   0.6068                                                                             1.9138                                                                             2.6670                                                                             0.0159                                                                             0.0272                                                                               2.3150                                                                             0.3838                                                                             2.6359                                                                             0.0189                                                                             0.0256                                   0.7795                                                                             3.0143                                                                             2.6633                                                                             0.0085                                                                             0.0268                                                                               2.4674                                                                             0.0767                                                                             2.6533                                                                             0.0100                                                                             0.0262                                   2.6302                                                                             0.5857                                                                             2.6441                                                                             0.0132                                                                             0.0268                                                                               3.6872                                                                             -0.3802                                                                            2.6633                                                                             -0.0017                                                                            0.0270                                   2.3896                                                                             -0.1482                                                                            2.6484                                                                             0.0136                                                                             0.0259                                                                               4.2593                                                                             0.3231                                                                             2.6709                                                                             0.0046                                                                             0.0280                                   0.9996                                                                             0.8614                                                                             2.6424                                                                             0.0143                                                                             0.0269                                                                               2.3995                                                                             1.0908                                                                             2.6628                                                                             0.0104                                                                             0.0273                                   0.3206                                                                             1.7205                                                                             2.6221                                                                             0.0283                                                                             0.0283                                                                               1.0033                                                                             0.0602                                                                             2.6500                                                                             0.0035                                                                             0.0263                                   -0.9574                                                                            1.5233                                                                             2.6500                                                                             0.0266                                                                             0.0290                                                                               0.9218                                                                             1.9083                                                                             2.6392                                                                             0.0146                                                                             0.0275                                   0.3145                                                                             1.0702                                                                             2.6471                                                                             0.0271                                                                             0.0278                                                                               -1.4739                                                                            0.8555                                                                             2.6547                                                                             0.0068                                                                             0.0266                                   0.9822                                                                             0.0562                                                                             2.6508                                                                             0.0245                                                                             0.0287                                                                               4.1403                                                                             -0.5153                                                                            2.6518                                                                             0.0097                                                                             0.0265                                   1.0848                                                                             0.8120                                                                             2.6585                                                                             0.0344                                                                             0.0304                                                                               2.3858                                                                             0.3037                                                                             2.6584                                                                             -0.0047                                                                            0.0262                                   2.5617                                                                             0.9379                                                                             2.6477                                                                             0.0240                                                                             0.0288                                                                               3.3598                                                                             3.9377                                                                             2.6676                                                                             0.0058                                                                             0.0266                                   1.8837                                                                             -0.3464                                                                            2.6472                                                                             0.0170                                                                             0.0299                                                                               1.4439                                                                             1.4509                                                                             2.6513                                                                             0.0050                                                                             0.0266                                   2.8369                                                                             0.1251                                                                             2.6482                                                                             0.0144                                                                             0.0284                                                                               1.3224                                                                             0.3870                                                                             2.6727                                                                             -0.0039                                                                            0.0269                                   2.4522                                                                             0.9358                                                                             2.6453                                                                             0.0235                                                                             0.0280                                                                               2.5823                                                                             1.9315                                                                             2.6450                                                                             0.0079                                                                             0.0279                                   1.9589                                                                             -1.3417                                                                            2.6415                                                                             0.0240                                                                             0.0277                                                                               3.2087                                                                             0.7643                                                                             2.6466                                                                             0.0055                                                                             0.0272                                   1.3455                                                                             0.6804                                                                             2.6231                                                                             0.0233                                                                             0.0279                                                                               2.8025                                                                             -0.0533                                                                            2.6661                                                                             0.0052                                                                             0.0274                                   2.5731                                                                             0.6440                                                                             2.6563                                                                             0.0205                                                                             0.0284                                                                               3.4046                                                                             -0.5692                                                                            2.6662                                                                             0.0054                                                                             0.0260                                   2.3715                                                                             1.0267                                                                             2.6350                                                                             0.0190                                                                             0.0265                                                                               1.9658                                                                             -0.2587                                                                            2.6588                                                                             0.0142                                                                             0.0267                                   0.8248                                                                             0.0342                                                                             2.6443                                                                             0.0188                                                                             0.0255                                                                               0.9427                                                                             0.0930                                                                             2.6652                                                                             0.0080                                                                             0.0274                                   4.0151                                                                             1.4206                                                                             2.6550                                                                             0.0107                                                                             0.0253                                                                               2.8967                                                                             -0.6680                                                                            2.6548                                                                             0.0182                                                                             0.0274                                   2.3502                                                                             0.9319                                                                             2.6543                                                                             0.0155                                                                             0.0267                                                                               5.4560                                                                             0.3104                                                                             2.6515                                                                             0.0132                                                                             0.0266                                   2.7333                                                                             0.7978                                                                             2.6222                                                                             0.0166                                                                             0.0272                                                                               3.7057                                                                             -0.8309                                                                            2.6644                                                                             0.0078                                                                             0.0269                                   2.6753                                                                             0.3975                                                                             2.6486                                                                             0.0264                                                                             0.0273                                                                               3.6215                                                                             -1.2732                                                                            2.6478                                                                             0.0118                                                                             0.0266                                   1.9267                                                                             -0.2385                                                                            2.6543                                                                             0.0234                                                                             0.0272                                                                               2.8189                                                                             0.3384                                                                             2.6340                                                                             0.0238                                                                             0.0268                                   1.1337                                                                             0.5564                                                                             2.6713                                                                             0.0188                                                                             0.0277                                                                               3.2183                                                                             1.2530                                                                             2.6493                                                                             0.0178                                                                             0.0269                                   2.7561                                                                             -0.5895                                                                            0.6696                                                                             0.0150                                                                             0.0268                                                                               2.5761                                                                             0.7542                                                                             2.6567                                                                             0.0173                                                                             0.0266                                   2.7175                                                                             -0.6888                                                                            2.6656                                                                             0.0085                                                                             0.0278                                                                               4.0201                                                                             1.2854                                                                             2.6544                                                                             0.0083                                                                             0.0256                                   2.4440                                                                             0.5642                                                                             2.6626                                                                             0.0045                                                                             0.0282                                                                               3.8720                                                                             0.1014                                                                             2.6478                                                                             0.0094                                                                             0.0263                                   2.8028                                                                             -0.2576                                                                            2.6617                                                                             0.0184                                                                             0.0289                                                                               3.0358                                                                             0.1117                                                                             2.6610                                                                             0.0040                                                                             0.0276                                   6.3446                                                                             0.3900                                                                             2.6728                                                                             0.0234                                                                             0.0286                                                                               2.7408                                                                             0.1807                                                                             2.6403                                                                             0.0144                                                                             0.0275                                   2.4150                                                                             -0.0385                                                                            2.6543                                                                             0.0274                                                                             0.0278                                                                               2.7843                                                                             0.2746                                                                             2.6397                                                                             0.0152                                                                             0.0295                                   1.9136                                                                             0.1868                                                                             2.6491                                                                             0.0179                                                                             0.0277                                                                               4.4952                                                                             -0.8797                                                                            2.6676                                                                             0.0180                                                                             0.0295                                   0.0907                                                                             1.2002                                                                             2.6507                                                                             0.0147                                                                             0.0273                                                                               1.6285                                                                             0.3092                                                                             2.6492                                                                             0.0146                                                                             0.0299                                   3.4023                                                                             -0.1532                                                                            2.6522                                                                             0.0213                                                                             0.0262                                                                               1.5632                                                                             0.3186                                                                             2.6561                                                                             0.0135                                                                             0.0281                                   4.5587                                                                             -0.3275                                                                            2.6518                                                                             0.0169                                                                             0.0273                                                                               3.2917                                                                             0.1881                                                                             2.6698                                                                             0.0162                                                                             0.0294                                   6.0413                                                                             -0.3415                                                                            2.6657                                                                             0.0234                                                                             0.0271                                                                               5.2697                                                                             0.1221                                                                             2.6352                                                                             0.0161                                                                             0.0284                                   6.2663                                                                             -0.6160                                                                            2.6260                                                                             0.0194                                                                             0.0275                                                                               2.5333                                                                             -1.2059                                                                            2.6512                                                                             0.0189                                                                             0.0284                                   5.2508                                                                             1.0085                                                                             2.6420                                                                             0.0176                                                                             0.0278                                                                               1.6533                                                                             0.7955                                                                             2.6393                                                                             0.0242                                                                             0.0264                                   4.6750                                                                             -0.2285                                                                            2.6368                                                                             0.0050                                                                             0.0278                                                                               1.6166                                                                             -0.5779                                                                            2.6373                                                                             0.0194                                                                             0.0266                                   3.4859                                                                             0.3573                                                                             2.6514                                                                             0.0089                                                                             0.0273                                                                               2.4632                                                                             0.1684                                                                             2.6402                                                                             0.0137                                                                             0.0282                                   3.2865                                                                             -0.4428                                                                            2.6438                                                                             0.0110                                                                             0.0272                                                                               2.0405                                                                             0.2591                                                                             2.6443                                                                             0.0082                                                                             0.0288                                   0.9737                                                                             0.2788                                                                             2.6436                                                                             0.0119                                                                             0.0266                                                                               1.6062                                                                             -0.1324                                                                            2.6497                                                                             0.0129                                                                             0.0277                                   1.8191                                                                             -0.3396                                                                            2.6394                                                                             0.0176                                                                             0.0269                                                                               1.4704                                                                             0.8413                                                                             2.6411                                                                             0.0071                                                                             0.0273                                   1.8988                                                                             -0.7615                                                                            2.6696                                                                             0.0140                                                                             0.0262                                                                               1.1826                                                                             0.0579                                                                             2.6412                                                                             0.0115                                                                             0.0272                                   4.0011                                                                             -0.3604                                                                            2.6313                                                                             0.0140                                                                             0.0269                                                                               1.5670                                                                             0.0932                                                                             2.6570                                                                             0.0071                                                                             0.0277                                   6.7076                                                                             0.4947                                                                             2.6647                                                                             0.0001                                                                             0.0266                                                                               0.3312                                                                             0.6677                                                                             2.6432                                                                             0.0047                                                                             0.0267                                   3.8433                                                                             -0.4412                                                                            2.6527                                                                             -0.0038                                                                            0.0267                                                                               1.5154                                                                             0.4973                                                                             2.6377                                                                             0.0112                                                                             0.0269                                   1.6209                                                                             1.3167                                                                             2.6587                                                                             -0.0049                                                                            0.0270                                                                               1.3781                                                                             0.5339                                                                             2.6637                                                                             0.0154                                                                             0.0270                                   6.4491                                                                             0.0879                                                                             2.6328                                                                             0.0109                                                                             0.0295                                                                               3.0018                                                                             0.2049                                                                             2.6403                                                                             0.0053                                                                             0.0307                                   4.1060                                                                             0.9849                                                                             2.6575                                                                             0.0114                                                                             0.0276                                                                               0.9180                                                                             0.1477                                                                             2.6433                                                                             0.0111                                                                             0.0289                                   2.1733                                                                             1.8947                                                                             2.6559                                                                             0.0090                                                                             0.0265                                                                               5.1066                                                                             -0.3883                                                                            2.6571                                                                             0.0036                                                                             0.0292                                   3.9780                                                                             1.3259                                                                             2.6587                                                                             0.0045                                                                             0.0253                                                                               2.6395                                                                             0.1034                                                                             2.6476                                                                             0.0008                                                                             0.0291                                   1.5406                                                                             0.9525                                                                             2.6446                                                                             0.0129                                                                             0.0263                                                                               0.6622                                                                             0.3279                                                                             2.6516                                                                             0.0083                                                                             0.0281                                   2.1788                                                                             0.4048                                                                             2.6615                                                                             0.0236                                                                             0.0261                                                                               -0.1468                                                                            1.1264                                                                             2.6465                                                                             0.0151                                                                             0.0275                                   1.9404                                                                             0.0099                                                                             2.6283                                                                             0.0130                                                                             0.0271                                                                               -0.0247                                                                            0.6362                                                                             2.6432                                                                             0.0015                                                                             0.0278                                   1.9549                                                                             0.4762                                                                             2.6221                                                                             0.0232                                                                             0.0295                                                                               1.7889                                                                             0.5632                                                                             2.6547                                                                             0.0071                                                                             0.0268                                   2.9398                                                                             0.9708                                                                             2.6359                                                                             0.0173                                                                             0.0277                                                                               0.5866                                                                             0.7823                                                                             2.6288                                                                             0.0108                                                                             0.0260                                   4.6992                                                                             0.8857                                                                             2.6581                                                                             0.0099                                                                             0.0276                                                                               0.9661                                                                             0.2051                                                                             2.6480                                                                             0.0177                                                                             0.0263                                   3.8413                                                                             1.2933                                                                             2.6491                                                                             0.0182                                                                             0.0279                                                                               4.8918                                                                             -0.3495                                                                            2.6747                                                                             0.0099                                                                             0.0267                                   0.6524                                                                             0.5740                                                                             2.6492                                                                             0.0294                                                                             0.0280                                                                               -1.0871                                                                            0.4289                                                                             2.6558                                                                             0.0135                                                                             0.0268                                   1.6230                                                                             -0.5131                                                                            2.6233                                                                             0.0344                                                                             0.0285                                                                               -0.3821                                                                            0.8696                                                                             2.6542                                                                             0.0153                                                                             0.0279                                   2.9979                                                                             0.6722                                                                             2.6589                                                                             0.0268                                                                             0.0295                                                                               1.6874                                                                             0.1765                                                                             2.6550                                                                             0.0132                                                                             0.0263                                   1.9096                                                                             -0.2110                                                                            2.6488                                                                             0.0175                                                                             0.0291                                                                               -2.1858                                                                            0.7562                                                                             2.6636                                                                             0.0080                                                                             0.0277                                   2.2477                                                                             -0.0590                                                                            2.6504                                                                             0.0276                                                                             0.0288                                                                               -2.6296                                                                            1.8506                                                                             2.6530                                                                             0.0141                                                                             0.0275                                   2.3825                                                                             -0.5209                                                                            2.6227                                                                             0.0185                                                                             0.0273                                                                               3.7543                                                                             -0.5411                                                                            2.6457                                                                             0.0121                                                                             0.0272                                   5.4062                                                                             0.6180                                                                             2.6520                                                                             0.0206                                                                             0.0294                                                                               3.5189                                                                             0.2600                                                                             2.6576                                                                             0.0053                                                                             0.0285                                   3.2851                                                                             -1.2934                                                                            2.6382                                                                             0.0243                                                                             0.0301                                                                               4.2585                                                                             0.3335                                                                             2.6607                                                                             0.0087                                                                             0.0284                                   4.5516                                                                             -1.0107                                                                            2.6595                                                                             0.0112                                                                             0.0291                                                                               6.4991                                                                             -0.4479                                                                            2.6693                                                                             -0.0018                                                                            0.0286                                   5.8935                                                                             0.0545                                                                             2.6474                                                                             0.0139                                                                             0.0287                                                                               3.1058                                                                             -0.3772                                                                            2.6617                                                                             0.0055                                                                             0.0280                                   2.5191                                                                             -0.9520                                                                            2.6533                                                                             0.0164                                                                             0.0296                                                                               4.8242                                                                             -0.9876                                                                            2.6703                                                                             0.0025                                                                             0.0290                                   5.1104                                                                             -0.4867                                                                            2.6471                                                                             0.0170                                                                             0.0282                                                                               5.9644                                                                             -0.1147                                                                            2.6495                                                                             0.0045                                                                             0.0305                                   2.1961                                                                             -0.4469                                                                            2.6241                                                                             0.0229                                                                             0.0297                                                                               1.0601                                                                             0.5997                                                                             2.6455                                                                             0.0084                                                                             0.0302                                   2.9077                                                                             0.0325                                                                             2.6495                                                                             0.0267                                                                             0.0280                                                                               3.4894                                                                             0.5805                                                                             2.6678                                                                             0.0032                                                                             0.0305                                   1.4894                                                                             -0.0662                                                                            2.6326                                                                             0.0250                                                                             0.0289                                                                               -1.6138                                                                            0.4367                                                                             2.6486                                                                             0.0101                                                                             0.0293                                   0.6220                                                                             0.7207                                                                             2.6556                                                                             0.0095                                                                             0.0291                                                                               -0.5115                                                                            1.2861                                                                             2.6422                                                                             0.0079                                                                             0.0287                                   2.5373                                                                             -0.5680                                                                            2.6398                                                                             0.0147                                                                             0.0285                                                                               0.7145                                                                             1.4908                                                                             2.6305                                                                             0.0072                                                                             0.0300                                   6.0188                                                                             0.0886                                                                             2.6532                                                                             0.0095                                                                             0.0280                                                                               3.9725                                                                             1.2765                                                                             2.6562                                                                             0.0091                                                                             0.0293                                   7.2506                                                                             -0.2126                                                                            2.6417                                                                             0.0194                                                                             0.0279                                                                               5.4249                                                                             -0.0816                                                                            2.6611                                                                             0.0114                                                                             0.0296                                   4.5667                                                                             1.7860                                                                             2.6374                                                                             0.0161                                                                             0.0290                                                                               3.2026                                                                             -0.5673                                                                            2.6429                                                                             0.0200                                                                             0.0286                                   3.0172                                                                             0.1696                                                                             2.6497                                                                             0.0176                                                                             0.0274                                                                               2.0455                                                                             1.2745                                                                             2.6466                                                                             0.0145                                                                             0.0286                                   3.9111                                                                             1.1394                                                                             2.6477                                                                             0.0201                                                                             0.0293                                                                               2.4188                                                                             0.9620                                                                             2.6737                                                                             -0.0002                                                                            0.0273                                   5.2551                                                                             1.5293                                                                             2.6447                                                                             0.0054                                                                             0.0295                                                                               3.3449                                                                             -0.1141                                                                            2.6555                                                                             0.0067                                                                             0.0259                                   2.1325                                                                             0.4410                                                                             2.6588                                                                             -0.0024                                                                            0.0287                                                                               4.3214                                                                             -0.0793                                                                            2.6440                                                                             0.0160                                                                             0.0270                                   2.8354                                                                             1.5409                                                                             2.6727                                                                             -0.0064                                                                            0.0288                                                                               2.7713                                                                             -0.7040                                                                            2.6426                                                                             0.0079                                                                             0.0267                                   4.5979                                                                             0.6276                                                                             2.6510                                                                             -0.0062                                                                            0.0282                                                                               0.9444                                                                             0.4459                                                                             2.6674                                                                             0.0153                                                                             0.0273                                   3.7213                                                                             -0.1407                                                                            2.6586                                                                             -0.0040                                                                            0.0274                                                                               -0.0702                                                                            0.1260                                                                             2.6674                                                                             0.0110                                                                             0.0272                                   3.6221                                                                             -0.4802                                                                            2.6571                                                                             -0.0002                                                                            0.0279                                                                               0.9428                                                                             -0.1744                                                                            2.6575                                                                             0.0133                                                                             0.0277                                   5.3641                                                                             -0.9105                                                                            2.6667                                                                             0.0057                                                                             0.0286                                                                               -0.1427                                                                            0.6357                                                                             2.6534                                                                             0.0190                                                                             0.0275                                   3.2189                                                                             -0.1153                                                                            2.6427                                                                             0.0096                                                                             0.0299                                                                               0.8759                                                                             -0.8342                                                                            2.6414                                                                             0.0150                                                                             0.0261                                   4.2735                                                                             -0.7222                                                                            2.6465                                                                             0.0117                                                                             0.0285                                                                               1.9744                                                                             0.5733                                                                             2.6486                                                                             0.0108                                                                             0.0254                                   1.9177                                                                             -0.5780                                                                            2.6568                                                                             0.0184                                                                             0.0288                                                                               -0.3617                                                                            0.0682                                                                             2.6633                                                                             0.0020                                                                             0.0264                                   3.7664                                                                             -0.5552                                                                            2.6418                                                                             0.0250                                                                             0.0282                                                                               1.7066                                                                             0.6479                                                                             2.6413                                                                             0.0091                                                                             0.0255                                   4.4524                                                                             -0.6917                                                                            2.6546                                                                             0.0171                                                                             0.0270                                                                               1.1759                                                                             0.7844                                                                             2.6420                                                                             0.0204                                                                             0.0257                                   4.4813                                                                             -0.5660                                                                            2.6697                                                                             0.0097                                                                             0.0275                                                                               2.4663                                                                             -0.4456                                                                            0.6230                                                                             0.0119                                                                             0.0267                                   4.0185                                                                             -0.5080                                                                            2.6584                                                                             0.0148                                                                             0.0268                                                                               3.7861                                                                             0.8542                                                                             2.6466                                                                             0.0061                                                                             0.0281                                   2.9151                                                                             -0.6604                                                                            2.6482                                                                             0.0165                                                                             0.0280                                                                               4.5801                                                                             -0.3225                                                                            2.6306                                                                             0.0053                                                                             0.0283                                   3.5152                                                                             1.8551                                                                             2.6349                                                                             0.0132                                                                             0.0282                                                                               0.6237                                                                             0.0838                                                                             2.6622                                                                             0.0098                                                                             0.0262                                   5.3728                                                                             0.2079                                                                             2.6492                                                                             0.0161                                                                             0.0280                                                                               2.3230                                                                             -0.1853                                                                            2.6611                                                                             0.0057                                                                             0.0269                                   4.1296                                                                             0.7023                                                                             2.6557                                                                             0.0236                                                                             0.0274                                                                               -0.1523                                                                            0.5918                                                                             2.6486                                                                             0.0133                                                                             0.0271                                   1.5990                                                                             1.2981                                                                             2.6521                                                                             0.0247                                                                             0.0288                                                                               0.9998                                                                             -0.3891                                                                            2.6457                                                                             0.0100                                                                             0.0260                                   0.4781                                                                             0.4151                                                                             2.6531                                                                             0.0249                                                                             0.0280                                                                               3.8535                                                                             -0.2113                                                                            2.6435                                                                             0.0158                                                                             0.0269                                   3.4751                                                                             1.5312                                                                             2.6590                                                                             0.0158                                                                             0.0281                                                                               2.4046                                                                             0.2231                                                                             2.6675                                                                             0.0095                                                                             0.0268                                   2.9099                                                                             1.9314                                                                             2.6745                                                                             0.0117                                                                             0.0283                                                                               3.4737                                                                             -0.0573                                                                            2.6551                                                                             0.0146                                                                             0.0252                                   2.8016                                                                             0.1320                                                                             2.6374                                                                             0.0238                                                                             0.0271                                                                               1.5853                                                                             0.6534                                                                             2.6447                                                                             0.0088                                                                             0.0269                                   4.6220                                                                             0.1202                                                                             2.6498                                                                             0.0119                                                                             0.0265                                                                               1.0597                                                                             0.6710                                                                             2.6534                                                                             0.0108                                                                             0.0282                                   2.9798                                                                             -0.4553                                                                            2.6474                                                                             0.0079                                                                             0.0273                                                                               3.2592                                                                             0.8020                                                                             2.6667                                                                             0.0158                                                                             0.0284                                   1.8883                                                                             0.1973                                                                             2.6459                                                                             0.0100                                                                             0.0274                                                                               3.4381                                                                             -0.7192                                                                            2.6499                                                                             0.0178                                                                             0.0276                                   2.8240                                                                             0.9165                                                                             2.6527                                                                             0.0111                                                                             0.0272                                                                               1.0524                                                                             1.1456                                                                             2.6410                                                                             0.0279                                                                             0.0281                                   3.3219                                                                             0.3573                                                                             2.6707                                                                             0.0126                                                                             0.0270                                                                               3.1439                                                                             1.3877                                                                             2.6401                                                                             0.0210                                                                             0.0284                                   1.5746                                                                             -0.2252                                                                            2.6516                                                                             0.0158                                                                             0.0267                                                                               2.6103                                                                             0.5433                                                                             2.6599                                                                             0.0178                                                                             0.0280                                   -0.1013                                                                            -0.2693                                                                            2.6331                                                                             0.0082                                                                             0.0256                                                                               0.7634                                                                             -0.2882                                                                            2.6524                                                                             0.0155                                                                             0.0285                                   1.2971                                                                             0.6400                                                                             2.6450                                                                             0.0100                                                                             0.0260                                                                               5.7338                                                                             0.1642                                                                             2.6432                                                                             0.0120                                                                             0.0280                                   0.3191                                                                             1.3843                                                                             2.6353                                                                             0.0114                                                                             0.0291                                                                               1.2806                                                                             -1.4453                                                                            2.6367                                                                             0.0135                                                                             0.0305                                   1.6723                                                                             0.6906                                                                             2.6447                                                                             0.0094                                                                             0.0292                                                                               3.9127                                                                             0.3174                                                                             2.6348                                                                             0.0205                                                                             0.0296                                   -1.0777                                                                            -0.4901                                                                            2.6449                                                                             0.0107                                                                             0.0303                                                                               4.8539                                                                             0.4825                                                                             2.6556                                                                             0.0244                                                                             0.0282                                   -3.9291                                                                            0.5887                                                                             2.6684                                                                             0.0102                                                                             0.0285                                                                               3.8951                                                                             -0.6716                                                                            2.6331                                                                             0.0290                                                                             0.0275                                   3.1698                                                                             -0.0033                                                                            2.6637                                                                             0.0055                                                                             0.0278                                                                               3.7949                                                                             -0.5472                                                                            2.6350                                                                             0.0226                                                                             0.0264                                   4.1814                                                                             0.4482                                                                             2.6610                                                                             0.0068                                                                             0.0294                                                                               4.1283                                                                             -0.1432                                                                            2.6522                                                                             0.0194                                                                             0.0256                                   0.7354                                                                             0.5277                                                                             2.6647                                                                             0.0005                                                                             0.0278                                                                               2.7782                                                                             0.8330                                                                             2.6547                                                                             0.0195                                                                             0.0259                                   1.5022                                                                             0.5845                                                                             2.6555                                                                             0.0049                                                                             0.0291                                                                               2.7961                                                                             1.5846                                                                             2.6524                                                                             0.0105                                                                             0.0268                                   0.1747                                                                             0.8303                                                                             2.6671                                                                             0.0039                                                                             0.0289                                                                               4.1492                                                                             0.4320                                                                             2.6569                                                                             0.0070                                                                             0.0288                                   1.7663                                                                             -0.3543                                                                            2.6516                                                                             0.0137                                                                             0.0279                                                                               1.5853                                                                             -0.0143                                                                            2.6438                                                                             0.0054                                                                             0.0267                                   3.2598                                                                             0.3567                                                                             2.6312                                                                             0.0161                                                                             0.0293                                                                               3.5404                                                                             0.0249                                                                             2.6390                                                                             0.0030                                                                             0.0270                                   3.8279                                                                             0.0411                                                                             2.6401                                                                             0.0109                                                                             0.0289                                                                               2.1008                                                                             0.1933                                                                             2.6417                                                                             0.0149                                                                             0.0297                                   2.1005                                                                             -0.0471                                                                            2.6496                                                                             0.0076                                                                             0.0288                                                                               3.5209                                                                             0.2009                                                                             2.6532                                                                             0.0136                                                                             0.0299                                   1.9924                                                                             0.5669                                                                             2.6461                                                                             0.0105                                                                             0.0290                                                                               2.1517                                                                             0.3993                                                                             2.6496                                                                             0.0111                                                                             0.0289                                   0.1109                                                                             -0.3341                                                                            2.6477                                                                             0.0110                                                                             0.0286                                                                               2.8376                                                                             0.6066                                                                             2.6439                                                                             0.0089                                                                             0.0280                                   0.4289                                                                             0.1274                                                                             2.6616                                                                             0.0162                                                                             0.0301                                                                               4.9278                                                                             1.0406                                                                             2.6629                                                                             0.0037                                                                             0.0276                                   2.4044                                                                             -0.0547                                                                            2.6493                                                                             0.0069                                                                             0.0294                                                                               1.0414                                                                             0.3193                                                                             2.6315                                                                             0.0115                                                                             0.0267                                   2.5409                                                                             -0.4540                                                                            2.6388                                                                             0.0124                                                                             0.0292                                                                               2.5122                                                                             -0.2957                                                                            2.6324                                                                             0.0094                                                                             0.0271                                   2.8323                                                                             0.0917                                                                             2.6474                                                                             0.0045                                                                             0.0282                                                                               2.5141                                                                             0.5100                                                                             2.6474                                                                             -0.0031                                                                            0.0275                                   4.2888                                                                             -1.0347                                                                            2.6476                                                                             0.0110                                                                             0.0287                                                                               3.3576                                                                             0.3773                                                                             2.6411                                                                             0.0029                                                                             0.0298                                   6.1028                                                                             0.0240                                                                             2.6362                                                                             0.0075                                                                             0.0283                                                                               4.9494                                                                             0.4993                                                                             2.6557                                                                             0.0024                                                                             0.0299                                   3.8667                                                                             0.0410                                                                             2.6496                                                                             0.0064                                                                             0.0288                                                                               1.8925                                                                             -0.1692                                                                            2.6501                                                                             0.0116                                                                             0.0298                                   3.0977                                                                             0.7536                                                                             2.6560                                                                             0.0003                                                                             0.0280                                                                               2.7189                                                                             0.4081                                                                             2.6547                                                                             0.0134                                                                             0.0306                                   3.8780                                                                             0.4261                                                                             2.6433                                                                             0.0109                                                                             0.0270                                                                               1.4020                                                                             -0.2088                                                                            2.6489                                                                             0.0119                                                                             0.0304                                   2.9133                                                                             -0.5165                                                                            2.6393                                                                             0.0000                                                                             0.0297                                                                               -0.0538                                                                            -0.1441                                                                            2.6435                                                                             0.0110                                                                             0.0312                                   -0.0911                                                                            -0.1187                                                                            2.6506                                                                             0.0027                                                                             0.0300                                                                               -0.8963                                                                            0.5918                                                                             2.6530                                                                             0.0208                                                                             0.0299                                   0.6107                                                                             0.9822                                                                             2.6700                                                                             0.0097                                                                             0.0283                                                                               2.5659                                                                             0.5307                                                                             2.6420                                                                             0.0162                                                                             0.0300                                   2.6790                                                                             1.2073                                                                             2.6627                                                                             0.0067                                                                             0.0272                                                                               1.8333                                                                             0.8272                                                                             2.6608                                                                             0.0041                                                                             0.0282                                   -0.1156                                                                            1.3299                                                                             2.6482                                                                             0.0057                                                                             0.0263                                                                               2.7699                                                                             0.9731                                                                             2.6597                                                                             -0.0030                                                                            0.0281                                   1.6220                                                                             0.3204                                                                             2.6622                                                                             -0.0071                                                                            0.0272                                                                               2.2818                                                                             0.0372                                                                             2.6415                                                                             0.0074                                                                             0.0277                                   0.2752                                                                             1.0149                                                                             2.6339                                                                             -0.0074                                                                            0.0283                                                                               1.8543                                                                             0.7124                                                                             2.6398                                                                             0.0095                                                                             0.0267                                   3.2701                                                                             0.2997                                                                             2.6651                                                                             -0.0185                                                                            0.0290                                                                               1.5228                                                                             -0.0338                                                                            2.6310                                                                             0.0225                                                                             0.0270                                   1.6401                                                                             0.8781                                                                             2.6409                                                                             -0.0063                                                                            0.0278                                                                               2.6691                                                                             -0.3775                                                                            2.6517                                                                             0.0216                                                                             0.0266                                   1.1425                                                                             1.2459                                                                             2.6266                                                                             0.0060                                                                             0.0284                                                                               3.4645                                                                             -0.2822                                                                            2.6460                                                                             0.0244                                                                             0.0266                                   1.0338                                                                             1.4907                                                                             2.6520                                                                             0.0130                                                                             0.0274                                                                               4.4304                                                                             0.3474                                                                             2.6474                                                                             0.0225                                                                             0.0267                                   1.4116                                                                             1.7192                                                                             2.6528                                                                             0.0084                                                                             0.0263                                                                               2.2574                                                                             1.2972                                                                             2.6428                                                                             0.0175                                                                             0.0295                                   1.2370                                                                             1.2381                                                                             2.6368                                                                             0.0110                                                                             0.0259                                                                               2.1549                                                                             -0.2944                                                                            2.6601                                                                             0.0214                                                                             0.0302                                   3.1371                                                                             0.3696                                                                             2.6395                                                                             0.0041                                                                             0.0264                                                                               3.6838                                                                             -0.3037                                                                            2.6772                                                                             0.0154                                                                             0.0287                                   3.6616                                                                             0.5363                                                                             2.6498                                                                             0.0127                                                                             0.0253                                                                               1.9460                                                                             0.6013                                                                             2.6773                                                                             0.0118                                                                             0.0295                                   3.2428                                                                             0.0226                                                                             2.6381                                                                             0.0131                                                                             0.0249                                                                               1.5834                                                                             0.4680                                                                             2.6543                                                                             0.0063                                                                             0.0299                                   1.4966                                                                             0.8059                                                                             2.6598                                                                             0.0071                                                                             0.0267                                                                               2.4040                                                                             -0.1473                                                                            2.6630                                                                             0.0042                                                                             0.0309                                   3.3710                                                                             0.1274                                                                             2.6446                                                                             0.0031                                                                             0.0259                                                                               2.4609                                                                             -0.0096                                                                            2.6593                                                                             0.0013                                                                             0.0314                                   2.2512                                                                             1.2683                                                                             2.6330                                                                             0.0058                                                                             0.0263                                                                               1.2939                                                                             0.5399                                                                             2.6563                                                                             -0.0020                                                                            0.0291                                   2.0922                                                                             -1.2040                                                                            2.6365                                                                             0.0015                                                                             0.0257                                                                               0.2950                                                                             1.3836                                                                             2.6611                                                                             0.0085                                                                             0.0294                                   0.5129                                                                             1.2030                                                                             2.6625                                                                             0.0057                                                                             0.0283                                                                               0.4828                                                                             -0.4701                                                                            2.6594                                                                             0.0100                                                                             0.0281                                   0.6839                                                                             0.2860                                                                             2.6772                                                                             0.0000                                                                             0.0282                                                                               -0.9117                                                                            0.7955                                                                             2.6495                                                                             0.0074                                                                             0.0298                                   3.8595                                                                             0.7487                                                                             2.6423                                                                             0.0029                                                                             0.0275                                                                               2.6197                                                                             0.2072                                                                             2.6263                                                                             0.0141                                                                             0.0283                                   1.3922                                                                             -1.0101                                                                            2.6687                                                                             0.0025                                                                             0.0275                                                                               2.3680                                                                             0.5693                                                                             2.6519                                                                             0.0225                                                                             0.0274                                   0.5921                                                                             -0.2253                                                                            2.6437                                                                             0.0025                                                                             0.0280                                                                               5.2723                                                                             -0.1830                                                                            2.6533                                                                             0.0122                                                                             0.0285                                   2.6396                                                                             -0.6700                                                                            2.6697                                                                             0.0092                                                                             0.0271                                                                               2.7228                                                                             0.4345                                                                             2.6373                                                                             0.0168                                                                             0.0302                                   2.6209                                                                             0.3472                                                                             2.6489                                                                             0.0137                                                                             0.0283                                                                               3.7672                                                                             2.6780                                                                             2.6494                                                                             0.0154                                                                             0.0310                                   4.6424                                                                             -0.5596                                                                            2.6508                                                                             0.0112                                                                             0.0295                                                                               0.8358                                                                             1.5049                                                                             2.6537                                                                             0.0134                                                                             0.0304                                   2.8564                                                                             -0.9806                                                                            2.6726                                                                             0.0081                                                                             0.0277                                                                               2.8557                                                                             0.4694                                                                             2.6581                                                                             0.0111                                                                             0.0300                                   1.9871                                                                             0.2777                                                                             2.6572                                                                             0.0115                                                                             0.0291                                                                               3.3125                                                                             0.7627                                                                             2.6312                                                                             0.0081                                                                             0.0287                                   2.4162                                                                             0.0060                                                                             2.6575                                                                             0.0054                                                                             0.0275                                                                               2.1653                                                                             0.3396                                                                             2.6251                                                                             0.0145                                                                             0.0271                                   1.7996                                                                             0.2835                                                                             2.6738                                                                             0.0091                                                                             0.0267                                                                               4.0440                                                                             -0.1704                                                                            2.6486                                                                             0.0093                                                                             0.0282                                   3.6385                                                                             -0.6738                                                                            2.6611                                                                             0.0084                                                                             0.0282                                                                               3.1525                                                                             1.7506                                                                             2.6495                                                                             0.0062                                                                             0.0296                                   4.7833                                                                             0.1569                                                                             2.6577                                                                             0.0125                                                                             0.0285                                                                               2.6372                                                                             0.8261                                                                             2.6321                                                                             0.0137                                                                             0.0273                                   2.4901                                                                             0.3596                                                                             2.6558                                                                             0.0067                                                                             0.0279                                                                               3.8692                                                                             0.3528                                                                             2.6401                                                                             0.0107                                                                             0.0264                                   2.2168                                                                             0.2011                                                                             2.6372                                                                             0.0164                                                                             0.0287                                                                               0.4961                                                                             0.2141                                                                             2.6398                                                                             0.0145                                                                             0.0271                                   4.4380                                                                             -0.5967                                                                            2.6624                                                                             0.0048                                                                             0.0306                                                                               -2.0289                                                                            0.5504                                                                             2.6653                                                                             0.0086                                                                             0.0282                                   3.3658                                                                             -1.0464                                                                            2.6435                                                                             0.0038                                                                             0.0311                                                                               0.3985                                                                             1.6094                                                                             2.6754                                                                             0.0117                                                                             0.0283                                   3.0643                                                                             -0.4288                                                                            2.6456                                                                             0.0061                                                                             0.0309                                                                               2.7526                                                                             2.2494                                                                             2.6572                                                                             0.0092                                                                             0.0274                                   3.5938                                                                             0.5403                                                                             2.6347                                                                             0.0002                                                                             0.0304                                                                               0.8530                                                                             2.9245                                                                             2.6513                                                                             0.0096                                                                             0.0278                                   2.4859                                                                             -0.4920                                                                            2.6633                                                                             0.0165                                                                             0.0274                                                                               1.6767                                                                             1.9616                                                                             2.6511                                                                             0.0235                                                                             0.0248                                   1.5234                                                                             -0.4379                                                                            2.6661                                                                             0.0258                                                                             0.0277                                                                               1.3075                                                                             2.2255                                                                             2.6732                                                                             0.0202                                                                             0.0241                                   3.8672                                                                             -0.0981                                                                            2.6523                                                                             0.0206                                                                             0.0273                                                                               2.0693                                                                             1.8574                                                                             2.6412                                                                             0.0187                                                                             0.0253                                   4.0436                                                                             0.5305                                                                             2.6686                                                                             0.0218                                                                             0.0296                                                                               1.0395                                                                             2.0545                                                                             2.6487                                                                             0.0156                                                                             0.0249                                   0.9796                                                                             0.8253                                                                             2.6591                                                                             0.0049                                                                             0.0297                                                                               2.4440                                                                             0.3822                                                                             2.6512                                                                             0.0160                                                                             0.0253                                   -0.5808                                                                            1.1265                                                                             2.6465                                                                             0.0034                                                                             0.0286                                                                               2.0225                                                                             0.3172                                                                             2.6528                                                                             0.0088                                                                             0.0260                                   1.5748                                                                             0.8738                                                                             2.6514                                                                             0.0039                                                                             0.0278                                                                               1.9715                                                                             0.0421                                                                             2.6360                                                                             0.0161                                                                             0.0255                                   4.0370                                                                             -0.7495                                                                            2.6529                                                                             0.0086                                                                             0.0271                                                                               2.5746                                                                             -0.0536                                                                            2.6686                                                                             0.0071                                                                             0.0258                                   -0.6101                                                                            0.2988                                                                             0.6368                                                                             0.0047                                                                             0.0255                                                                               -0.6930                                                                            0.9567                                                                             2.6559                                                                             -0.0057                                                                            0.0262                                   2.8700                                                                             -0.1349                                                                            2.6603                                                                             0.0085                                                                             0.0256                                                                               1.4628                                                                             -0.3478                                                                            2.6501                                                                             0.0076                                                                             0.0270                                   -0.4733                                                                            -0.0489                                                                            2.6587                                                                             0.0102                                                                             0.0261                                                                               1.0105                                                                             -0.0304                                                                            2.6684                                                                             0.0161                                                                             0.0269                                   0.7370                                                                             0.9188                                                                             2.6538                                                                             0.0092                                                                             0.0254                                                                               -3.2263                                                                            1.7481                                                                             2.6436                                                                             0.0063                                                                             0.0268                                   2.9300                                                                             0.3353                                                                             2.6462                                                                             0.0123                                                                             0.0256                                                                               1.9017                                                                             0.7542                                                                             2.6517                                                                             0.0098                                                                             0.0286                                   2.0886                                                                             1.3236                                                                             2.6357                                                                             0.0084                                                                             0.0265                                                                               4.0304                                                                             0.1766                                                                             2.6383                                                                             0.0132                                                                             0.0287                                   2.1879                                                                             -0.7745                                                                            2.6446                                                                             0.0131                                                                             0.0277                                                                               2.4128                                                                             0.1159                                                                             2.6529                                                                             0.0164                                                                             0.0288                                   4.1685                                                                             -0.6752                                                                            2.6428                                                                             0.0037                                                                             0.0277                                                                               0.0305                                                                             -0.0196                                                                            2.6599                                                                             0.0181                                                                             0.0280                                   2.0810                                                                             -0.3573                                                                            2.6473                                                                             0.0101                                                                             0.0285                                                                               3.2232                                                                             -0.9333                                                                            2.6418                                                                             0.0167                                                                             0.0290                                   -0.6869                                                                            -0.0661                                                                            2.6559                                                                             0.0097                                                                             0.0279                                                                               1.1432                                                                             0.1834                                                                             2.6454                                                                             0.0072                                                                             0.0281                                   0.7397                                                                             -0.4398                                                                            2.6338                                                                             0.0154                                                                             0.0260                                                                               2.2215                                                                             -0.1014                                                                            2.6425                                                                             0.0104                                                                             0.0289                                   3.6310                                                                             0.1990                                                                             2.6586                                                                             0.0114                                                                             0.0263                                                                               -0.2825                                                                            0.1978                                                                             2.6392                                                                             0.0148                                                                             0.0279                                   1.9068                                                                             -0.2643                                                                            2.6450                                                                             0.0150                                                                             0.0274                                                                               3.0083                                                                             1.2311                                                                             2.6516                                                                             0.0137                                                                             0.0277                                   2.2251                                                                             -0.8130                                                                            2.6657                                                                             0.0225                                                                             0.0288                                                                               4.3219                                                                             1.9201                                                                             2.6487                                                                             0.0107                                                                             0.0282                                   4.5440                                                                             -0.7951                                                                            2.6656                                                                             0.0236                                                                             0.0290                                                                               3.1885                                                                             0.4025                                                                             2.6428                                                                             0.0144                                                                             0.0285                                   3.6395                                                                             0.0707                                                                             2.6593                                                                             0.0215                                                                             0.0283                                                                               2.2906                                                                             0.6217                                                                             2.6499                                                                             0.0147                                                                             0.0275                                   3.1062                                                                             -0.1092                                                                            2.6534                                                                             0.0256                                                                             0.0291                                                                               1.6757                                                                             2.2050                                                                             2.6363                                                                             0.0159                                                                             0.0274                                   5.8110                                                                             1.1381                                                                             2.6480                                                                             0.0235                                                                             0.0274                                                                               0.8952                                                                             1.4798                                                                             2.6554                                                                             0.0043                                                                             0.0286                                   4.6908                                                                             -0.5021                                                                            2.6532                                                                             0.0198                                                                             0.0278                                                                               2.5448                                                                             -0.2973                                                                            2.6300                                                                             0.0210                                                                             0.0285                                   3.3988                                                                             -1.0302                                                                            2.6438                                                                             0.0205                                                                             0.0277                                                                               -0.2174                                                                            0.0775                                                                             2.6680                                                                             0.0275                                                                             0.0286                                   2.1869                                                                             -0.3422                                                                            2.6431                                                                             0.0193                                                                             0.0267                                                                               0.2083                                                                             0.4909                                                                             2.6408                                                                             0.0320                                                                             0.0293                                   2.4650                                                                             -0.0120                                                                            2.6280                                                                             0.0228                                                                             0.0268                                                                               2.8221                                                                             1.2709                                                                             2.6459                                                                             0.0317                                                                             0.0282                                   1.9170                                                                             1.0726                                                                             2.6483                                                                             0.0201                                                                             0.0252                                                                               2.6995                                                                             2.1093                                                                             2.6641                                                                             0.0205                                                                             0.0283                                   2.7506                                                                             1.1504                                                                             2.6275                                                                             0.0244                                                                             0.0257                                                                               2.6368                                                                             0.7217                                                                             2.6688                                                                             0.0101                                                                             0.0282                                   3.0049                                                                             0.6225                                                                             2.6525                                                                             0.0141                                                                             0.0270                                                                               -1.3189                                                                            0.0573                                                                             2.6343                                                                             0.0140                                                                             0.0282                                   0.5434                                                                             2.3585                                                                             2.6478                                                                             0.0048                                                                             0.0266                                                                               -0.6446                                                                            1.7212                                                                             2.6509                                                                             0.0045                                                                             0.0285                                   1.9139                                                                             0.1617                                                                             2.6423                                                                             0.0004                                                                             0.0282                                                                               -3.4074                                                                            1.2886                                                                             2.6476                                                                             0.0058                                                                             0.0267                                   0.8947                                                                             0.6350                                                                             2.6599                                                                             0.0047                                                                             0.0282                                                                               -1.1605                                                                            1.1116                                                                             2.6598                                                                             -0.0004                                                                            0.0285                                   2.5632                                                                             0.4094                                                                             2.6625                                                                             0.0022                                                                             0.0278                                                                               2.0567                                                                             0.8284                                                                             2.6497                                                                             0.0098                                                                             0.0284                                   2.5362                                                                             0.6529                                                                             2.6759                                                                             0.0108                                                                             0.0275                                                                               4.7300                                                                             -0.4794                                                                            2.6370                                                                             0.0110                                                                             0.0280                                   1.7303                                                                             -0.0473                                                                            2.6527                                                                             0.0157                                                                             0.0280                                                                               2.2970                                                                             -0.0991                                                                            2.6521                                                                             0.0149                                                                             0.0270                                   1.9303                                                                             -0.0363                                                                            2.6395                                                                             0.0177                                                                             0.0286                                                                               3.4457                                                                             -1.0124                                                                            2.6544                                                                             0.0210                                                                             0.0275                                   1.0476                                                                             -1.1605                                                                            2.6387                                                                             0.0152                                                                             0.0283                                                                               1.5088                                                                             -0.6728                                                                            2.6432                                                                             0.0082                                                                             0.0280                                   1.2120                                                                             1.0038                                                                             2.6646                                                                             0.0138                                                                             0.0278                                                                               1.6876                                                                             -0.9120                                                                            2.6438                                                                             0.0075                                                                             0.0279                                   -0.9859                                                                            0.7097                                                                             2.6552                                                                             0.0107                                                                             0.0298                                                                               2.5889                                                                             0.0662                                                                             2.6504                                                                             0.0088                                                                             0.0276                                   2.0854                                                                             0.7761                                                                             2.6404                                                                             0.0101                                                                             0.0288                                                                               1.5850                                                                             0.2148                                                                             2.6511                                                                             0.0166                                                                             0.0278                                   -0.6495                                                                            1.2349                                                                             2.6366                                                                             0.0089                                                                             0.0290                                                                               0.0334                                                                             0.3286                                                                             2.6512                                                                             0.0046                                                                             0.0278                                   0.9019                                                                             -0.0660                                                                            2.6482                                                                             0.0116                                                                             0.0297                                                                               1.2341                                                                             1.4716                                                                             2.6544                                                                             0.0102                                                                             0.0269                                   5.1570                                                                             -0.0790                                                                            2.6551                                                                             0.0093                                                                             0.0288                                                                               2.5901                                                                             0.6790                                                                             2.6403                                                                             0.0153                                                                             0.0273                                   2.6019                                                                             0.5844                                                                             2.6532                                                                             0.0087                                                                             0.0284                                                                               4.1424                                                                             0.7296                                                                             2.6512                                                                             0.0194                                                                             0.0274                                   1.3537                                                                             0.3319                                                                             2.6628                                                                             0.0120                                                                             0.0285                                                                               1.0951                                                                             0.6219                                                                             2.6605                                                                             0.0161                                                                             0.0281                                   0.0301                                                                             1.6327                                                                             2.6433                                                                             -0.0022                                                                            0.0265                                                                               0.4229                                                                             0.8707                                                                             2.6476                                                                             0.0097                                                                             0.0275                                   4.4572                                                                             2.8726                                                                             2.6463                                                                             0.0059                                                                             0.0268                                                                               0.5342                                                                             0.8659                                                                             2.6426                                                                             0.0043                                                                             0.0279                                   1.6601                                                                             1.2821                                                                             2.6494                                                                             -0.0022                                                                            0.0274                                                                               2.4644                                                                             0.9262                                                                             2.6485                                                                             -0.0003                                                                            0.0278                                   -0.6070                                                                            0.2824                                                                             2.6562                                                                             -0.0051                                                                            0.0283                                                                               2.3716                                                                             0.8363                                                                             2.6817                                                                             0.0010                                                                             0.0279                                   0.9233                                                                             0.0054                                                                             2.6434                                                                             0.0125                                                                             0.0285                                                                               0.5293                                                                             -0.4723                                                                            2.6486                                                                             0.0047                                                                             0.0276                                   1.6990                                                                             -0.2754                                                                            2.6555                                                                             0.0106                                                                             0.0288                                                                               1.1403                                                                             -0.3955                                                                            2.6565                                                                             0.0061                                                                             0.0272                                   0.9473                                                                             1.1233                                                                             2.6369                                                                             0.0090                                                                             0.0291                                                                               0.2209                                                                             0.9781                                                                             2.6658                                                                             0.0093                                                                             0.0275                                   2.1586                                                                             1.1393                                                                             2.6536                                                                             0.0108                                                                             0.0280                                                                               2.1736                                                                             -0.0985                                                                            2.6635                                                                             0.0026                                                                             0.0277                                   3.3017                                                                             0.4679                                                                             2.6401                                                                             0.0130                                                                             0.0272                                                                               2.6073                                                                             -0.2020                                                                            2.6497                                                                             0.0048                                                                             0.0298                                   3.3170                                                                             1.2340                                                                             2.6372                                                                             0.0037                                                                             0.0281                                                                               2.0440                                                                             0.0734                                                                             2.6529                                                                             0.0082                                                                             0.0283                                   5.1318                                                                             1.0244                                                                             2.6369                                                                             -0.0050                                                                            0.0279                                                                               1.3921                                                                             -0.9175                                                                            2.6449                                                                             0.0092                                                                             0.0283                                   -2.1840                                                                            0.1555                                                                             2.6394                                                                             0.0076                                                                             0.0284                                                                               2.8801                                                                             -0.0183                                                                            2.6668                                                                             0.0141                                                                             0.0289                                   1.4641                                                                             0.1219                                                                             2.6534                                                                             0.0210                                                                             0.0298                                                                               1.8914                                                                             -0.3138                                                                            2.6502                                                                             0.0149                                                                             0.0288                                   1.8987                                                                             -0.2571                                                                            2.6623                                                                             0.0104                                                                             0.0305                                                                               1.5328                                                                             0.0073                                                                             2.6422                                                                             0.0159                                                                             0.0292                                   1.2267                                                                             0.3674                                                                             2.6374                                                                             0.0098                                                                             0.0301                                                                               2.2038                                                                             0.6103                                                                             2.6415                                                                             0.0166                                                                             0.0275                                   4.5438                                                                             -0.5718                                                                            2.6563                                                                             0.0079                                                                             0.0274                                                                               0.1819                                                                             0.1265                                                                             2.6442                                                                             0.0122                                                                             0.0266                                   3.9378                                                                             -0.0941                                                                            2.6522                                                                             0.0116                                                                             0.0289                                                                               2.5810                                                                             0.4495                                                                             2.6455                                                                             0.0159                                                                             0.0264                                   3.8107                                                                             0.4374                                                                             2.6447                                                                             0.0133                                                                             0.0265                                                                               4.9803                                                                             0.1533                                                                             2.6577                                                                             0.0088                                                                             0.0281                                   0.9219                                                                             1.0296                                                                             2.6593                                                                             0.0023                                                                             0.0267                                                                               1.9600                                                                             -0.1685                                                                            2.6546                                                                             0.0094                                                                             0.0271                                   -0.7946                                                                            -0.1208                                                                            2.6684                                                                             0.0183                                                                             0.0259                                                                               4.3646                                                                             0.4360                                                                             2.6572                                                                             0.0151                                                                             0.0277                                   0.6349                                                                             0.7902                                                                             2.6466                                                                             0.0139                                                                             0.0262                                                                               5.2818                                                                             -0.4535                                                                            2.6343                                                                             0.0140                                                                             0.0278                                   0.2548                                                                             0.6140                                                                             2.6594                                                                             0.0152                                                                             0.0254                                                                               5.3174                                                                             -0.1191                                                                            2.6347                                                                             0.0096                                                                             0.0276                                   1.5266                                                                             -0.0736                                                                            2.6209                                                                             0.0200                                                                             0.0259                                                                               3.3036                                                                             -0.1611                                                                            2.6650                                                                             0.0040                                                                             0.0275                                   0.9587                                                                             0.5604                                                                             2.6546                                                                             0.0160                                                                             0.0261                                                                               1.5648                                                                             -0.0127                                                                            2.6613                                                                             0.0024                                                                             0.0260                                   0.5502                                                                             -0.0683                                                                            2.6519                                                                             0.0193                                                                             0.0280                                                                               3.0502                                                                             -0.0797                                                                            2.6643                                                                             0.0045                                                                             0.0257                                   -0.0524                                                                            0.4337                                                                             2.6446                                                                             0.0241                                                                             0.0282                                                                               0.0012                                                                             0.2290                                                                             2.6425                                                                             0.0105                                                                             0.0273                                   3.4571                                                                             0.6155                                                                             2.6454                                                                             0.0165                                                                             0.0276                                                                               0.4493                                                                             1.1653                                                                             2.6542                                                                             0.0065                                                                             0.0273                                   3.5822                                                                             1.0265                                                                             2.6705                                                                             0.0213                                                                             0.0272                                                                               2.3258                                                                             -0.0671                                                                            2.6437                                                                             0.0065                                                                             0.0268                                   -0.1879                                                                            -0.5071                                                                            2.6524                                                                             0.0124                                                                             0.0261                                                                               -0.6535                                                                            0.3324                                                                             2.6467                                                                             0.0069                                                                             0.0262                                   4.1596                                                                             0.4234                                                                             2.6602                                                                             0.0104                                                                             0.0265                                                                               1.6022                                                                             0.4215                                                                             2.6606                                                                             0.0018                                                                             0.0258                                   3.9447                                                                             0.5440                                                                             2.6517                                                                             0.0107                                                                             0.0276                                                                               5.4338                                                                             -0.3640                                                                            2.6601                                                                             -0.0052                                                                            0.0262                                   5.9727                                                                             0.0270                                                                             2.6431                                                                             0.0096                                                                             0.0281                                                                               3.0069                                                                             -0.0380                                                                            2.6609                                                                             -0.0004                                                                            0.0257                                   3.9769                                                                             -0.6364                                                                            2.6692                                                                             0.0100                                                                             0.0267                                                                               4.6487                                                                             -0.7413                                                                            2.6461                                                                             -0.0082                                                                            0.0261                                   2.5700                                                                             -0.1099                                                                            2.6669                                                                             0.0071                                                                             0.0265                                                                               2.3456                                                                             1.4983                                                                             2.6747                                                                             -0.0128                                                                            0.0261                                   2.6408                                                                             -0.0658                                                                            2.6480                                                                             0.0047                                                                             0.0262                                                                               0.9232                                                                             0.6104                                                                             2.6761                                                                             -0.0015                                                                            0.0260                                   5.1297                                                                             -0.2224                                                                            2.6402                                                                             0.0108                                                                             0.0277                                                                               3.6712                                                                             -0.5355                                                                            2.6573                                                                             0.0134                                                                             0.0260                                   4.4384                                                                             -0.3064                                                                            2.6710                                                                             0.0086                                                                             0.0269                                                                               3.0536                                                                             0.0784                                                                             2.6518                                                                             0.0162                                                                             0.0256                                   0.6683                                                                             0.0891                                                                             2.6660                                                                             0.0067                                                                             0.0280                                                                               2.0485                                                                             -0.0320                                                                            2.6570                                                                             0.0210                                                                             0.0260                                   1.1178                                                                             0.5595                                                                             2.6713                                                                             0.0025                                                                             0.0271                                                                               0.7658                                                                             0.6243                                                                             2.6659                                                                             0.0206                                                                             0.0278                                   2.8530                                                                             0.1346                                                                             2.6392                                                                             0.0125                                                                             0.0268                                                                               2.1972                                                                             0.3205                                                                             2.6600                                                                             0.0195                                                                             0.0286                                   2.3643                                                                             0.9962                                                                             2.6663                                                                             0.0102                                                                             0.0268                                                                               4.3132                                                                             0.2104                                                                             2.6628                                                                             0.0035                                                                             0.0281                                   2.9706                                                                             1.0720                                                                             2.6506                                                                             0.0107                                                                             0.0262                                                                               3.7862                                                                             0.8854                                                                             2.6579                                                                             0.0044                                                                             0.0257                                   2.3584                                                                             1.3715                                                                             2.6710                                                                             0.0062                                                                             0.0265                                                                               0.8642                                                                             -0.1307                                                                            2.6658                                                                             0.0130                                                                             0.0260                                   3.0730                                                                             0.2261                                                                             2.6625                                                                             -0.0055                                                                            0.0271                                                                               2.4608                                                                             -0.3940                                                                            2.6529                                                                             0.0223                                                                             0.0253                                   2.8465                                                                             0.9877                                                                             2.6729                                                                             0.0027                                                                             0.0268                                                                               4.7740                                                                             -1.0357                                                                            2.6358                                                                             0.0272                                                                             0.0260                                   4.5659                                                                             0.9317                                                                             2.6660                                                                             0.0101                                                                             0.0269                                                                               2.2991                                                                             -0.3983                                                                            2.6635                                                                             0.0187                                                                             0.0262                                   3.2618                                                                             0.3351                                                                             2.6549                                                                             0.0026                                                                             0.0284                                                                               -1.0895                                                                            0.5343                                                                             2.6718                                                                             0.0236                                                                             0.0265                                   0.2888                                                                             0.4908                                                                             2.6363                                                                             0.0037                                                                             0.0286                                                                               -3.2780                                                                            0.8399                                                                             2.6332                                                                             0.0272                                                                             0.0249                                   3.9037                                                                             -0.0052                                                                            2.6558                                                                             0.0094                                                                             0.0283                                                                               1.5092                                                                             -0.2351                                                                            2.6305                                                                             0.0232                                                                             0.0247                                   6.3764                                                                             -0.0523                                                                            2.6490                                                                             0.0207                                                                             0.0286                                                                               3.6238                                                                             -0.0202                                                                            2.6333                                                                             0.0269                                                                             0.0253                                   3.8420                                                                             0.7315                                                                             2.6564                                                                             0.0173                                                                             0.0274                                                                               -0.6864                                                                            -0.7927                                                                            2.6653                                                                             0.0190                                                                             0.0244                                   3.5595                                                                             1.0538                                                                             2.6607                                                                             0.0018                                                                             0.0260                                                                               2.3271                                                                             0.5117                                                                             2.6576                                                                             0.0111                                                                             0.0268                                   1.4890                                                                             1.5426                                                                             2.6444                                                                             0.0038                                                                             0.0281                                                                               3.4678                                                                             -0.5160                                                                            2.6312                                                                             0.0219                                                                             0.0271                                   1.6431                                                                             1.5211                                                                             2.6623                                                                             0.0003                                                                             0.0280                                                                               4.0844                                                                             0.3381                                                                             2.6414                                                                             0.0235                                                                             0.0272                                   7.0789                                                                             1.5869                                                                             2.6375                                                                             0.0109                                                                             0.0280                                                                               1.7332                                                                             1.4703                                                                             2.6545                                                                             0.0288                                                                             0.0274                                   0.4056                                                                             1.1337                                                                             2.6308                                                                             -0.0004                                                                            0.0281                                                                               1.5435                                                                             0.2032                                                                             2.6426                                                                             0.0270                                                                             0.0284                                   1.9508                                                                             0.1685                                                                             2.6672                                                                             -0.0080                                                                            0.0283                                                                               3.6030                                                                             0.1524                                                                             2.6446                                                                             0.0250                                                                             0.0288                                   3.5263                                                                             0.7111                                                                             2.6749                                                                             -0.0015                                                                            0.0298                                                                               2.3926                                                                             1.0664                                                                             2.6427                                                                             0.0253                                                                             0.0271                                   2.9074                                                                             0.8124                                                                             2.6472                                                                             0.0074                                                                             0.0296                                                                               3.1148                                                                             0.8710                                                                             2.6512                                                                             0.0206                                                                             0.0288                                   4.3008                                                                             1.1020                                                                             2.6594                                                                             0.0050                                                                             0.0303                                                                               5.5580                                                                             2.5570                                                                             2.6410                                                                             0.0170                                                                             0.0290                                   4.5186                                                                             3.1189                                                                             2.6580                                                                             0.0053                                                                             0.0301                                                                               6.5631                                                                             1.3390                                                                             2.6522                                                                             0.0251                                                                             0.0279                                   4.4749                                                                             0.9265                                                                             2.6566                                                                             0.0101                                                                             0.0285                                                                               4.9646                                                                             0.7019                                                                             2.6284                                                                             0.0204                                                                             0.0259                                   3.9182                                                                             0.3658                                                                             2.6546                                                                             0.0183                                                                             0.0267                                                                               2.8412                                                                             0.1108                                                                             2.6576                                                                             0.0219                                                                             0.0262                                   1.9300                                                                             0.0746                                                                             2.6647                                                                             0.0062                                                                             0.0265                                                                               2.0493                                                                             0.7615                                                                             2.6695                                                                             0.0191                                                                             0.0286                                   0.2646                                                                             -0.0234                                                                            2.6416                                                                             0.0095                                                                             0.0263                                                                               1.0309                                                                             -0.2066                                                                            2.6537                                                                             0.0152                                                                             0.0287                                   -0.4509                                                                            0.1115                                                                             2.6648                                                                             0.0076                                                                             0.0270                                                                               1.8359                                                                             -0.4614                                                                            2.6623                                                                             0.0172                                                                             0.0274                                   -0.1518                                                                            0.3614                                                                             2.6626                                                                             0.0069                                                                             0.0270                                                                               2.7884                                                                             1.0948                                                                             2.6535                                                                             0.0106                                                                             0.0274                                   0.6836                                                                             0.4393                                                                             2.6526                                                                             0.0102                                                                             0.0265                                                                               3.1118                                                                             -1.2587                                                                            2.6532                                                                             0.0106                                                                             0.0278                                   -1.7740                                                                            0.1456                                                                             2.6445                                                                             0.0045                                                                             0.0268                                                                               4.5918                                                                             -0.6839                                                                            2.6432                                                                             0.0137                                                                             0.0275                                   -3.6034                                                                            1.1210                                                                             2.6592                                                                             0.0065                                                                             0.0283                                                                               0.5702                                                                             -0.2243                                                                            2.6595                                                                             0.0052                                                                             0.0261                                   0.3268                                                                             1.3207                                                                             2.6515                                                                             0.0038                                                                             0.0266                                                                               1.8162                                                                             0.8339                                                                             2.6661                                                                             0.0017                                                                             0.0264                                   3.5586                                                                             1.0948                                                                             2.6293                                                                             0.0035                                                                             0.0265                                                                               3.7247                                                                             1.3633                                                                             2.6557                                                                             0.0142                                                                             0.0277                                   4.4315                                                                             1.1170                                                                             2.6597                                                                             0.0019                                                                             0.0260                                                                               1.0224                                                                             -0.0986                                                                            2.6554                                                                             0.0144                                                                             0.0295                                   3.1592                                                                             1.7409                                                                             2.6691                                                                             -0.0002                                                                            0.0274                                                                               4.8915                                                                             -0.8557                                                                            2.6505                                                                             0.0091                                                                             0.0292                                   0.5839                                                                             1.3312                                                                             1.6584                                                                             0.0071                                                                             0.0279                                                                               3.8756                                                                             -0.2202                                                                            2.6538                                                                             0.0028                                                                             0.0285                                   3.6199                                                                             0.4896                                                                             2.6590                                                                             0.0105                                                                             0.0270                                                                               2.5612                                                                             1.5678                                                                             2.6451                                                                             0.0192                                                                             0.0286                                   0.9424                                                                             1.1979                                                                             2.6426                                                                             0.0083                                                                             0.0263                                                                               5.1084                                                                             1.3565                                                                             2.6446                                                                             0.0236                                                                             0.0288                                   0.5843                                                                             1.2535                                                                             2.6618                                                                             0.0160                                                                             0.0260                                                                               2.8938                                                                             1.7622                                                                             2.6685                                                                             0.0200                                                                             0.0290                                   1.9951                                                                             2.0845                                                                             2.6624                                                                             0.0143                                                                             0.0247                                                                               2.9189                                                                             1.0361                                                                             2.6562                                                                             0.0087                                                                             0.0269                                   1.2262                                                                             -0.0298                                                                            2.6513                                                                             0.0124                                                                             0.0275                                                                               0.3924                                                                             2.1663                                                                             2.6554                                                                             0.0071                                                                             0.0287                                   0.6420                                                                             -0.2706                                                                            2.6393                                                                             0.0102                                                                             0.0285                                                                               4.5414                                                                             0.8863                                                                             2.6598                                                                             0.0014                                                                             0.0275                                   -0.8042                                                                            -0.4390                                                                            2.6416                                                                             0.0064                                                                             0.0280                                                                               1.0753                                                                             -0.1298                                                                            2.6423                                                                             0.0010                                                                             0.0292                                   1.4448                                                                             0.0099                                                                             2.6592                                                                             0.0127                                                                             0.0267                                                                               0.8121                                                                             -0.5827                                                                            2.6658                                                                             0.0047                                                                             0.0296                                   1.8841                                                                             0.3502                                                                             2.6514                                                                             0.0135                                                                             0.0272                                                                               1.4015                                                                             -0.1371                                                                            2.6499                                                                             0.0160                                                                             0.0283                                   -0.2486                                                                            0.5802                                                                             2.6519                                                                             0.0035                                                                             0.0266                                                                               2.1710                                                                             0.0892                                                                             2.6521                                                                             0.0098                                                                             0.0285                                   1.1293                                                                             0.1072                                                                             2.6474                                                                             0.0032                                                                             0.0276                                                                               0.1990                                                                             0.2120                                                                             2.6614                                                                             0.0033                                                                             0.0280                                   -1.0104                                                                            0.4067                                                                             2.6515                                                                             0.0089                                                                             0.0276                                                                               2.2428                                                                             -0.1115                                                                            2.6398                                                                             0.0193                                                                             0.0271                                   2.0688                                                                             0.3041                                                                             2.6280                                                                             0.0114                                                                             0.0278                                                                               1.5548                                                                             0.3439                                                                             2.6594                                                                             0.0093                                                                             0.0255                                   2.7238                                                                             0.4195                                                                             2.6678                                                                             0.0069                                                                             0.0280                                                                               0.2581                                                                             -0.2724                                                                            2.6442                                                                             0.0102                                                                             0.0264                                   0.4229                                                                             0.3570                                                                             2.6406                                                                             0.0147                                                                             0.0266                                                                               3.2040                                                                             0.6067                                                                             2.6419                                                                             0.0085                                                                             0.0265                                   -0.9443                                                                            0.8134                                                                             2.6451                                                                             0.0087                                                                             0.0266                                                                               3.3994                                                                             -0.9342                                                                            2.6442                                                                             0.0216                                                                             0.0268                                   0.3128                                                                             2.4965                                                                             2.6588                                                                             0.0149                                                                             0.0267                                                                               3.2037                                                                             0.0887                                                                             2.6376                                                                             0.0171                                                                             0.0282                                   1.1257                                                                             1.1640                                                                             2.6530                                                                             0.0108                                                                             0.0274                                                                               3.0981                                                                             1.3866                                                                             2.6370                                                                             0.0256                                                                             0.0276                                   4.0244                                                                             1.2582                                                                             2.6627                                                                             0.0151                                                                             0.0270                                                                               1.9120                                                                             -0.1101                                                                            2.6397                                                                             0.0207                                                                             0.0279                                   1.8541                                                                             0.3421                                                                             2.6470                                                                             0.0110                                                                             0.0263                                                                               3.3069                                                                             0.5651                                                                             2.6455                                                                             0.0108                                                                             0.0288                                   0.4366                                                                             0.1956                                                                             2.6421                                                                             0.0091                                                                             0.0261                                                                               3.8852                                                                             0.2353                                                                             2.6817                                                                             0.0094                                                                             0.0268                                   1.9781                                                                             -0.6378                                                                            2.6464                                                                             0.0124                                                                             0.0256                                                                               2.2380                                                                             -0.3964                                                                            2.6630                                                                             0.0206                                                                             0.0274                                   3.8899                                                                             0.0540                                                                             2.6525                                                                             0.0134                                                                             0.0269                                                                               2.6375                                                                             0.0467                                                                             2.6463                                                                             0.0212                                                                             0.0262                                   5.1043                                                                             -0.2189                                                                            2.6408                                                                             0.0063                                                                             0.0266                                                                               2.6117                                                                             0.7350                                                                             2.6554                                                                             0.0164                                                                             0.0263                                   4.1349                                                                             -0.7842                                                                            2.6429                                                                             -0.0021                                                                            0.0274                                                                               4.7098                                                                             0.2994                                                                             2.6426                                                                             0.0261                                                                             0.0273                                   3.1778                                                                             0.0280                                                                             2.6731                                                                             -0.0007                                                                            0.0275                                                                               2.7484                                                                             0.3372                                                                             2.6469                                                                             0.0275                                                                             0.0282                                   3.0040                                                                             -0.3277                                                                            2.6527                                                                             -0.0001                                                                            0.0272                                                                               1.3111                                                                             1.4114                                                                             2.6481                                                                             0.0238                                                                             0.0289                                   2.4491                                                                             0.8047                                                                             2.6499                                                                             0.0136                                                                             0.0277                                                                               1.5063                                                                             -0.3867                                                                            2.6476                                                                             0.0200                                                                             0.0283                                   3.6734                                                                             0.8520                                                                             2.6235                                                                             0.0235                                                                             0.0261                                                                               3.4101                                                                             0.3981                                                                             2.6491                                                                             0.0224                                                                             0.0287                                   4.0732                                                                             1.0147                                                                             2.6610                                                                             0.0172                                                                             0.0280                                                                               1.9477                                                                             0.7951                                                                             2.6304                                                                             0.0214                                                                             0.0280                                   2.4566                                                                             -0.3133                                                                            2.6466                                                                             0.0150                                                                             0.0290                                                                               1.2475                                                                             0.8096                                                                             2.6447                                                                             0.0152                                                                             0.0295                                   2.3615                                                                             -1.0314                                                                            2.6431                                                                             0.0171                                                                             0.0292                                                                               1.7750                                                                             -0.4215                                                                            2.6451                                                                             0.0166                                                                             0.0288                                   2.7956                                                                             2.1782                                                                             2.6457                                                                             0.0113                                                                             0.0292                                                                               4.1949                                                                             -0.4634                                                                            2.6538                                                                             0.0107                                                                             0.0282                                   3.8857                                                                             0.5837                                                                             2.6401                                                                             0.0047                                                                             0.0270                                                                               0.9383                                                                             0.3368                                                                             2.6471                                                                             0.0040                                                                             0.0286                                   0.3098                                                                             0.1682                                                                             2.6448                                                                             0.0018                                                                             0.0280                                                                               0.1038                                                                             1.2578                                                                             2.6753                                                                             0.0036                                                                             0.0283                                   1.4268                                                                             0.7145                                                                             2.6525                                                                             0.0032                                                                             0.0279                                                                               1.4740                                                                             0.5378                                                                             2.6521                                                                             0.0078                                                                             0.0287                                   5.0809                                                                             0.8639                                                                             2.6639                                                                             0.0027                                                                             0.0284                                                                               1.8098                                                                             0.9854                                                                             2.6506                                                                             0.0049                                                                             0.0283                                   2.7999                                                                             0.7697                                                                             2.6583                                                                             0.0129                                                                             0.0275                                                                               2.5242                                                                             0.8604                                                                             2.6420                                                                             0.0160                                                                             0.0282                                   2.4657                                                                             2.3038                                                                             2.6665                                                                             0.0170                                                                             0.0279                                                                               -1.4269                                                                            0.5906                                                                             2.6524                                                                             0.0139                                                                             0.0270                                   1.3886                                                                             1.9390                                                                             2.6527                                                                             0.0117                                                                             0.0288                                                                               -0.7576                                                                            0.9428                                                                             2.6161                                                                             0.0222                                                                             0.0260                                   0.4252                                                                             1.6008                                                                             2.6731                                                                             0.0086                                                                             0.0287                                                                               2.2445                                                                             0.5815                                                                             2.6567                                                                             0.0133                                                                             0.0279                                   3.2488                                                                             -0.3095                                                                            2.6445                                                                             0.0080                                                                             0.0298                                                                               4.0496                                                                             0.3554                                                                             2.6583                                                                             0.0225                                                                             0.0283                                   3.4282                                                                             0.0413                                                                             2.6503                                                                             0.0036                                                                             0.0298                                                                               1.8331                                                                             -0.1162                                                                            2.6575                                                                             0.0105                                                                             0.0282                                   -0.1567                                                                            0.4306                                                                             2.6588                                                                             0.0028                                                                             0.0297                                                                               1.8228                                                                             0.6216                                                                             2.6499                                                                             -0.0018                                                                            0.0283                                   -0.3306                                                                            -0.1996                                                                            2.6620                                                                             0.0146                                                                             0.0298                                                                               2.4639                                                                             1.4466                                                                             2.6479                                                                             0.0057                                                                             0.0300                                   3.1718                                                                             -0.2588                                                                            2.6601                                                                             0.0075                                                                             0.0282                                                                               2.4224                                                                             0.4991                                                                             2.6380                                                                             0.0141                                                                             0.0305                                   4.5633                                                                             -0.6224                                                                            2.6515                                                                             0.0121                                                                             0.0270                                                                               0.5228                                                                             -0.2796                                                                            2.6530                                                                             0.0152                                                                             0.0295                                   2.3567                                                                             -0.2019                                                                            2.6475                                                                             0.0081                                                                             0.0279                                                                               0.3318                                                                             0.7774                                                                             2.6590                                                                             0.0143                                                                             0.0288                                   2.9599                                                                             -0.4544                                                                            2.6564                                                                             0.0159                                                                             0.0286                                                                               3.3861                                                                             -0.8487                                                                            2.6456                                                                             0.0237                                                                             0.0266                                   0.1565                                                                             -0.0316                                                                            2.6530                                                                             0.0139                                                                             0.0282                                                                               5.6870                                                                             0.9246                                                                             2.6469                                                                             0.0175                                                                             0.0264                                   1.0336                                                                             1.3844                                                                             2.6379                                                                             0.0228                                                                             0.0295                                                                               5.2257                                                                             0.7969                                                                             2.6423                                                                             0.0136                                                                             0.0267                                   3.2637                                                                             0.4233                                                                             2.6566                                                                             0.0179                                                                             0.0281                                                                               4.1179                                                                             0.8993                                                                             2.6331                                                                             0.0183                                                                             0.0276                                   4.9498                                                                             0.8442                                                                             2.6484                                                                             0.0291                                                                             0.0290                                                                               3.8998                                                                             -0.5084                                                                            2.6355                                                                             0.0171                                                                             0.0274                                   2.8847                                                                             -0.0839                                                                            2.6452                                                                             0.0121                                                                             0.0293                                                                               3.5508                                                                             -0.4697                                                                            2.6595                                                                             0.0100                                                                             0.0272                                   3.6036                                                                             0.6884                                                                             2.6542                                                                             0.0091                                                                             0.0299                                                                               1.8113                                                                             -0.0557                                                                            2.6595                                                                             0.0017                                                                             0.0263                                   3.7397                                                                             -0.4237                                                                            2.6604                                                                             0.0070                                                                             0.0303                                                                               2.7113                                                                             0.1602                                                                             2.6347                                                                             0.0082                                                                             0.0279                                   5.6072                                                                             0.1001                                                                             2.6582                                                                             0.0180                                                                             0.0291                                                                               2.4072                                                                             1.7801                                                                             2.6561                                                                             0.0114                                                                             0.0287                                   3.9784                                                                             -0.0682                                                                            2.6508                                                                             0.0125                                                                             0.0286                                                                               4.3130                                                                             0.1972                                                                             2.6514                                                                             0.0180                                                                             0.0290                                   3.6761                                                                             -0.0185                                                                            2.6524                                                                             0.0138                                                                             0.0284                                                                               2.4398                                                                             -0.2087                                                                            2.6449                                                                             0.0150                                                                             0.0290                                   2.2692                                                                             0.2765                                                                             2.6479                                                                             0.0191                                                                             0.0279                                                                               2.5890                                                                             0.5050                                                                             2.6553                                                                             0.0174                                                                             0.0286                                   0.0502                                                                             0.4871                                                                             2.6591                                                                             0.0216                                                                             0.0264                                                                               1.2731                                                                             2.1100                                                                             2.6455                                                                             0.0185                                                                             0.0288                                   0.8404                                                                             0.5158                                                                             2.6550                                                                             0.0173                                                                             0.0267                                                                               2.5884                                                                             0.8251                                                                             2.6630                                                                             0.0212                                                                             0.0287                                   2.1339                                                                             3.0670                                                                             2.6460                                                                             0.0156                                                                             0.0276                                                                               0.8515                                                                             1.2410                                                                             2.6491                                                                             0.0112                                                                             0.0278                                   0.0947                                                                             1.5087                                                                             2.6667                                                                             0.0107                                                                             0.0266                                                                               1.1706                                                                             1.4115                                                                             2.6599                                                                             0.0083                                                                             0.0285                                   1.3842                                                                             0.6537                                                                             2.6383                                                                             0.0050                                                                             0.0273                                                                               5.0791                                                                             2.2891                                                                             2.6597                                                                             0.0114                                                                             0.0293                                   -0.3840                                                                            0.8243                                                                             2.6403                                                                             0.0152                                                                             0.0269                                                                               0.6228                                                                             0.5953                                                                             2.6490                                                                             0.0100                                                                             0.0291                                   -1.6382                                                                            -0.1082                                                                            2.6569                                                                             0.0097                                                                             0.0274                                                                               0.2148                                                                             -0.8826                                                                            2.6350                                                                             0.0070                                                                             0.0287                                   0.8941                                                                             0.3400                                                                             2.6423                                                                             0.0102                                                                             0.0268                                                                               2.2044                                                                             0.4423                                                                             2.6377                                                                             0.0146                                                                             0.0283                                   2.7181                                                                             -0.0058                                                                            2.6492                                                                             0.0293                                                                             0.0252                                                                               2.5474                                                                             1.0160                                                                             2.6481                                                                             -0.0017                                                                            0.0290                                   1.0129                                                                             3.1164                                                                             2.6438                                                                             0.0253                                                                             0.0264                                                                               3.7621                                                                             1.0184                                                                             2.6504                                                                             0.0044                                                                             0.0273                                   0.9331                                                                             0.1955                                                                             2.6374                                                                             0.0204                                                                             0.0263                                                                               3.8919                                                                             -0.0224                                                                            2.6381                                                                             0.0104                                                                             0.0264                                   0.6524                                                                             0.6338                                                                             2.6304                                                                             0.0176                                                                             0.0268                                                                               -0.2702                                                                            1.2786                                                                             2.6654                                                                             0.0068                                                                             0.0279                                   2.3501                                                                             1.0547                                                                             2.6633                                                                             0.0141                                                                             0.0270                                                                               -0.1055                                                                            1.1032                                                                             2.6311                                                                             0.0127                                                                             0.0275                                   2.0990                                                                             2.0117                                                                             2.6654                                                                             0.0098                                                                             0.0264                                                                               -0.1303                                                                            0.4648                                                                             2.6320                                                                             0.0201                                                                             0.0286                                   2.7173                                                                             0.5939                                                                             2.6617                                                                             0.0123                                                                             0.0273                                                                               0.5568                                                                             -0.1941                                                                            2.6359                                                                             0.0112                                                                             0.0277                                   3.1411                                                                             -0.0283                                                                            2.6463                                                                             0.0157                                                                             0.0279                                                                               1.6020                                                                             0.7825                                                                             2.6508                                                                             0.0121                                                                             0.0294                                   3.5748                                                                             0.3333                                                                             2.6463                                                                             0.0060                                                                             0.0277                                                                               1.8143                                                                             0.5321                                                                             2.6609                                                                             0.0184                                                                             0.0307                                   1.3423                                                                             0.0623                                                                             2.6696                                                                             0.0075                                                                             0.0275                                                                               5.1196                                                                             1.7048                                                                             2.6547                                                                             0.0184                                                                             0.0302                                   2.4877                                                                             0.0307                                                                             2.6250                                                                             0.0078                                                                             0.0267                                                                               3.3711                                                                             0.3097                                                                             2.6608                                                                             0.0129                                                                             0.0300                                   2.3450                                                                             0.8141                                                                             2.6411                                                                             0.0070                                                                             0.0262                                                                               1.8721                                                                             0.6081                                                                             2.6505                                                                             0.0140                                                                             0.0289                                   1.0281                                                                             1.1227                                                                             2.6487                                                                             0.0115                                                                             0.0266                                                                               1.7909                                                                             0.7543                                                                             2.6382                                                                             0.0073                                                                             0.0281                                   1.6338                                                                             0.3851                                                                             2.6420                                                                             0.0113                                                                             0.0279                                                                               0.2996                                                                             2.0289                                                                             2.6432                                                                             0.0120                                                                             0.0268                                   2.3765                                                                             0.8552                                                                             2.6319                                                                             0.0131                                                                             0.0278                                                                               -0.4868                                                                            0.8916                                                                             2.6765                                                                             0.0089                                                                             0.0267                                   0.5997                                                                             0.2045                                                                             2.6471                                                                             0.0146                                                                             0.0279                                                                               -0.9695                                                                            1.8391                                                                             2.6457                                                                             0.0112                                                                             0.0272                                   2.3748                                                                             0.6919                                                                             2.6551                                                                             0.0134                                                                             0.0274                                                                               2.1807                                                                             1.3016                                                                             2.6471                                                                             0.0152                                                                             0.0272                                   4.1416                                                                             -0.0590                                                                            2.6578                                                                             0.0124                                                                             0.0271                                                                               4.0239                                                                             1.8312                                                                             2.6445                                                                             0.0096                                                                             0.0272                                   0.7270                                                                             -0.0817                                                                            2.6518                                                                             0.0099                                                                             0.0276                                                                               3.9373                                                                             1.1000                                                                             2.6570                                                                             0.0061                                                                             0.0284                                   0.8343                                                                             1.5377                                                                             2.6524                                                                             0.0033                                                                             0.0283                                                                               2.3175                                                                             1.5627                                                                             2.6611                                                                             0.0038                                                                             0.0276                                   0.0228                                                                             1.0780                                                                             2.6399                                                                             0.0011                                                                             0.0283                                                                               1.8356                                                                             2.0715                                                                             2.6623                                                                             0.0034                                                                             0.0269                                   0.1908                                                                             1.0884                                                                             2.6452                                                                             -0.0005                                                                            0.0285                                                                               -0.7619                                                                            0.2668                                                                             2.6391                                                                             0.0116                                                                             0.0278                                   1.7659                                                                             0.4891                                                                             2.6526                                                                             0.0062                                                                             0.0282                                                                               0.7556                                                                             0.5534                                                                             2.6620                                                                             0.0193                                                                             0.0288                                   1.9214                                                                             0.2044                                                                             2.6553                                                                             0.0063                                                                             0.0280                                                                               3.4047                                                                             0.4969                                                                             2.6287                                                                             0.0094                                                                             0.0298                                   4.2058                                                                             0.3407                                                                             2.6628                                                                             0.0036                                                                             0.0288                                                                               0.4053                                                                             1.4357                                                                             2.6665                                                                             0.0052                                                                             0.0303                                   5.2014                                                                             1.2805                                                                             2.6407                                                                             0.0106                                                                             0.0272                                                                               2.6418                                                                             -0.1232                                                                            2.6460                                                                             0.0139                                                                             0.0299                                   4.9485                                                                             2.0509                                                                             2.6474                                                                             0.0103                                                                             0.0267                                                                               2.6530                                                                             0.4778                                                                             2.6615                                                                             0.0162                                                                             0.0287                                   2.5897                                                                             0.7552                                                                             2.6476                                                                             0.0118                                                                             0.0277                                                                               2.3225                                                                             -0.6477                                                                            2.6452                                                                             0.0143                                                                             0.0290                                   2.4044                                                                             -0.3853                                                                            2.6608                                                                             0.0061                                                                             0.0281                                                                               2.5458                                                                             -0.5230                                                                            2.6639                                                                             0.0049                                                                             0.0281                                   2.3590                                                                             -0.5616                                                                            2.6515                                                                             0.0018                                                                             0.0283                                                                               2.1681                                                                             0.4676                                                                             2.6568                                                                             0.0080                                                                             0.0264                                   2.8858                                                                             -0.7616                                                                            2.6560                                                                             0.0011                                                                             0.0280                                                                               1.7262                                                                             -0.3134                                                                            2.6617                                                                             0.0123                                                                             0.0263                                   4.6098                                                                             -0.1198                                                                            2.6588                                                                             0.0077                                                                             0.0288                                                                               1.2232                                                                             0.0613                                                                             2.6690                                                                             0.0115                                                                             0.0257                                   1.6188                                                                             -0.1473                                                                            2.6554                                                                             0.0136                                                                             0.0295                                                                               1.3961                                                                             0.7318                                                                             2.6646                                                                             0.0060                                                                             0.0263                                   2.1239                                                                             -0.0802                                                                            2.6505                                                                             0.0074                                                                             0.0295                                                                               3.1541                                                                             -1.2123                                                                            2.6644                                                                             -0.0006                                                                            0.0272                                   1.9313                                                                             0.6639                                                                             2.6434                                                                             0.0209                                                                             0.0294                                                                               4.5294                                                                             -0.3398                                                                            2.6708                                                                             -0.0017                                                                            0.0282                                   0.9533                                                                             1.1370                                                                             2.6378                                                                             0.0154                                                                             0.0280                                                                               5.3214                                                                             0.3148                                                                             2.6411                                                                             0.0053                                                                             0.0286                                   1.5484                                                                             0.5190                                                                             2.6457                                                                             0.0110                                                                             0.0295                                                                               4.7477                                                                             0.3546                                                                             2.6264                                                                             0.0046                                                                             0.0290                                   5.2566                                                                             2.5180                                                                             2.6556                                                                             0.0111                                                                             0.0290                                                                               3.2063                                                                             1.7488                                                                             2.6459                                                                             0.0039                                                                             0.0306                                   0.4526                                                                             1.3544                                                                             2.6499                                                                             0.0126                                                                             0.0270                                                                               -0.1790                                                                            -0.2523                                                                            2.6463                                                                             0.0154                                                                             0.0317                                   -0.5833                                                                            1.1998                                                                             2.6595                                                                             0.0098                                                                             0.0269                                                                               1.3701                                                                             0.9826                                                                             2.6622                                                                             0.0175                                                                             0.0315                                   -1.3684                                                                            0.7704                                                                             2.6577                                                                             0.0095                                                                             0.0268                                                                               1.7797                                                                             0.5268                                                                             2.6547                                                                             0.0150                                                                             0.0303                                   1.2286                                                                             0.9597                                                                             2.6521                                                                             0.0054                                                                             0.0285                                                                               1.9769                                                                             0.8581                                                                             2.6612                                                                             0.0140                                                                             0.0299                                   1.5400                                                                             0.5103                                                                             2.6489                                                                             0.0072                                                                             0.0292                                                                               1.2695                                                                             0.2718                                                                             2.6516                                                                             0.0180                                                                             0.0297                                   -0.2355                                                                            1.8067                                                                             2.6389                                                                             0.0108                                                                             0.0305                                                                               4.6910                                                                             0.3200                                                                             2.6446                                                                             0.0156                                                                             0.0301                                   0.3408                                                                             0.8896                                                                             2.6270                                                                             0.0132                                                                             0.0292                                                                               4.3224                                                                             -0.2442                                                                            2.6515                                                                             0.0162                                                                             0.0306                                   -1.3288                                                                            0.6715                                                                             2.6637                                                                             0.0154                                                                             0.0286                                                                               4.4688                                                                             0.0786                                                                             2.6687                                                                             0.0146                                                                             0.0297                                   0.0159                                                                             0.5726                                                                             2.6496                                                                             0.0180                                                                             0.0278                                                                               -0.9428                                                                            0.1988                                                                             2.6583                                                                             0.0150                                                                             0.0283                                   1.7730                                                                             0.7545                                                                             2.6261                                                                             0.0239                                                                             0.0287                                                                               0.3166                                                                             -0.0272                                                                            2.6718                                                                             0.0076                                                                             0.0284                                   0.8351                                                                             0.3129                                                                             2.6551                                                                             0.0190                                                                             0.0293                                                                               3.1396                                                                             -0.0111                                                                            2.6564                                                                             0.0122                                                                             0.0287                                   0.6006                                                                             0.6993                                                                             2.6576                                                                             0.0094                                                                             0.0289                                                                               6.3271                                                                             1.0865                                                                             2.6439                                                                             0.0192                                                                             0.0277                                   2.0745                                                                             0.1167                                                                             2.6354                                                                             0.0012                                                                             0.0276                                                                               4.0370                                                                             1.2765                                                                             2.6696                                                                             0.0146                                                                             0.0279                                   -0.9230                                                                            0.7843                                                                             2.6515                                                                             0.0010                                                                             0.0275                                                                               3.9099                                                                             1.6605                                                                             2.6420                                                                             0.0050                                                                             0.0279                                   -0.5112                                                                            0.3836                                                                             2.6546                                                                             0.0100                                                                             0.0276                                                                               3.1395                                                                             0.9480                                                                             2.6378                                                                             0.0095                                                                             0.0281                                   3.8128                                                                             1.6595                                                                             2.6556                                                                             0.0142                                                                             0.0276                                                                               2.8466                                                                             0.1861                                                                             2.6525                                                                             0.0110                                                                             0.0280                                   2.5735                                                                             1.1601                                                                             2.6401                                                                             0.0150                                                                             0.0274                                                                               2.6217                                                                             0.2198                                                                             2.6538                                                                             0.0194                                                                             0.0277                                   2.8626                                                                             0.2179                                                                             2.6656                                                                             0.0130                                                                             0.0278                                                                               2.5850                                                                             -0.2211                                                                            2.6546                                                                             0.0168                                                                             0.0275                                   0.7093                                                                             0.9888                                                                             2.6416                                                                             -0.0015                                                                            0.0268                                                                               1.7734                                                                             -0.4521                                                                            2.6690                                                                             0.0140                                                                             0.0269                                   0.3718                                                                             -0.1843                                                                            2.6389                                                                             -0.0081                                                                            0.0278                                                                               0.1994                                                                             -0.1023                                                                            2.6459                                                                             0.0099                                                                             0.0268                                   4.0066                                                                             -0.9938                                                                            2.6538                                                                             -0.0085                                                                            0.0274                                                                               -0.2664                                                                            -0.3099                                                                            2.6482                                                                             0.0140                                                                             0.0259                                   3.1455                                                                             -0.8543                                                                            2.6478                                                                             0.0000                                                                             0.0274                                                                               2.2020                                                                             0.6222                                                                             2.6538                                                                             0.0117                                                                             0.0251                                   1.1546                                                                             1.7899                                                                             2.6351                                                                             0.0047                                                                             0.0273                                                                               3.5288                                                                             0.3787                                                                             2.6603                                                                             0.0074                                                                             0.0261                                   3.0318                                                                             1.8146                                                                             2.6625                                                                             0.0127                                                                             0.0269                                                                               4.2905                                                                             0.5942                                                                             2.6524                                                                             0.0119                                                                             0.0269                                   2.2929                                                                             0.6435                                                                             2.6342                                                                             0.0220                                                                             0.0268                                                                               5.0716                                                                             0.1238                                                                             2.6551                                                                             0.0098                                                                             0.0268                                   1.2793                                                                             0.4002                                                                             2.6510                                                                             0.0064                                                                             0.0271                                                                               3.5944                                                                             0.0487                                                                             2.6452                                                                             0.0175                                                                             0.0268                                   2.7198                                                                             -0.8388                                                                            2.6535                                                                             0.0038                                                                             0.0293                                                                               3.3508                                                                             1.1548                                                                             2.6703                                                                             0.0270                                                                             0.0259                                   3.8594                                                                             -0.7633                                                                            2.6595                                                                             0.0018                                                                             0.0302                                                                               0.4701                                                                             -0.3865                                                                            2.6434                                                                             0.0132                                                                             0.0266                                   0.4671                                                                             1.2976                                                                             2.6700                                                                             0.0058                                                                             0.0304                                                                               0.3436                                                                             0.4452                                                                             2.6521                                                                             0.0048                                                                             0.0267                                   -0.1000                                                                            0.3067                                                                             2.6306                                                                             0.0140                                                                             0.0298                                                                               0.4613                                                                             1.3513                                                                             2.6386                                                                             0.0118                                                                             0.0265                                   2.1964                                                                             -1.3313                                                                            2.6369                                                                             0.0097                                                                             0.0277                                                                               1.2653                                                                             0.8488                                                                             2.6543                                                                             0.0104                                                                             0.0270                                   1.0857                                                                             -0.0743                                                                            2.6382                                                                             0.0082                                                                             0.0277                                                                               3.3631                                                                             0.6235                                                                             2.6569                                                                             0.0186                                                                             0.0293                                   3.9880                                                                             0.2847                                                                             2.6685                                                                             0.0066                                                                             0.0275                                                                               6.1945                                                                             0.3757                                                                             2.6429                                                                             0.0159                                                                             0.0299                                   2.8966                                                                             -0.1400                                                                            2.6551                                                                             0.0176                                                                             0.0271                                                                               4.7537                                                                             -0.4098                                                                            2.6342                                                                             0.0154                                                                             0.0285                                   2.3722                                                                             -0.4042                                                                            2.6477                                                                             0.0175                                                                             0.0269                                                                               7.4002                                                                             -0.5048                                                                            2.6490                                                                             0.0148                                                                             0.0297                                   0.4406                                                                             0.0403                                                                             2.6572                                                                             0.0119                                                                             0.0268                                                                               7.6175                                                                             0.0821                                                                             2.6471                                                                             0.0107                                                                             0.0286                                   2.5005                                                                             0.1795                                                                             2.6713                                                                             0.0089                                                                             0.0287                                                                               3.4082                                                                             -0.5240                                                                            2.6322                                                                             0.0081                                                                             0.0286                                   2.5813                                                                             -0.0620                                                                            2.6429                                                                             0.0216                                                                             0.0291                                                                               3.0721                                                                             -0.9999                                                                            2.6675                                                                             0.0087                                                                             0.0280                                   2.0566                                                                             0.4226                                                                             2.6458                                                                             0.0176                                                                             0.0279                                                                               3.6894                                                                             -1.0032                                                                            2.6547                                                                             0.0243                                                                             0.0281                                   -0.4289                                                                            0.3795                                                                             2.6431                                                                             0.0192                                                                             0.0287                                                                               4.1259                                                                             -0.1939                                                                            2.6438                                                                             0.0251                                                                             0.0269                                   -0.3037                                                                            0.9158                                                                             2.6559                                                                             0.0217                                                                             0.0292                                                                               3.2361                                                                             0.4673                                                                             2.6397                                                                             0.0191                                                                             0.0267                                   3.9685                                                                             1.1807                                                                             2.6462                                                                             0.0181                                                                             0.0285                                                                               0.3932                                                                             -0.0271                                                                            2.6346                                                                             0.0302                                                                             0.0263                                   4.4875                                                                             0.4040                                                                             2.6470                                                                             0.0110                                                                             0.0286                                                                               2.7631                                                                             0.1423                                                                             2.6263                                                                             0.0200                                                                             0.0280                                   5.4220                                                                             -0.4790                                                                            2.6806                                                                             0.0051                                                                             0.0270                                                                               5.3865                                                                             -0.2185                                                                            2.6418                                                                             0.0219                                                                             0.0271                                   -0.2256                                                                            -0.0803                                                                            2.6405                                                                             0.0175                                                                             0.0273                                                                               6.3875                                                                             0.7883                                                                             2.6635                                                                             0.0162                                                                             0.0283                                   1.7033                                                                             -0.3566                                                                            2.6518                                                                             0.0124                                                                             0.0263                                                                               0.8251                                                                             -0.1095                                                                            2.6573                                                                             0.0011                                                                             0.0284                                   0.8811                                                                             -0.0025                                                                            2.6681                                                                             0.0203                                                                             0.0269                                                                               2.8821                                                                             -0.1343                                                                            2.6544                                                                             0.0076                                                                             0.0292                                   1.9472                                                                             0.5734                                                                             2.6467                                                                             0.0219                                                                             0.0258                                                                               3.7535                                                                             -0.7944                                                                            2.6549                                                                             0.0087                                                                             0.0279                                   0.6770                                                                             0.6509                                                                             2.6530                                                                             0.0181                                                                             0.0259                                                                               3.0660                                                                             -0.2597                                                                            2.6505                                                                             0.0151                                                                             0.0286                                   -1.3929                                                                            0.1215                                                                             2.6527                                                                             0.0139                                                                             0.0270                                                                               3.5204                                                                             0.8623                                                                             2.6360                                                                             0.0133                                                                             0.0294                                   0.3664                                                                             -0.2283                                                                            2.6527                                                                             0.0045                                                                             0.0263                                                                               2.6422                                                                             2.3788                                                                             2.6371                                                                             0.0258                                                                             0.0300                                   3.9267                                                                             0.1890                                                                             2.6529                                                                             0.0011                                                                             0.0259                                                                               0.9362                                                                             1.3166                                                                             2.6518                                                                             0.0221                                                                             0.0286                                   3.6658                                                                             0.1507                                                                             2.6636                                                                             0.0015                                                                             0.0258                                                                               2.0142                                                                             0.4636                                                                             2.6392                                                                             0.0151                                                                             0.0284                                   3.6656                                                                             0.4529                                                                             2.6500                                                                             0.0067                                                                             0.0269                                                                               3.8841                                                                             -0.8248                                                                            2.6407                                                                             0.0237                                                                             0.0269                                   3.9156                                                                             1.2501                                                                             2.6691                                                                             0.0054                                                                             0.0271                                                                               3.7192                                                                             -0.8515                                                                            2.6417                                                                             0.0159                                                                             0.0265                                   0.3670                                                                             1.4592                                                                             2.6570                                                                             0.0117                                                                             0.0273                                                                               1.3832                                                                             0.1959                                                                             2.6409                                                                             0.0145                                                                             0.0283                                   0.8352                                                                             0.9254                                                                             2.6459                                                                             0.0034                                                                             0.0265                                                                               -0.4132                                                                            1.0405                                                                             2.6359                                                                             0.0118                                                                             0.0270                                   0.0399                                                                             1.1958                                                                             2.6605                                                                             0.0077                                                                             0.0270                                                                               1.2472                                                                             -0.8217                                                                            2.6503                                                                             0.0162                                                                             0.0270                                   0.2184                                                                             1.1788                                                                             2.6459                                                                             0.0116                                                                             0.0279                                                                               2.1729                                                                             -0.4104                                                                            2.6391                                                                             0.0177                                                                             0.0287                                   1.5251                                                                             0.4561                                                                             2.6224                                                                             0.0180                                                                             0.0270                                                                               0.4111                                                                             -0.5810                                                                            2.6548                                                                             0.0134                                                                             0.0273                                   1.1781                                                                             2.5312                                                                             2.6479                                                                             0.0221                                                                             0.0264                                                                               -1.2347                                                                            0.2115                                                                             2.6650                                                                             0.0168                                                                             0.0266                                   -0.2543                                                                            1.7074                                                                             2.6367                                                                             0.0194                                                                             0.0262                                                                               0.8757                                                                             1.2110                                                                             2.6541                                                                             0.0157                                                                             0.0266                                   -1.0746                                                                            2.4387                                                                             2.6464                                                                             0.0130                                                                             0.0261                                                                               2.2148                                                                             0.5965                                                                             2.6675                                                                             0.0073                                                                             0.0286                                   2.1394                                                                             1.9493                                                                             2.6531                                                                             0.0069                                                                             0.0270                                                                               3.1057                                                                             -0.4192                                                                            2.6631                                                                             0.0185                                                                             0.0277                                   3.1150                                                                             1.4250                                                                             2.6579                                                                             0.0012                                                                             0.0288                                                                               4.4524                                                                             -0.3170                                                                            2.6552                                                                             0.0121                                                                             0.0276                                   3.2751                                                                             -1.1958                                                                            2.6624                                                                             0.0027                                                                             0.0294                                                                               3.4603                                                                             -0.2643                                                                            2.6422                                                                             0.0067                                                                             0.0276                                   1.4003                                                                             0.3451                                                                             2.6572                                                                             -0.0052                                                                            0.0306                                                                               4.1996                                                                             1.5294                                                                             2.6578                                                                             0.0025                                                                             0.0278                                   0.4113                                                                             0.6007                                                                             2.6564                                                                             -0.0104                                                                            0.0289                                                                               3.9469                                                                             0.4750                                                                             2.6492                                                                             0.0072                                                                             0.0281                                   3.9831                                                                             -0.0673                                                                            2.6564                                                                             -0.0046                                                                            0.0295                                                                               2.8056                                                                             0.8412                                                                             2.6631                                                                             0.0060                                                                             0.0291                                   3.3553                                                                             0.5001                                                                             2.6649                                                                             -0.0054                                                                            0.0296                                                                               0.7569                                                                             0.0451                                                                             2.6563                                                                             0.0226                                                                             0.0287                                   4.3881                                                                             0.6024                                                                             2.6452                                                                             -0.0030                                                                            0.0294                                                                               1.6724                                                                             0.5162                                                                             2.6526                                                                             0.0130                                                                             0.0287                                   5.3560                                                                             0.0170                                                                             2.6348                                                                             0.0025                                                                             0.0292                                                                               2.3075                                                                             0.4833                                                                             2.6493                                                                             0.0107                                                                             0.0281                                   4.3331                                                                             0.1299                                                                             2.6534                                                                             -0.0017                                                                            0.0290                                                                               2.1919                                                                             0.4709                                                                             2.6400                                                                             0.0136                                                                             0.0277                                   3.0023                                                                             -0.0297                                                                            2.6452                                                                             -0.0130                                                                            0.0292                                                                               1.9579                                                                             1.0331                                                                             2.6439                                                                             0.0187                                                                             0.0266                                   4.5388                                                                             1.5081                                                                             2.6604                                                                             -0.0015                                                                            0.0290                                                                               -1.3853                                                                            0.1087                                                                             2.6609                                                                             0.0146                                                                             0.0266                                   1.6685                                                                             0.6378                                                                             2.6665                                                                             0.0010                                                                             0.0281                                                                               -1.1403                                                                            0.5206                                                                             2.6548                                                                             0.0178                                                                             0.0275                                   3.6542                                                                             0.9829                                                                             2.6404                                                                             0.0136                                                                             0.0283                                                                               -0.8831                                                                            0.0882                                                                             2.6488                                                                             0.0118                                                                             0.0265                                   3.8617                                                                             1.0914                                                                             2.6691                                                                             0.0103                                                                             0.0287                                                                               0.2476                                                                             1.5763                                                                             2.6691                                                                             0.0120                                                                             0.0268                                   4.1161                                                                             0.4701                                                                             2.6483                                                                             0.0067                                                                             0.0274                                                                               1.1874                                                                             0.0094                                                                             2.6779                                                                             0.0124                                                                             0.0266                                   3.4111                                                                             0.2771                                                                             2.6678                                                                             0.0126                                                                             0.0283                                                                               0.9082                                                                             0.3569                                                                             2.6316                                                                             0.0198                                                                             0.0259                                   3.7352                                                                             0.2541                                                                             2.6485                                                                             0.0121                                                                             0.0272                                                                               0.9223                                                                             0.1321                                                                             2.6427                                                                             0.0187                                                                             0.0277                                   2.7725                                                                             -0.6144                                                                            2.6510                                                                             0.0017                                                                             0.0277                                                                               0.1546                                                                             0.1286                                                                             2.6423                                                                             0.0186                                                                             0.0263                                   2.0919                                                                             0.2541                                                                             2.6612                                                                             -0.0007                                                                            0.0282                                                                               -0.0506                                                                            0.3576                                                                             2.6472                                                                             0.0135                                                                             0.0269                                   1.4610                                                                             0.9165                                                                             2.6446                                                                             0.0084                                                                             0.0271                                                                               1.3947                                                                             0.3161                                                                             2.6536                                                                             0.0123                                                                             0.0272                                   0.5206                                                                             0.3015                                                                             2.6346                                                                             0.0040                                                                             0.0270                                                                               2.0053                                                                             0.4975                                                                             2.6200                                                                             0.0161                                                                             0.0292                                   2.7937                                                                             0.0902                                                                             2.6474                                                                             0.0069                                                                             0.0261                                                                               2.8223                                                                             -0.3436                                                                            2.6468                                                                             0.0112                                                                             0.0296                                   1.1605                                                                             0.1573                                                                             2.6523                                                                             0.0120                                                                             0.0275                                                                               1.4941                                                                             0.0100                                                                             2.6540                                                                             0.0063                                                                             0.0316                                   0.4792                                                                             0.9393                                                                             2.6766                                                                             -0.0024                                                                            0.0258                                                                               3.4509                                                                             0.1676                                                                             2.6434                                                                             0.0055                                                                             0.0295                                   1.2909                                                                             0.1712                                                                             2.6493                                                                             0.0026                                                                             0.0269                                                                               5.8147                                                                             0.8383                                                                             2.6595                                                                             0.0120                                                                             0.0291                                   0.0445                                                                             0.4291                                                                             2.6656                                                                             0.0019                                                                             0.0282                                                                               4.7016                                                                             -0.0877                                                                            2.6156                                                                             0.0091                                                                             0.0297                                   4.2947                                                                             0.0015                                                                             2.6426                                                                             0.0078                                                                             0.0269                                                                               3.4672                                                                             0.1802                                                                             2.6562                                                                             0.0030                                                                             0.0286                                   3.6570                                                                             -0.1946                                                                            2.6553                                                                             0.0022                                                                             0.0260                                                                               0.6926                                                                             1.0070                                                                             2.6504                                                                             0.0032                                                                             0.0281                                   2.0640                                                                             -1.0652                                                                            2.6667                                                                             0.0000                                                                             0.0275                                                                               -1.0279                                                                            1.6243                                                                             2.6679                                                                             -0.0009                                                                            0.0280                                   -0.7516                                                                            0.4895                                                                             2.6517                                                                             0.0082                                                                             0.0276                                                                               1.7556                                                                             1.6055                                                                             2.6504                                                                             -0.0061                                                                            0.0271                                   0.4696                                                                             1.1510                                                                             2.6595                                                                             0.0149                                                                             0.0259                                                                               2.6656                                                                             1.1491                                                                             2.6465                                                                             0.0055                                                                             0.0268                                   2.6135                                                                             0.1354                                                                             2.6603                                                                             0.0198                                                                             0.0257                                                                               1.8804                                                                             0.0489                                                                             2.6578                                                                             0.0094                                                                             0.0269                                   2.2015                                                                             0.8717                                                                             2.6764                                                                             0.0234                                                                             0.0251                                                                               1.4364                                                                             2.4511                                                                             2.6424                                                                             0.0147                                                                             0.0274                                   -1.5877                                                                            1.0282                                                                             2.6433                                                                             0.0265                                                                             0.0257                                                                               -0.8869                                                                            0.3706                                                                             2.6553                                                                             0.0233                                                                             0.0270                                   1.0911                                                                             0.9548                                                                             2.6383                                                                             0.0156                                                                             0.0273                                                                               3.8185                                                                             1.4745                                                                             2.6374                                                                             0.0212                                                                             0.0270                                   0.6405                                                                             1.0707                                                                             2.6269                                                                             0.0109                                                                             0.0263                                                                               5.2580                                                                             1.9862                                                                             2.6505                                                                             0.0093                                                                             0.0262                                   2.9855                                                                             -0.7376                                                                            2.6400                                                                             0.0163                                                                             0.0257                                                                               5.5363                                                                             2.1272                                                                             2.6450                                                                             0.0131                                                                             0.0280                                   -0.0792                                                                            1.2066                                                                             2.6596                                                                             0.0127                                                                             0.0276                                                                               3.9680                                                                             -0.8128                                                                            2.6595                                                                             0.0179                                                                             0.0283                                   1.5000                                                                             1.4515                                                                             2.6480                                                                             0.0080                                                                             0.0264                                                                               5.6487                                                                             -0.0307                                                                            2.6388                                                                             0.0154                                                                             0.0272                                   2.0032                                                                             0.7530                                                                             2.6395                                                                             0.0168                                                                             0.0278                                                                               5.0248                                                                             -0.0490                                                                            2.6583                                                                             0.0148                                                                             0.0274                                   1.9438                                                                             0.7470                                                                             0.6441                                                                             0.0142                                                                             0.0285                                                                               3.7343                                                                             0.2521                                                                             2.6457                                                                             0.0151                                                                             0.0266                                   1.7779                                                                             0.3329                                                                             2.6504                                                                             0.0194                                                                             0.0268                                                                               3.8525                                                                             -0.5475                                                                            2.6409                                                                             0.0073                                                                             0.0257                                   0.9317                                                                             0.7055                                                                             2.6594                                                                             0.0105                                                                             0.0270                                                                               1.9750                                                                             -0.3080                                                                            2.6590                                                                             0.0064                                                                             0.0262                                   1.1448                                                                             -0.2698                                                                            2.6541                                                                             0.0151                                                                             0.0282                                                                               2.4254                                                                             1.0970                                                                             2.6212                                                                             0.0087                                                                             0.0260                                   1.2180                                                                             0.6105                                                                             2.6346                                                                             0.0179                                                                             0.0277                                                                               4.1537                                                                             -0.6771                                                                            2.6481                                                                             0.0042                                                                             0.0261                                   2.7756                                                                             0.5979                                                                             2.6384                                                                             0.0193                                                                             0.0273                                                                               4.0032                                                                             -0.2603                                                                            2.6420                                                                             0.0112                                                                             0.0273                                   2.5161                                                                             1.5493                                                                             2.6370                                                                             0.0229                                                                             0.0289                                                                               1.4932                                                                             -0.1021                                                                            2.6441                                                                             0.0090                                                                             0.0269                                   2.0964                                                                             1.3332                                                                             2.6481                                                                             0.0182                                                                             0.0292                                                                               0.7664                                                                             0.8529                                                                             2.6720                                                                             0.0071                                                                             0.0257                                   3.3333                                                                             0.5501                                                                             2.6349                                                                             0.0138                                                                             0.0289                                                                               -0.4797                                                                            0.5068                                                                             2.6669                                                                             -0.0005                                                                            0.0255                                   1.7608                                                                             -0.0067                                                                            2.6443                                                                             0.0091                                                                             0.0278                                                                               0.7154                                                                             -0.3132                                                                            2.6348                                                                             0.0173                                                                             0.0257                                   3.1357                                                                             0.1307                                                                             2.6615                                                                             0.0069                                                                             0.0286                                                                               3.2984                                                                             -0.3120                                                                            2.6519                                                                             0.0163                                                                             0.0269                                   3.8387                                                                             -0.4405                                                                            2.6716                                                                             0.0088                                                                             0.0279                                                                               1.8484                                                                             0.4275                                                                             2.6477                                                                             0.0043                                                                             0.0255                                   1.3406                                                                             -0.5397                                                                            2.6671                                                                             0.0016                                                                             0.0285                                                                               4.1122                                                                             0.6229                                                                             2.6526                                                                             0.0127                                                                             0.0267                                   2.2098                                                                             0.0681                                                                             2.6647                                                                             -0.0018                                                                            0.0283                                                                               5.4264                                                                             0.5311                                                                             2.6629                                                                             0.0144                                                                             0.0270                                   3.0657                                                                             1.2731                                                                             2.6360                                                                             0.0077                                                                             0.0280                                                                               2.4485                                                                             -0.1950                                                                            2.6318                                                                             0.0194                                                                             0.0271                                   1.6042                                                                             0.4607                                                                             2.6518                                                                             0.0135                                                                             0.0275                                                                               1.6210                                                                             0.0260                                                                             2.6433                                                                             0.0204                                                                             0.0264                                   1.3719                                                                             -0.1883                                                                            2.6379                                                                             0.0151                                                                             0.0283                                                                               1.5463                                                                             0.5455                                                                             2.6639                                                                             0.0197                                                                             0.0271                                   1.7340                                                                             -0.1611                                                                            2.6531                                                                             0.0091                                                                             0.0290                                                                               -0.4220                                                                            1.5365                                                                             2.6584                                                                             0.0126                                                                             0.0266                                   3.6180                                                                             0.0326                                                                             2.6556                                                                             0.0086                                                                             0.0277                                                                               1.0062                                                                             0.8841                                                                             2.6742                                                                             0.0045                                                                             0.0269                                   2.8489                                                                             -0.6367                                                                            2.6569                                                                             0.0108                                                                             0.0263                                                                               0.0555                                                                             2.7342                                                                             2.6609                                                                             0.0119                                                                             0.0281                                   3.1276                                                                             -0.4519                                                                            2.6696                                                                             0.0063                                                                             0.0254                                                                               2.9193                                                                             0.9645                                                                             2.6589                                                                             0.0181                                                                             0.0283                                   2.6245                                                                             0.2364                                                                             2.6566                                                                             -0.0013                                                                            0.0258                                                                               0.6911                                                                             1.4240                                                                             2.6691                                                                             0.0118                                                                             0.0290                                   -0.5746                                                                            0.8892                                                                             2.6583                                                                             0.0066                                                                             0.0247                                                                               2.4935                                                                             1.7796                                                                             2.6704                                                                             0.0163                                                                             0.0289                                   0.9890                                                                             0.6048                                                                             2.6551                                                                             0.0090                                                                             0.0263                                                                               2.8286                                                                             -0.3854                                                                            2.6436                                                                             0.0077                                                                             0.0280                                   0.9238                                                                             0.9183                                                                             2.6311                                                                             0.0160                                                                             0.0258                                                                               1.7800                                                                             -0.7078                                                                            2.6339                                                                             0.0070                                                                             0.0282                                   0.7355                                                                             0.7216                                                                             2.6647                                                                             0.0058                                                                             0.0271                                                                               4.7955                                                                             0.0432                                                                             2.6554                                                                             0.0076                                                                             0.0273                                   1.4604                                                                             -0.0277                                                                            2.6728                                                                             0.0017                                                                             0.0270                                                                               4.6393                                                                             -0.1269                                                                            2.6395                                                                             0.0112                                                                             0.0280                                   2.7630                                                                             -0.8205                                                                            2.6541                                                                             0.0125                                                                             0.0274                                                                               3.5125                                                                             0.6930                                                                             2.6470                                                                             0.0095                                                                             0.0285                                   0.6435                                                                             1.0916                                                                             2.6615                                                                             0.0099                                                                             0.0277                                                                               3.3619                                                                             0.8445                                                                             2.6362                                                                             0.0111                                                                             0.0267                                   0.2236                                                                             0.5965                                                                             2.6344                                                                             0.0089                                                                             0.0279                                                                               3.1334                                                                             0.1944                                                                             2.6714                                                                             0.0139                                                                             0.0266                                   5.1111                                                                             -0.5296                                                                            2.6426                                                                             0.0100                                                                             0.0279                                                                               4.7833                                                                             -0.0917                                                                            2.6557                                                                             0.0185                                                                             0.0269                                   3.4684                                                                             -0.0110                                                                            2.6269                                                                             0.0209                                                                             0.0271                                                                               5.4401                                                                             -0.2506                                                                            2.6651                                                                             0.0073                                                                             0.0269                                   2.9153                                                                             0.4338                                                                             2.6587                                                                             0.0023                                                                             0.0274                                                                               5.4735                                                                             2.8194                                                                             2.6573                                                                             0.0185                                                                             0.0264                                   4.3987                                                                             -0.1074                                                                            2.6456                                                                             0.0091                                                                             0.0262                                                                               5.5550                                                                             1.5283                                                                             2.6546                                                                             0.0205                                                                             0.0274                                   5.6390                                                                             0.1259                                                                             2.6831                                                                             -0.0002                                                                            0.0276                                                                               2.4647                                                                             -0.4182                                                                            2.6326                                                                             0.0197                                                                             0.0264                                   4.6234                                                                             -0.3685                                                                            2.6617                                                                             0.0139                                                                             0.0270                                                                               2.5947                                                                             0.4348                                                                             2.6398                                                                             0.0166                                                                             0.0257                                   3.2167                                                                             0.4303                                                                             2.6669                                                                             0.0149                                                                             0.0269                                                                               5.2601                                                                             -0.8030                                                                            2.6339                                                                             0.0165                                                                             0.0259                                   -0.9947                                                                            1.1790                                                                             2.6456                                                                             0.0154                                                                             0.0269                                                                               1.5620                                                                             -0.3957                                                                            2.6557                                                                             0.0112                                                                             0.0267                                   0.0510                                                                             -0.6717                                                                            2.6522                                                                             0.0140                                                                             0.0279                                                                               3.1886                                                                             0.6717                                                                             2.6597                                                                             0.0152                                                                             0.0269                                   1.5499                                                                             0.7653                                                                             2.6556                                                                             0.0064                                                                             0.0275                                                                               2.3172                                                                             0.3351                                                                             2.6519                                                                             0.0128                                                                             0.0279                                   2.7515                                                                             0.2621                                                                             2.6417                                                                             0.0159                                                                             0.0276                                                                               1.7145                                                                             0.2908                                                                             2.6705                                                                             0.0150                                                                             0.0264                                   2.1329                                                                             0.3001                                                                             2.6537                                                                             0.0118                                                                             0.0287                                                                               0.4832                                                                             0.8634                                                                             2.6331                                                                             0.0134                                                                             0.0268                                   0.1038                                                                             -0.2650                                                                            2.6599                                                                             0.0121                                                                             0.0301                                                                               1.6046                                                                             0.6050                                                                             2.6525                                                                             0.0161                                                                             0.0263                                   0.5497                                                                             -0.1902                                                                            2.6464                                                                             0.0126                                                                             0.0295                                                                               1.4801                                                                             -0.4843                                                                            2.6308                                                                             0.0132                                                                             0.0272                                   4.5646                                                                             0.6390                                                                             2.6392                                                                             0.0121                                                                             0.0310                                                                               3.8580                                                                             -0.1407                                                                            2.6456                                                                             0.0123                                                                             0.0272                                   4.6423                                                                             -0.2855                                                                            2.6483                                                                             0.0051                                                                             0.0305                                                                               2.8298                                                                             -0.3796                                                                            2.6697                                                                             0.0114                                                                             0.0280                                   0.9757                                                                             0.1570                                                                             2.6571                                                                             0.0010                                                                             0.0280                                                                               4.5972                                                                             0.1429                                                                             2.6608                                                                             0.0088                                                                             0.0270                                   -0.1634                                                                            1.7612                                                                             2.6548                                                                             0.0040                                                                             0.0273                                                                               4.1364                                                                             -1.1916                                                                            2.6492                                                                             0.0112                                                                             0.0274                                   5.7496                                                                             -0.0144                                                                            2.6629                                                                             0.0036                                                                             0.0276                                                                               6.0897                                                                             -0.3205                                                                            2.6577                                                                             0.0059                                                                             0.0277                                   4.0844                                                                             2.4526                                                                             2.6451                                                                             0.0139                                                                             0.0278                                                                               4.9552                                                                             -0.4364                                                                            2.6544                                                                             0.0039                                                                             0.0267                                   1.5898                                                                             -0.4142                                                                            2.6526                                                                             0.0097                                                                             0.0297                                                                               3.1637                                                                             1.1782                                                                             2.6379                                                                             0.0215                                                                             0.0278                                   5.8530                                                                             -0.6858                                                                            2.6609                                                                             0.0158                                                                             0.0297                                                                               6.3351                                                                             0.0659                                                                             2.6617                                                                             0.0043                                                                             0.0278                                   1.4526                                                                             -0.0266                                                                            2.6490                                                                             0.0165                                                                             0.0294                                                                               3.5044                                                                             -0.1156                                                                            2.6606                                                                             0.0094                                                                             0.0281                                   4.8247                                                                             -0.4467                                                                            2.6727                                                                             0.0086                                                                             0.0285                                                                               4.9274                                                                             0.1780                                                                             2.6799                                                                             0.0167                                                                             0.0274                                   2.2071                                                                             0.7735                                                                             2.6637                                                                             0.0101                                                                             0.0280                                                                               2.8589                                                                             0.0766                                                                             2.6408                                                                             0.0165                                                                             0.0268                                   2.7602                                                                             -1.1411                                                                            2.6728                                                                             0.0041                                                                             0.0277                                                                               7.0296                                                                             1.2237                                                                             2.6407                                                                             0.0180                                                                             0.0279                                   4.7296                                                                             -0.3192                                                                            2.6857                                                                             0.0073                                                                             0.0269                                                                               6.1476                                                                             -0.6054                                                                            2.6320                                                                             0.0229                                                                             0.0284                                   3.9752                                                                             -0.0634                                                                            2.6399                                                                             0.0117                                                                             0.0286                                                                               0.0807                                                                             0.5775                                                                             2.6322                                                                             0.0250                                                                             0.0270                                   3.9231                                                                             -0.6048                                                                            2.6313                                                                             0.0151                                                                             0.0275                                                                               -0.4210                                                                            2.3943                                                                             2.6508                                                                             0.0167                                                                             0.0278                                   0.1038                                                                             1.8569                                                                             2.6337                                                                             0.0168                                                                             0.0276                                                                               0.8421                                                                             0.9277                                                                             2.6254                                                                             0.0179                                                                             0.0275                                   -0.3743                                                                            0.0590                                                                             2.6449                                                                             0.0156                                                                             0.0284                                                                               0.2053                                                                             0.7711                                                                             2.6525                                                                             0.0160                                                                             0.0275                                   1.3266                                                                             0.9062                                                                             2.6504                                                                             0.0048                                                                             0.0291                                                                               1.5198                                                                             0.1395                                                                             2.6589                                                                             0.0171                                                                             0.0280                                   0.4070                                                                             1.0268                                                                             2.6472                                                                             0.0026                                                                             0.0300                                                                               4.5912                                                                             0.1663                                                                             2.6604                                                                             0.0181                                                                             0.0266                                   5.6739                                                                             0.4286                                                                             2.6676                                                                             -0.0078                                                                            0.0288                                                                               -0.4122                                                                            0.9031                                                                             2.6257                                                                             0.0116                                                                             0.0264                                   3.1987                                                                             -0.5687                                                                            2.6523                                                                             0.0017                                                                             0.0294                                                                               0.1565                                                                             0.8077                                                                             2.6332                                                                             0.0139                                                                             0.0257                                   3.6794                                                                             0.0599                                                                             2.6551                                                                             0.0038                                                                             0.0303                                                                               3.3031                                                                             0.3603                                                                             2.6571                                                                             0.0053                                                                             0.0264                                   1.2408                                                                             -0.3776                                                                            2.6497                                                                             0.0119                                                                             0.0278                                                                               0.6351                                                                             0.1792                                                                             2.6524                                                                             0.0166                                                                             0.0270                                   -0.9869                                                                            0.4009                                                                             2.6605                                                                             0.0054                                                                             0.0288                                                                               3.6102                                                                             0.2737                                                                             2.6501                                                                             0.0126                                                                             0.0283                                   0.6435                                                                             0.2305                                                                             2.6629                                                                             0.0201                                                                             0.0309                                                                               0.5728                                                                             0.6886                                                                             2.6348                                                                             0.0062                                                                             0.0272                                   5.0394                                                                             -0.2060                                                                            2.6576                                                                             0.0221                                                                             0.0287                                                                               3.9223                                                                             1.4700                                                                             2.6556                                                                             0.0097                                                                             0.0267                                   1.1285                                                                             -0.2338                                                                            2.6583                                                                             0.0239                                                                             0.0293                                                                               2.5091                                                                             0.2165                                                                             2.6402                                                                             0.0126                                                                             0.0280                                   0.1576                                                                             0.2951                                                                             2.6702                                                                             0.0187                                                                             0.0294                                                                               1.3408                                                                             -0.1985                                                                            2.6570                                                                             0.0134                                                                             0.0282                                   1.2466                                                                             -0.8176                                                                            2.6792                                                                             0.0064                                                                             0.0278                                                                               1.6198                                                                             0.1106                                                                             2.6468                                                                             0.0109                                                                             0.0302                                   2.4576                                                                             -0.0801                                                                            2.6384                                                                             0.0149                                                                             0.0279                                                                               0.7543                                                                             1.4660                                                                             2.6470                                                                             0.0075                                                                             0.0293                                   1.4351                                                                             0.4720                                                                             2.6417                                                                             0.0074                                                                             0.0276                                                                               -0.4623                                                                            1.3366                                                                             2.6568                                                                             0.0090                                                                             0.0282                                   2.1705                                                                             0.7970                                                                             2.6685                                                                             0.0061                                                                             0.0272                                                                               2.2284                                                                             0.1388                                                                             2.6479                                                                             0.0115                                                                             0.0295                                   1.9753                                                                             0.9815                                                                             2.6747                                                                             -0.0042                                                                            0.0279                                                                               2.4779                                                                             -0.0747                                                                            2.6465                                                                             0.0072                                                                             0.0287                                   1.6634                                                                             1.7689                                                                             2.6589                                                                             -0.0032                                                                            0.0279                                                                               2.8892                                                                             -0.1678                                                                            2.6614                                                                             0.0001                                                                             0.0298                                   1.8753                                                                             0.2988                                                                             2.6652                                                                             -0.0010                                                                            0.0290                                                                               1.9326                                                                             0.4626                                                                             2.6585                                                                             0.0060                                                                             0.0297                                   2.2568                                                                             0.4001                                                                             2.6539                                                                             0.0113                                                                             0.0285                                                                               1.7998                                                                             -0.1421                                                                            2.6406                                                                             0.0114                                                                             0.0291                                   1.0899                                                                             0.8312                                                                             2.6361                                                                             0.0214                                                                             0.0292                                                                               5.3151                                                                             1.3082                                                                             2.6542                                                                             0.0167                                                                             0.0312                                   1.3405                                                                             0.4590                                                                             2.6207                                                                             0.0219                                                                             0.0285                                                                               3.7844                                                                             0.7163                                                                             2.6363                                                                             0.0140                                                                             0.0300                                   2.2616                                                                             1.2187                                                                             2.6580                                                                             0.0217                                                                             0.0275                                                                               3.9901                                                                             -0.2761                                                                            2.6304                                                                             0.0121                                                                             0.0301                                   2.4213                                                                             0.2571                                                                             2.6402                                                                             0.0222                                                                             0.0268                                                                               3.8605                                                                             0.0214                                                                             2.6637                                                                             0.0103                                                                             0.0292                                   1.8040                                                                             0.0648                                                                             2.6410                                                                             0.0242                                                                             0.0271                                                                               3.0661                                                                             -0.5508                                                                            2.6379                                                                             0.0164                                                                             0.0295                                   3.1152                                                                             0.5659                                                                             2.6365                                                                             0.0180                                                                             0.0265                                                                               2.7208                                                                             -0.0203                                                                            2.6344                                                                             0.0212                                                                             0.0282                                   2.0584                                                                             -0.3071                                                                            2.6531                                                                             0.0144                                                                             0.0269                                                                               0.9973                                                                             -0.4140                                                                            2.6360                                                                             0.0146                                                                             0.0284                                   2.4829                                                                             0.1583                                                                             2.6540                                                                             0.0133                                                                             0.0280                                                                               0.7763                                                                             -0.3762                                                                            2.6833                                                                             0.0106                                                                             0.0276                                   3.0716                                                                             0.3409                                                                             2.6455                                                                             0.0271                                                                             0.0273                                                                               1.0342                                                                             -0.5092                                                                            2.6487                                                                             0.0195                                                                             0.0277                                   2.2086                                                                             -0.0405                                                                            2.6562                                                                             0.0186                                                                             0.0279                                                                               4.2957                                                                             0.5439                                                                             2.6624                                                                             0.0202                                                                             0.0280                                   1.2647                                                                             -0.2818                                                                            2.6556                                                                             0.0214                                                                             0.0276                                                                               1.7571                                                                             0.0614                                                                             2.6254                                                                             0.0325                                                                             0.0282                                   -0.3120                                                                            0.3237                                                                             2.6677                                                                             0.0245                                                                             0.0289                                                                               1.9995                                                                             0.0862                                                                             2.6187                                                                             0.0271                                                                             0.0269                                   1.1265                                                                             -0.4772                                                                            2.6579                                                                             0.0230                                                                             0.0290                                                                               2.8816                                                                             -0.2495                                                                            2.6516                                                                             0.0252                                                                             0.0258                                   6.2250                                                                             -0.6330                                                                            2.6542                                                                             0.0210                                                                             0.0287                                                                               3.3942                                                                             0.9311                                                                             2.6274                                                                             0.0290                                                                             0.0268                                   3.4051                                                                             -0.4863                                                                            2.6628                                                                             0.0152                                                                             0.0292                                                                               5.1002                                                                             2.1636                                                                             2.6527                                                                             0.0221                                                                             0.0277                                   5.6163                                                                             -1.0273                                                                            2.6541                                                                             0.0062                                                                             0.0287                                                                               3.3126                                                                             1.0240                                                                             2.6503                                                                             0.0151                                                                             0.0279                                   3.9738                                                                             -0.9201                                                                            2.6504                                                                             0.0116                                                                             0.0286                                                                               5.0856                                                                             0.7651                                                                             2.6439                                                                             0.0074                                                                             0.0278                                   3.5216                                                                             -0.1981                                                                            2.6332                                                                             0.0123                                                                             0.0282                                                                               2.6226                                                                             0.2481                                                                             2.6559                                                                             0.0038                                                                             0.0278                                   3.8687                                                                             0.2983                                                                             2.6756                                                                             0.0079                                                                             0.0291                                                                               2.4993                                                                             -0.8425                                                                            2.6341                                                                             0.0149                                                                             0.0279                                   2.7837                                                                             0.1007                                                                             2.6690                                                                             0.0009                                                                             0.0275                                                                               2.3059                                                                             -0.1236                                                                            2.6576                                                                             0.0082                                                                             0.0277                                   3.7486                                                                             -0.1015                                                                            2.6623                                                                             0.0039                                                                             0.0269                                                                               1.9314                                                                             1.1583                                                                             2.6462                                                                             0.0043                                                                             0.0272                                   4.4130                                                                             -0.0950                                                                            2.6493                                                                             0.0039                                                                             0.0284                                                                               4.1432                                                                             1.4166                                                                             2.6461                                                                             0.0101                                                                             0.0275                                   3.3456                                                                             1.0716                                                                             2.6524                                                                             0.0088                                                                             0.0275                                                                               1.4722                                                                             0.7197                                                                             2.6469                                                                             0.0095                                                                             0.0275                                   5.7458                                                                             2.1661                                                                             2.6535                                                                             0.0124                                                                             0.0292                                                                               1.7396                                                                             1.1944                                                                             2.6630                                                                             -0.0031                                                                            0.0276                                   3.6741                                                                             1.4704                                                                             2.6537                                                                             0.0095                                                                             0.0265                                                                               0.5433                                                                             1.1531                                                                             2.6608                                                                             0.0088                                                                             0.0273                                   4.6054                                                                             -1.1951                                                                            2.6563                                                                             0.0055                                                                             0.0261                                                                               1.1114                                                                             0.7466                                                                             2.6562                                                                             0.0065                                                                             0.0272                                   0.7481                                                                             0.0589                                                                             2.6654                                                                             0.0098                                                                             0.0279                                                                               2.3006                                                                             -0.3401                                                                            2.6557                                                                             0.0064                                                                             0.0290                                   2.4971                                                                             0.2204                                                                             2.6502                                                                             0.0065                                                                             0.0283                                                                               1.5934                                                                             -0.4329                                                                            2.6604                                                                             0.0098                                                                             0.0282                                   5.1444                                                                             0.9360                                                                             2.6723                                                                             0.0049                                                                             0.0285                                                                               3.9484                                                                             0.7024                                                                             2.6592                                                                             0.0119                                                                             0.0291                                   1.0513                                                                             0.2423                                                                             2.6576                                                                             0.0013                                                                             0.0273                                                                               1.7271                                                                             0.2438                                                                             2.6493                                                                             0.0153                                                                             0.0297                                   3.5246                                                                             -1.2707                                                                            2.6480                                                                             0.0076                                                                             0.0270                                                                               1.3154                                                                             0.4531                                                                             2.6514                                                                             0.0165                                                                             0.0300                                   2.0580                                                                             -0.7626                                                                            2.6468                                                                             0.0014                                                                             0.0277                                                                               0.7342                                                                             -0.3904                                                                            2.6370                                                                             0.0187                                                                             0.0303                                   5.3037                                                                             0.9284                                                                             2.6547                                                                             0.0049                                                                             0.0271                                                                               4.0921                                                                             0.9674                                                                             2.6481                                                                             0.0129                                                                             0.0295                                   1.6737                                                                             -1.8800                                                                            2.6520                                                                             0.0104                                                                             0.0276                                                                               2.0202                                                                             0.5530                                                                             2.6550                                                                             0.0187                                                                             0.0301                                   1.6756                                                                             -0.2589                                                                            2.6692                                                                             0.0122                                                                             0.0251                                                                               5.0239                                                                             1.2197                                                                             2.6395                                                                             0.0243                                                                             0.0273                                   4.8537                                                                             0.2308                                                                             2.6348                                                                             0.0042                                                                             0.0259                                                                               1.9182                                                                             2.1497                                                                             2.6625                                                                             0.0193                                                                             0.0298                                   2.7548                                                                             0.7253                                                                             2.6493                                                                             0.0049                                                                             0.0261                                                                               1.5489                                                                             -0.0431                                                                            2.6333                                                                             0.0167                                                                             0.0281                                   7.3168                                                                             1.7221                                                                             2.6681                                                                             0.0062                                                                             0.0271                                                                               2.8078                                                                             0.4778                                                                             2.6564                                                                             0.0168                                                                             0.0277                                   1.0909                                                                             -0.7174                                                                            2.6533                                                                             -0.0025                                                                            0.0287                                                                               2.4542                                                                             1.6889                                                                             2.6469                                                                             0.0178                                                                             0.0278                                   3.4638                                                                             0.7847                                                                             2.6681                                                                             0.0004                                                                             0.0280                                                                               5.4741                                                                             0.6723                                                                             2.6520                                                                             0.0125                                                                             0.0292                                   1.1741                                                                             0.0114                                                                             2.6588                                                                             -0.0001                                                                            0.0286                                                                               4.4518                                                                             -0.4794                                                                            0.6424                                                                             0.0144                                                                             0.0280                                   0.1926                                                                             0.6597                                                                             2.6373                                                                             0.0062                                                                             0.0282                                                                               0.4142                                                                             0.5643                                                                             2.6588                                                                             0.0126                                                                             0.0273                                   0.2074                                                                             -0.4174                                                                            2.6659                                                                             -0.0013                                                                            0.0276                                                                               1.2884                                                                             -0.7911                                                                            2.6616                                                                             0.0128                                                                             0.0269                                   0.7082                                                                             0.3006                                                                             2.6438                                                                             0.0066                                                                             0.0271                                                                               2.9510                                                                             0.8399                                                                             2.6462                                                                             0.0138                                                                             0.0280                                   2.1632                                                                             0.8803                                                                             2.6584                                                                             0.0134                                                                             0.0264                                                                               5.2756                                                                             0.3397                                                                             2.6589                                                                             0.0187                                                                             0.0269                                   1.6452                                                                             0.4779                                                                             2.6495                                                                             0.0122                                                                             0.0273                                                                               5.1139                                                                             -0.1901                                                                            2.6353                                                                             0.0131                                                                             0.0269                                   2.5861                                                                             0.5153                                                                             2.6494                                                                             0.0133                                                                             0.0274                                                                               5.4041                                                                             0.1544                                                                             2.6249                                                                             0.0121                                                                             0.0270                                   0.5588                                                                             0.6602                                                                             2.6316                                                                             0.0112                                                                             0.0287                                                                               2.8549                                                                             0.2004                                                                             2.6529                                                                             0.0146                                                                             0.0276                                   1.1702                                                                             0.3383                                                                             2.6569                                                                             0.0036                                                                             0.0290                                                                               2.4040                                                                             0.0839                                                                             2.6491                                                                             0.0166                                                                             0.0282                                   1.8428                                                                             -0.6746                                                                            2.6294                                                                             0.0147                                                                             0.0293                                                                               0.9641                                                                             0.0309                                                                             2.6671                                                                             0.0032                                                                             0.0272                                   1.2379                                                                             -0.5478                                                                            2.6402                                                                             0.0103                                                                             0.0271                                                                               2.1573                                                                             0.2211                                                                             2.6359                                                                             -0.0003                                                                            0.0273                                   2.7566                                                                             0.1735                                                                             2.6431                                                                             0.0125                                                                             0.0263                                                                               2.4766                                                                             -0.6345                                                                            2.6505                                                                             0.0095                                                                             0.0284                                   5.2023                                                                             -0.2589                                                                            2.6506                                                                             0.0105                                                                             0.0269                                                                               2.3514                                                                             0.4033                                                                             2.6646                                                                             0.0150                                                                             0.0281                                   1.4437                                                                             0.3557                                                                             2.6452                                                                             0.0104                                                                             0.0274                                                                               0.4769                                                                             -0.2424                                                                            2.6387                                                                             0.0035                                                                             0.0260                                   3.2293                                                                             0.3061                                                                             2.6765                                                                             0.0059                                                                             0.0268                                                                               1.3173                                                                             -0.7170                                                                            2.6517                                                                             0.0106                                                                             0.0271                                   0.3389                                                                             0.6234                                                                             2.6455                                                                             0.0093                                                                             0.0292                                                                               2.4949                                                                             1.0255                                                                             2.6577                                                                             0.0097                                                                             0.0288                                   -0.6021                                                                            0.7865                                                                             2.6506                                                                             0.0058                                                                             0.0290                                                                               0.3930                                                                             2.1710                                                                             2.6455                                                                             0.0148                                                                             0.0290                                   0.2341                                                                             0.4654                                                                             2.6628                                                                             0.0084                                                                             0.0288                                                                               2.8404                                                                             -0.1583                                                                            2.6599                                                                             0.0060                                                                             0.0278                                   -1.6390                                                                            -0.2941                                                                            2.6570                                                                             0.0105                                                                             0.0290                                                                               0.6899                                                                             1.1045                                                                             2.6533                                                                             0.0058                                                                             0.0284                                   1.6630                                                                             0.4140                                                                             2.6576                                                                             0.0163                                                                             0.0282                                                                               1.8179                                                                             -0.5589                                                                            2.6658                                                                             0.0092                                                                             0.0276                                   -1.4057                                                                            0.9888                                                                             2.6432                                                                             0.0159                                                                             0.0266                                                                               2.6599                                                                             -0.8348                                                                            2.6673                                                                             0.0088                                                                             0.0274                                   0.0411                                                                             1.4645                                                                             2.6661                                                                             0.0093                                                                             0.0277                                                                               4.4094                                                                             0.0391                                                                             2.6685                                                                             0.0073                                                                             0.0259                                   2.9795                                                                             0.5006                                                                             2.6626                                                                             0.0131                                                                             0.0273                                                                               3.1961                                                                             0.8577                                                                             2.6224                                                                             0.0120                                                                             0.0280                                   5.5393                                                                             1.7395                                                                             2.6454                                                                             0.0186                                                                             0.0272                                                                               2.5163                                                                             0.5533                                                                             2.6263                                                                             0.0197                                                                             0.0293                                   4.1986                                                                             -1.2595                                                                            2.6344                                                                             0.0184                                                                             0.0262                                                                               2.3859                                                                             1.0875                                                                             2.6658                                                                             0.0086                                                                             0.0283                                   3.7823                                                                             -0.6545                                                                            2.6596                                                                             0.0133                                                                             0.0273                                                                               1.4727                                                                             1.2611                                                                             2.6517                                                                             0.0037                                                                             0.0267                                   1.6472                                                                             -0.6402                                                                            2.6404                                                                             0.0239                                                                             0.0279                                                                               3.2515                                                                             0.9088                                                                             2.6442                                                                             0.0182                                                                             0.0267                                   6.5593                                                                             1.1958                                                                             2.6463                                                                             0.0222                                                                             0.0284                                                                               4.5539                                                                             1.0301                                                                             2.6465                                                                             0.0206                                                                             0.0276                                   3.6094                                                                             1.5731                                                                             2.6440                                                                             0.0096                                                                             0.0295                                                                               5.9524                                                                             0.4144                                                                             2.6449                                                                             0.0184                                                                             0.0277                                   3.7812                                                                             2.1883                                                                             2.6481                                                                             0.0044                                                                             0.0290                                                                               6.1258                                                                             0.0342                                                                             2.6620                                                                             0.0122                                                                             0.0286                                   4.4263                                                                             1.8294                                                                             2.6459                                                                             0.0057                                                                             0.0283                                                                               6.6355                                                                             -0.5733                                                                            2.6144                                                                             0.0196                                                                             0.0271                                   4.9112                                                                             3.0428                                                                             2.6458                                                                             0.0099                                                                             0.0288                                                                               4.4364                                                                             -0.0096                                                                            2.6472                                                                             0.0195                                                                             0.0265                                   2.7827                                                                             2.6269                                                                             2.6308                                                                             0.0190                                                                             0.0294                                                                               3.3822                                                                             0.4706                                                                             2.6532                                                                             0.0124                                                                             0.0280                                   4.1157                                                                             -0.2270                                                                            2.6573                                                                             0.0071                                                                             0.0274                                                                               -0.5750                                                                            0.4658                                                                             2.6536                                                                             0.0122                                                                             0.0280                                   2.5359                                                                             1.6700                                                                             2.6441                                                                             0.0143                                                                             0.0281                                                                               -1.4322                                                                            1.2392                                                                             2.6708                                                                             0.0037                                                                             0.0274                                   2.4012                                                                             0.1917                                                                             2.6431                                                                             0.0034                                                                             0.0267                                                                               2.1764                                                                             2.1806                                                                             2.6670                                                                             0.0032                                                                             0.0276                                   4.8764                                                                             -0.6363                                                                            2.6352                                                                             0.0048                                                                             0.0273                                                                               0.4389                                                                             0.9985                                                                             2.6450                                                                             0.0080                                                                             0.0276                                   1.0126                                                                             -0.3540                                                                            2.6516                                                                             -0.0053                                                                            0.0272                                                                               -2.3457                                                                            0.7739                                                                             2.6617                                                                             0.0074                                                                             0.0269                                   1.3119                                                                             -0.6050                                                                            2.6786                                                                             -0.0028                                                                            0.0277                                                                               -0.2867                                                                            0.4845                                                                             2.6613                                                                             -0.0071                                                                            0.0279                                   2.5003                                                                             -0.4723                                                                            2.6399                                                                             0.0055                                                                             0.0280                                                                               -0.3643                                                                            0.5095                                                                             2.6407                                                                             -0.0178                                                                            0.0273                                   2.0027                                                                             0.3019                                                                             2.6597                                                                             0.0087                                                                             0.0282                                                                               -0.0560                                                                            0.3752                                                                             2.6588                                                                             0.0007                                                                             0.0283                                   1.4444                                                                             -0.0868                                                                            2.6602                                                                             0.0109                                                                             0.0278                                                                               3.9491                                                                             0.1921                                                                             2.6622                                                                             0.0067                                                                             0.0278                                   4.5706                                                                             0.6752                                                                             2.6332                                                                             0.0218                                                                             0.0269                                                                               3.4450                                                                             0.4169                                                                             2.6443                                                                             0.0027                                                                             0.0276                                   1.4238                                                                             0.3784                                                                             2.6345                                                                             0.0229                                                                             0.0284                                                                               3.6594                                                                             -0.1030                                                                            2.6640                                                                             0.0167                                                                             0.0278                                   2.6803                                                                             -0.4080                                                                            2.6470                                                                             0.0205                                                                             0.0303                                                                               3.6901                                                                             0.7143                                                                             2.6462                                                                             0.0137                                                                             0.0266                                   3.2681                                                                             0.3190                                                                             2.6302                                                                             0.0234                                                                             0.0280                                                                               3.5109                                                                             1.1141                                                                             2.6585                                                                             0.0083                                                                             0.0262                                   4.4241                                                                             0.9761                                                                             2.6497                                                                             0.0220                                                                             0.0271                                                                               3.2343                                                                             0.7636                                                                             2.6690                                                                             0.0129                                                                             0.0266                                   6.9269                                                                             1.2038                                                                             2.6470                                                                             0.0137                                                                             0.0263                                                                               1.9397                                                                             0.4829                                                                             2.6602                                                                             0.0111                                                                             0.0275                                   4.7181                                                                             0.7996                                                                             2.6314                                                                             0.0177                                                                             0.0274                                                                               2.2792                                                                             0.3657                                                                             2.6454                                                                             0.0152                                                                             0.0272                                   3.6084                                                                             -0.2809                                                                            2.6387                                                                             0.0123                                                                             0.0286                                                                               2.3775                                                                             -0.5988                                                                            2.6671                                                                             0.0178                                                                             0.0275                                   0.9427                                                                             0.1676                                                                             2.6629                                                                             0.0082                                                                             0.0274                                                                               2.0547                                                                             -0.0878                                                                            2.6387                                                                             0.0192                                                                             0.0282                                   2.4099                                                                             0.4064                                                                             2.6317                                                                             0.0104                                                                             0.0270                                                                               1.0545                                                                             0.0378                                                                             2.6475                                                                             0.0141                                                                             0.0292                                   1.0040                                                                             0.2873                                                                             2.6521                                                                             0.0081                                                                             0.0271                                                                               1.3411                                                                             0.1698                                                                             2.6475                                                                             0.0165                                                                             0.0281                                   0.5834                                                                             0.2850                                                                             2.6499                                                                             0.0027                                                                             0.0285                                                                               2.6481                                                                             -0.4131                                                                            2.6468                                                                             0.0163                                                                             0.0272                                   1.6207                                                                             -0.1592                                                                            2.6608                                                                             0.0076                                                                             0.0288                                                                               4.6923                                                                             0.4920                                                                             2.6248                                                                             0.0195                                                                             0.0260                                   4.0428                                                                             -0.3196                                                                            2.6460                                                                             0.0045                                                                             0.0289                                                                               3.1451                                                                             0.2122                                                                             2.6667                                                                             0.0130                                                                             0.0261                                   2.1667                                                                             -0.4218                                                                            2.6241                                                                             0.0025                                                                             0.0286                                                                               3.8535                                                                             2.6115                                                                             2.6649                                                                             0.0093                                                                             0.0253                                   3.6067                                                                             0.4782                                                                             2.6547                                                                             0.0041                                                                             0.0278                                                                               4.1541                                                                             -0.0261                                                                            2.6542                                                                             0.0079                                                                             0.0262                                   1.9123                                                                             0.3994                                                                             2.6453                                                                             0.0121                                                                             0.0283                                                                               4.0195                                                                             1.1967                                                                             2.6624                                                                             0.0104                                                                             0.0279                                   3.8838                                                                             -0.4143                                                                            2.6584                                                                             0.0088                                                                             0.0286                                                                               2.2126                                                                             0.7001                                                                             2.6676                                                                             0.0150                                                                             0.0280                                   2.1482                                                                             -0.3200                                                                            2.6503                                                                             0.0193                                                                             0.0294                                                                               1.4314                                                                             -0.3612                                                                            2.6465                                                                             0.0129                                                                             0.0275                                   2.7011                                                                             -0.1556                                                                            2.6488                                                                             0.0186                                                                             0.0288                                                                               0.2025                                                                             1.5073                                                                             2.6473                                                                             0.0084                                                                             0.0277                                   3.0142                                                                             1.7930                                                                             2.6649                                                                             0.0125                                                                             0.0269                                                                               1.5865                                                                             -0.4884                                                                            2.6270                                                                             0.0167                                                                             0.0266                                   2.0626                                                                             -0.2325                                                                            2.6486                                                                             0.0145                                                                             0.0266                                                                               2.6630                                                                             -0.3758                                                                            2.6378                                                                             0.0156                                                                             0.0270                                   1.3075                                                                             0.0367                                                                             2.6419                                                                             0.0203                                                                             0.0275                                                                               5.1488                                                                             -0.1241                                                                            2.6533                                                                             0.0221                                                                             0.0280                                   3.2476                                                                             -0.5700                                                                            2.6382                                                                             0.0236                                                                             0.0277                                                                               5.6596                                                                             -0.3814                                                                            2.6444                                                                             0.0216                                                                             0.0278                                   4.8414                                                                             -0.4105                                                                            2.6651                                                                             0.0172                                                                             0.0284                                                                               5.4980                                                                             -0.6379                                                                            2.6626                                                                             0.0199                                                                             0.0283                                   2.1621                                                                             0.0915                                                                             2.6599                                                                             0.0131                                                                             0.0282                                                                               3.0443                                                                             0.5816                                                                             2.6492                                                                             0.0168                                                                             0.0281                                   3.9532                                                                             0.3748                                                                             2.6817                                                                             0.0049                                                                             0.0277                                                                               2.6895                                                                             -0.1860                                                                            2.6437                                                                             0.0183                                                                             0.0270                                   1.9418                                                                             -0.0814                                                                            2.6667                                                                             0.0076                                                                             0.0281                                                                               1.7831                                                                             -0.9372                                                                            2.6652                                                                             0.0118                                                                             0.0261                                   2.6563                                                                             0.5933                                                                             2.6197                                                                             0.0131                                                                             0.0274                                                                               3.8252                                                                             0.2824                                                                             2.6552                                                                             0.0180                                                                             0.0262                                   2.8363                                                                             0.2643                                                                             2.6462                                                                             0.0183                                                                             0.0268                                                                               2.9598                                                                             0.2530                                                                             2.6620                                                                             0.0123                                                                             0.0260                                   0.5135                                                                             0.5905                                                                             2.6694                                                                             0.0127                                                                             0.0277                                                                               1.8252                                                                             0.6973                                                                             2.6502                                                                             0.0085                                                                             0.0263                                   5.2928                                                                             0.6642                                                                             2.6624                                                                             0.0111                                                                             0.0272                                                                               2.2487                                                                             0.6812                                                                             2.6900                                                                             0.0063                                                                             0.0264                                   1.7432                                                                             0.2334                                                                             2.6577                                                                             0.0169                                                                             0.0273                                                                               5.0761                                                                             1.8561                                                                             2.6568                                                                             0.0159                                                                             0.0272                                   3.4760                                                                             0.6209                                                                             2.6478                                                                             0.0132                                                                             0.0282                                                                               0.4468                                                                             0.3913                                                                             2.6383                                                                             0.0281                                                                             0.0277                                   0.7206                                                                             0.6170                                                                             2.6557                                                                             0.0170                                                                             0.0272                                                                               2.9688                                                                             0.5846                                                                             2.6603                                                                             0.0165                                                                             0.0283                                   -0.2979                                                                            0.0385                                                                             2.6415                                                                             0.0174                                                                             0.0275                                                                               3.9400                                                                             1.4588                                                                             2.6787                                                                             0.0112                                                                             0.0268                                   2.6450                                                                             0.3160                                                                             2.6622                                                                             0.0165                                                                             0.0276                                                                               2.4346                                                                             1.2917                                                                             2.6565                                                                             0.0122                                                                             0.0269                                   3.0699                                                                             0.4915                                                                             2.6527                                                                             0.0214                                                                             0.0270                                                                               1.5787                                                                             1.1059                                                                             2.6455                                                                             0.0093                                                                             0.0270                                   2.4165                                                                             0.4811                                                                             2.6536                                                                             0.0196                                                                             0.0291                                                                               -0.5695                                                                            1.0801                                                                             2.6330                                                                             0.0252                                                                             0.0274                                   1.8736                                                                             1.5841                                                                             2.6406                                                                             0.0131                                                                             0.0288                                                                               -0.3294                                                                            1.0115                                                                             2.6532                                                                             0.0284                                                                             0.0268                                   3.6034                                                                             2.0621                                                                             2.6645                                                                             0.0154                                                                             0.0278                                                                               3.3528                                                                             2.7957                                                                             2.6434                                                                             0.0316                                                                             0.0264                                   4.2998                                                                             -0.0787                                                                            2.6480                                                                             0.0200                                                                             0.0276                                                                               -0.0093                                                                            0.8596                                                                             2.6430                                                                             0.0164                                                                             0.0256                                   3.9555                                                                             -0.1884                                                                            2.6409                                                                             0.0226                                                                             0.0292                                                                               2.0246                                                                             0.6432                                                                             2.6418                                                                             0.0099                                                                             0.0266                                   0.8139                                                                             -0.5540                                                                            2.6455                                                                             0.1080                                                                             0.0284                                                                               4.5836                                                                             1.4561                                                                             2.6522                                                                             0.0088                                                                             0.0285                                   2.1694                                                                             0.1378                                                                             2.6475                                                                             0.0088                                                                             0.0272                                                                               3.2806                                                                             -0.2098                                                                            2.6533                                                                             0.0053                                                                             0.0275                                   1.7707                                                                             -0.2607                                                                            2.6234                                                                             0.0071                                                                             0.0279                                                                               2.7829                                                                             0.0721                                                                             2.6382                                                                             0.0068                                                                             0.0286                                   0.9334                                                                             0.2441                                                                             2.6675                                                                             0.0052                                                                             0.0298                                                                               1.6528                                                                             1.0183                                                                             2.6706                                                                             0.0065                                                                             0.0295                                   3.6275                                                                             0.5285                                                                             2.6454                                                                             0.0178                                                                             0.0289                                                                               4.1942                                                                             -0.8104                                                                            2.6520                                                                             0.0119                                                                             0.0315                                   1.4500                                                                             0.1172                                                                             2.6353                                                                             0.0211                                                                             0.0277                                                                               2.0121                                                                             -0.4914                                                                            2.6409                                                                             -0.0008                                                                            0.0304                                   1.4600                                                                             0.4299                                                                             2.6527                                                                             0.0177                                                                             0.0269                                                                               2.4689                                                                             -0.0827                                                                            2.6340                                                                             0.0046                                                                             0.0300                                   4.9627                                                                             0.1185                                                                             2.6516                                                                             0.0168                                                                             0.0263                                                                               2.3457                                                                             0.1073                                                                             2.6686                                                                             0.0115                                                                             0.0302                                   0.9015                                                                             0.9547                                                                             2.6692                                                                             0.0163                                                                             0.0265                                                                               1.6948                                                                             0.0577                                                                             2.6593                                                                             0.0117                                                                             0.0303                                   2.8402                                                                             0.2038                                                                             2.6636                                                                             0.0211                                                                             0.0268                                                                               2.1291                                                                             -0.1984                                                                            2.6471                                                                             0.0138                                                                             0.0289                                   1.1254                                                                             -0.7338                                                                            2.6458                                                                             0.0200                                                                             0.0269                                                                               2.2774                                                                             0.0914                                                                             2.6572                                                                             -0.0024                                                                            0.0288                                   1.3064                                                                             -0.6939                                                                            2.6454                                                                             0.0168                                                                             0.0269                                                                               2.7512                                                                             1.2060                                                                             2.6759                                                                             0.0016                                                                             0.0279                                   1.8746                                                                             -0.0730                                                                            2.6520                                                                             0.0175                                                                             0.0269                                                                               1.8297                                                                             3.3518                                                                             2.6525                                                                             0.0217                                                                             0.0290                                   2.3129                                                                             0.1293                                                                             2.6475                                                                             0.0139                                                                             0.0273                                                                               5.7326                                                                             -0.4421                                                                            2.6488                                                                             0.0238                                                                             0.0280                                   6.1266                                                                             -0.1203                                                                            2.6247                                                                             0.0163                                                                             0.0283                                                                               3.9727                                                                             0.3677                                                                             2.6347                                                                             0.0191                                                                             0.0297                                   -0.0478                                                                            0.3266                                                                             2.6509                                                                             0.0221                                                                             0.0273                                                                               2.5277                                                                             0.8634                                                                             2.6439                                                                             0.0163                                                                             0.0301                                   -0.8435                                                                            0.1195                                                                             2.6629                                                                             0.0188                                                                             0.0277                                                                               0.0264                                                                             0.6821                                                                             2.6406                                                                             0.0108                                                                             0.0310                                   1.1221                                                                             -0.0635                                                                            2.6473                                                                             0.0159                                                                             0.0278                                                                               1.0718                                                                             1.5789                                                                             2.6484                                                                             0.0127                                                                             0.0298                                   1.1601                                                                             -1.3225                                                                            2.6767                                                                             0.0035                                                                             0.0276                                                                               5.5419                                                                             0.7405                                                                             2.6412                                                                             0.0198                                                                             0.0295                                   1.5515                                                                             0.4051                                                                             2.6584                                                                             0.0124                                                                             0.0266                                                                               3.1541                                                                             0.8144                                                                             2.6338                                                                             0.0177                                                                             0.0287                                   5.4314                                                                             0.5687                                                                             2.6316                                                                             0.0144                                                                             0.0268                                                                               2.5033                                                                             0.8817                                                                             2.6274                                                                             0.0187                                                                             0.0294                                   6.4706                                                                             0.7109                                                                             2.6748                                                                             0.0160                                                                             0.0276                                                                               4.0518                                                                             -0.0335                                                                            2.6594                                                                             0.0183                                                                             0.0284                                   5.6930                                                                             1.3410                                                                             2.6381                                                                             0.0182                                                                             0.0278                                                                               3.9070                                                                             0.3701                                                                             2.6492                                                                             0.0207                                                                             0.0279                                   4.0447                                                                             -0.3637                                                                            2.6544                                                                             0.0117                                                                             0.0299                                                                               3.8873                                                                             -0.3868                                                                            2.6391                                                                             0.0194                                                                             0.0276                                   2.4545                                                                             -0.0489                                                                            2.6662                                                                             0.0071                                                                             0.0296                                                                               -2.2341                                                                            1.6680                                                                             2.6553                                                                             0.0147                                                                             0.0262                                   1.2373                                                                             0.6740                                                                             2.6491                                                                             0.0172                                                                             0.0292                                                                               1.7356                                                                             0.2896                                                                             2.6477                                                                             0.0157                                                                             0.0273                                   2.0195                                                                             -0.5999                                                                            2.6366                                                                             0.0181                                                                             0.0294                                                                               1.4002                                                                             0.8415                                                                             2.6297                                                                             0.0208                                                                             0.0282                                   0.0648                                                                             -0.1082                                                                            2.6527                                                                             0.0120                                                                             0.0286                                                                               3.6738                                                                             1.3182                                                                             2.6398                                                                             0.0117                                                                             0.0274                                   -1.1825                                                                            -0.1007                                                                            2.6473                                                                             0.0103                                                                             0.0275                                                                               2.9344                                                                             0.0889                                                                             2.6308                                                                             0.0115                                                                             0.0287                                   -0.1409                                                                            0.7261                                                                             2.6265                                                                             0.0055                                                                             0.0282                                                                               0.5870                                                                             0.0361                                                                             2.6712                                                                             0.0100                                                                             0.0277                                   1.0857                                                                             0.2146                                                                             2.6571                                                                             0.0051                                                                             0.0266                                                                               5.1135                                                                             1.5940                                                                             2.6726                                                                             0.0002                                                                             0.0271                                   0.2192                                                                             0.5772                                                                             2.6316                                                                             0.0193                                                                             0.0284                                                                               1.3554                                                                             0.4734                                                                             2.6490                                                                             0.0081                                                                             0.0257                                   1.2993                                                                             1.0382                                                                             2.6388                                                                             0.0217                                                                             0.0275                                                                               2.0718                                                                             0.2522                                                                             2.6608                                                                             0.0155                                                                             0.0257                                   0.6346                                                                             1.4641                                                                             2.6587                                                                             0.0164                                                                             0.0272                                                                               1.9363                                                                             -0.2471                                                                            2.6596                                                                             0.0073                                                                             0.0265                                   1.3008                                                                             1.7269                                                                             2.6524                                                                             0.0092                                                                             0.0262                                                                               0.0539                                                                             -0.4363                                                                            2.6492                                                                             0.0176                                                                             0.0287                                   3.0064                                                                             1.5901                                                                             2.6622                                                                             0.0198                                                                             0.0273                                                                               0.5551                                                                             -0.1603                                                                            2.6342                                                                             0.0189                                                                             0.0277                                   1.4510                                                                             1.4926                                                                             2.6516                                                                             0.0084                                                                             0.0278                                                                               3.5215                                                                             0.6926                                                                             2.6343                                                                             0.0172                                                                             0.0278                                   1.9123                                                                             0.3994                                                                             2.6453                                                                             0.0121                                                                             0.0283                                                                               4.0195                                                                             1.1967                                                                             2.6624                                                                             0.0104                                                                             0.0279                                   3.8838                                                                             -0.4143                                                                            2.6584                                                                             0.0088                                                                             0.0286                                                                               2.2126                                                                             0.7001                                                                             2.6676                                                                             0.0150                                                                             0.0280                                   2.1482                                                                             -0.3200                                                                            2.6503                                                                             0.0193                                                                             0.0294                                                                               1.4314                                                                             -0.3612                                                                            2.6465                                                                             0.0129                                                                             0.0275                                   2.7011                                                                             -0.1556                                                                            2.6488                                                                             0.0186                                                                             0.0288                                                                               0.2025                                                                             1.5073                                                                             2.6473                                                                             0.0084                                                                             0.0277                                   3.0142                                                                             1.7930                                                                             2.6649                                                                             0.0125                                                                             0.0269                                                                               1.5765                                                                             -0.4884                                                                            2.6270                                                                             0.0167                                                                             0.0266                                   2.0626                                                                             -0.2325                                                                            2.6486                                                                             0.0145                                                                             0.0266                                                                               2.6630                                                                             -0.3758                                                                            2.6378                                                                             0.0156                                                                             0.0270                                   1.3075                                                                             0.0367                                                                             2.6419                                                                             0.0203                                                                             0.0275                                                                               5.1488                                                                             -0.1241                                                                            2.6533                                                                             0.0221                                                                             0.0280                                   3.2476                                                                             -0.5700                                                                            2.6382                                                                             0.0236                                                                             0.0277                                                                               5.6596                                                                             -0.3814                                                                            2.6444                                                                             0.0216                                                                             0.0278                                   4.8414                                                                             -0.4105                                                                            2.6651                                                                             0.0172                                                                             0.0284                                                                               5.4980                                                                             -0.6379                                                                            2.6626                                                                             0.0199                                                                             0.0283                                   2.1621                                                                             0.0915                                                                             2.6599                                                                             0.0131                                                                             0.0282                                                                               3.0443                                                                             0.5816                                                                             2.6492                                                                             0.0168                                                                             0.0281                                   3.9532                                                                             0.3748                                                                             2.6817                                                                             0.0049                                                                             0.0277                                                                               2.6895                                                                             -0.1860                                                                            2.6437                                                                             0.0183                                                                             0.0270                                   1.9418                                                                             -0.0814                                                                            2.6667                                                                             0.0076                                                                             0.0281                                                                               1.7831                                                                             -0.9372                                                                            2.6652                                                                             0.0118                                                                             0.0261                                   2.6563                                                                             0.5933                                                                             2.6197                                                                             0.0131                                                                             0.0274                                                                               3.8252                                                                             0.2824                                                                             2.6552                                                                             0.0180                                                                             0.0262                                   2.8363                                                                             0.2643                                                                             2.6462                                                                             0.0183                                                                             0.0268                                                                               2.9598                                                                             0.2530                                                                             2.6620                                                                             0.0123                                                                             0.0260                                   0.5135                                                                             0.5905                                                                             2.6694                                                                             0.0127                                                                             0.0277                                                                               1.8252                                                                             0.6973                                                                             2.6502                                                                             0.0085                                                                             0.0263                                   5.2928                                                                             0.6642                                                                             2.6624                                                                             0.0111                                                                             0.0272                                                                               2.4287                                                                             0.6812                                                                             2.6900                                                                             0.0063                                                                             0.0264                                   1.7432                                                                             0.2334                                                                             2.6577                                                                             0.0169                                                                             0.0273                                                                               5.0761                                                                             1.8561                                                                             2.6568                                                                             0.0159                                                                             0.0272                                   3.4760                                                                             0.6209                                                                             2.6478                                                                             0.0132                                                                             0.0282                                                                               0.4468                                                                             0.3913                                                                             2.6383                                                                             0.0281                                                                             0.0277                                   0.7206                                                                             0.6170                                                                             2.6557                                                                             0.0170                                                                             0.0272                                                                               2.9688                                                                             0.5846                                                                             2.6603                                                                             0.0165                                                                             0.0283                                   -0.2979                                                                            0.0385                                                                             2.6415                                                                             0.0174                                                                             0.0275                                                                               3.9400                                                                             1.4588                                                                             2.6787                                                                             0.0112                                                                             0.0268                                   2.6450                                                                             0.3160                                                                             2.6622                                                                             0.0165                                                                             0.0276                                                                               2.4346                                                                             1.2917                                                                             2.6565                                                                             0.0122                                                                             0.0269                                   3.0699                                                                             0.4915                                                                             2.6527                                                                             0.0214                                                                             0.0270                                                                               1.5787                                                                             1.0159                                                                             2.6455                                                                             0.0093                                                                             0.0270                                   2.4165                                                                             0.4811                                                                             2.6536                                                                             0.0196                                                                             0.0291                                                                               -0.5695                                                                            1.0801                                                                             2.6330                                                                             0.0252                                                                             0.0274                                   1.8736                                                                             1.5841                                                                             2.6406                                                                             0.0131                                                                             0.0288                                                                               -0.3294                                                                            1.0115                                                                             2.6532                                                                             0.0284                                                                             0.0268                                   3.6034                                                                             2.0621                                                                             2.6645                                                                             0.0154                                                                             0.0278                                                                               3.3528                                                                             2.7957                                                                             2.6434                                                                             0.0316                                                                             0.0264                                   4.2998                                                                             -0.0787                                                                            2.6480                                                                             0.0200                                                                             0.0276                                                                               -0.0093                                                                            0.8596                                                                             2.6430                                                                             0.0164                                                                             0.0256                                   3.9555                                                                             -0.1884                                                                            2.6409                                                                             0.0226                                                                             0.0292                                                                               2.0246                                                                             0.6432                                                                             2.6418                                                                             0.0099                                                                             0.0266                                   0.8139                                                                             -0.5540                                                                            2.6455                                                                             0.0180                                                                             0.0284                                                                               4.5836                                                                             1.4561                                                                             2.6522                                                                             0.0088                                                                             0.0285                                   2.1694                                                                             0.1378                                                                             2.6475                                                                             0.0088                                                                             0.0272                                                                               3.2806                                                                             -0.2098                                                                            2.6533                                                                             0.0053                                                                             0.0275                                   1.7707                                                                             -2.2607                                                                            2.6234                                                                             0.0071                                                                             0.0279                                                                               2.7829                                                                             0.0721                                                                             2.6382                                                                             0.0068                                                                             0.0286                                   0.9334                                                                             0.2441                                                                             2.6775                                                                             0.0052                                                                             0.0298                                                                               1.6528                                                                             1.0183                                                                             2.6706                                                                             0.0065                                                                             0.0295                                   3.6275                                                                             0.5285                                                                             2.6454                                                                             0.0178                                                                             0.0289                                                                               4.1942                                                                             -0.8104                                                                            2.6520                                                                             0.0119                                                                             0.0315                                   1.4500                                                                             0.1172                                                                             2.6353                                                                             0.0211                                                                             0.0277                                                                               2.0121                                                                             -0.4914                                                                            2.6409                                                                             -0.0008                                                                            0.0304                                   1.4600                                                                             0.4299                                                                             2.6527                                                                             0.0177                                                                             0.0269                                                                               2.4689                                                                             -0.0827                                                                            2.6340                                                                             0.0046                                                                             0.0300                                   4.9627                                                                             0.1185                                                                             2.6516                                                                             0.0168                                                                             0.0263                                                                               2.3457                                                                             0.1073                                                                             2.6686                                                                             0.0115                                                                             0.0302                                   0.9015                                                                             0.9547                                                                             2.6692                                                                             0.0163                                                                             0.0265                                                                               1.6948                                                                             0.0577                                                                             2.6593                                                                             0.0117                                                                             0.0303                                   2.8402                                                                             0.2038                                                                             2.6636                                                                             0.0211                                                                             0.0268                                                                               2.1291                                                                             -0.1984                                                                            2.6471                                                                             0.0138                                                                             0.0289                                   1.1254                                                                             -0.7338                                                                            2.6458                                                                             0.0200                                                                             0.0269                                                                               2.2774                                                                             0.0914                                                                             2.6572                                                                             -0.0024                                                                            0.0288                                   1.3064                                                                             -0.6939                                                                            2.6454                                                                             0.0168                                                                             0.0269                                                                               2.7512                                                                             1.2060                                                                             2.6759                                                                             0.0016                                                                             0.0279                                   1.8746                                                                             -0.0730                                                                            2.6520                                                                             0.0175                                                                             0.0269                                                                               1.8297                                                                             3.3518                                                                             2.6525                                                                             0.0217                                                                             0.0290                                   2.3129                                                                             0.1293                                                                             2.6475                                                                             0.0139                                                                             0.0273                                                                               5.7326                                                                             -0.4421                                                                            2.6488                                                                             0.0238                                                                             0.0280                                   6.1266                                                                             -0.1203                                                                            2.6247                                                                             0.0163                                                                             0.0283                                                                               3.9727                                                                             0.3677                                                                             2.6347                                                                             0.0191                                                                             0.0297                                   -0.0478                                                                            0.3266                                                                             2.6509                                                                             0.0221                                                                             0.0273                                                                               2.5277                                                                             0.8634                                                                             2.6439                                                                             0.0163                                                                             0.0301                                   -0.8435                                                                            0.1195                                                                             2.6629                                                                             0.0188                                                                             0.0277                                                                               0.0264                                                                             0.6821                                                                             2.6406                                                                             0.0108                                                                             0.0310                                   1.1221                                                                             -0.0635                                                                            2.6473                                                                             0.0159                                                                             0.0278                                                                               1.0718                                                                             1.589                                                                              2.6484                                                                             0.0127                                                                             0.0298                                   1.1601                                                                             -1.3225                                                                            2.6767                                                                             0.0035                                                                             0.0276                                                                               5.5419                                                                             0.05                                                                               2.6412                                                                             0.0198                                                                             0.0295                                   1.5515                                                                             0.4051                                                                             2.6584                                                                             0.0124                                                                             0.0266                                                                               3.1541                                                                             0.8144                                                                             2.6338                                                                             0.0177                                                                             0.0287                                   5.4314                                                                             0.5687                                                                             2.6316                                                                             0.0144                                                                             0.0268                                                                               2.5033                                                                             0.8817                                                                             2.6274                                                                             0.0187                                                                             0.0294                                   6.4706                                                                             0.7109                                                                             2.6748                                                                             0.0160                                                                             0.0276                                                                               4.0518                                                                             -0.0335                                                                            2.6594                                                                             0.0183                                                                             0.0284                                   5.6930                                                                             1.3410                                                                             2.6381                                                                             0.0182                                                                             0.0278                                                                               3.9070                                                                             0.3701                                                                             2.6492                                                                             0.0207                                                                             0.0279                                   4.0447                                                                             -0.3637                                                                            2.6544                                                                             0.0117                                                                             0.0299                                                                               3.8873                                                                             -0.3868                                                                            2.6391                                                                             0.0194                                                                             0.0276                                   2.4545                                                                             -0.0489                                                                            2.6662                                                                             0.0071                                                                             0.0296                                                                               -2.2341                                                                            1.6680                                                                             2.6553                                                                             0.0147                                                                             0.0262                                   1.2373                                                                             0.6740                                                                             2.6491                                                                             0.0172                                                                             0.0292                                                                               1.7356                                                                             0.2896                                                                             2.6477                                                                             0.0157                                                                             0.0273                                   2.0195                                                                             -0.5999                                                                            2.6366                                                                             0.0181                                                                             0.0294                                                                               1.4002                                                                             0.8415                                                                             2.6297                                                                             0.0208                                                                             0.0282                                   0.0648                                                                             -0.1082                                                                            2.6527                                                                             0.0120                                                                             0.0286                                                                               3.6738                                                                             1.3182                                                                             2.6398                                                                             0.0117                                                                             0.0274                                   -1.1825                                                                            -0.1007                                                                            2.6473                                                                             0.0103                                                                             0.0275                                                                               2.9344                                                                             0.0889                                                                             2.6308                                                                             0.0115                                                                             0.0287                                   -0.1409                                                                            0.7261                                                                             2.6265                                                                             0.0055                                                                             0.0282                                                                               0.5870                                                                             0.0361                                                                             2.6712                                                                             0.0100                                                                             0.0277                                   1.0857                                                                             0.2146                                                                             2.6571                                                                             0.0051                                                                             0.0266                                                                               5.1135                                                                             1.5940                                                                             2.6726                                                                             0.0002                                                                             0.0271                                   0.2192                                                                             0.5772                                                                             2.6316                                                                             0.0193                                                                             0.0284                                                                               1.3554                                                                             0.4734                                                                             2.6490                                                                             0.0081                                                                             0.0257                                   1.2993                                                                             1.0382                                                                             2.6388                                                                             0.0217                                                                             0.0275                                                                               2.0718                                                                             0.2522                                                                             2.6608                                                                             0.0155                                                                             0.0257                                   0.6346                                                                             1.4641                                                                             2.6587                                                                             0.0164                                                                             0.0272                                                                               1.9363                                                                             -0.2471                                                                            2.6596                                                                             0.0073                                                                             0.0265                                   1.3008                                                                             1.7269                                                                             2.6524                                                                             0.0092                                                                             0.0262                                                                               0.0539                                                                             -0.4363                                                                            2.6492                                                                             0.0176                                                                             0.0287                                   3.0064                                                                             1.5901                                                                             2.6622                                                                             0.0198                                                                             0.0273                                                                               0.5551                                                                             -0.1603                                                                            2.6342                                                                             0.0189                                                                             0.0277                                   1.4510                                                                             1.4926                                                                             2.6516                                                                             0.0084                                                                             0.0278                                                                               3.5215                                                                             0.6926                                                                             2.6343                                                                             0.0172                                                                             0.0278                                                         3.9633                                                                             -0.1382                                                                            2.6665                                                                             0.0137                                                                             0.0283                                                         3.7216                                                                             0.3433                                                                             2.6561                                                                             0.0097                                                                             0.0271                                                         0.3863                                                                             0.7137                                                                             2.6480                                                                             0.0106                                                                             0.0270                                                         1.7291                                                                             1.5199                                                                             2.6464                                                                             0.0089                                                                             0.0276                                                         5.8988                                                                             1.5338                                                                             2.6524                                                                             0.0108                                                                             0.0286                                                         -0.0662                                                                            0.3417                                                                             2.6596                                                                             0.0214                                                                             0.0293                                                         3.2610                                                                             -0.9585                                                                            2.6446                                                                             0.0203                                                                             0.0290                                                         0.9132                                                                             1.0255                                                                             2.6486                                                                             0.0242                                                                             0.0284                                   __________________________________________________________________________

Equivalents

While the invention has been particularly shown and described with reference to a preferred embodiment thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined in the claims. 

What is claimed is:
 1. A method of assessing the risk of an individual for a disease, comprising:a) testing the individual to detect a level of a marker for the disease; b) computing risk of disease from a detected level of the marker; and c) comparing the computed risk to thresholds to triage the individual into one of normal, borderline and elevated risk groups,wherein if the individual is triaged to a borderline risk group, the step of testing the individual to detect the level of the marker is repeated at a retest interval substantially less than a routine screening interval.
 2. A method as claimed in claim 1, wherein if the individual is triaged to a normal risk group, the step of testing the individual to detect the level of the marker is repeated at a routine screening interval.
 3. A method as claimed in claim 1, wherein if the individual is again triaged to a borderline risk group upon repeat testing, the step of testing the individual is again repeated to detect the level of the marker at a retest interval substantially less than a routine screening interval.
 4. A method as claimed in claim 1 wherein the retest interval is inversely related to the computed risk.
 5. A method as claimed in claim 1 wherein, if the individual is triaged into an elevated risk group, the individual is subjected to a secondary test to determine likelihood of presence of disease.
 6. A method as claimed in claim 5 wherein the individual is a postmenopausal woman, the disease is ovarian cancer, the marker is CA125 and the secondary test is an ultrasonographic test.
 7. A method as claimed in claim 5 wherein, if the individual is triaged into the elevated risk group, the level of the marker is again detected and the risk is again computed.
 8. A method as claimed in claim 7 wherein, if results of the secondary test are equivocal, the secondary test is repeated and a course of action is determined based on results of the repeated test or recomputed risk.
 9. A method as claimed in claim 7 wherein, if the results of the secondary test are normal, a course of action is determined based on a recomputed risk.
 10. A method as claimed in claim 1 wherein the individual is a postmenopausal woman, the disease is ovarian cancer and the marker is CA125.
 11. A method as claimed in claim 10 wherein, if the individual is triaged into an elevated risk group, the individual is subjected to a secondary test of ultrasound examination to determine a course of action.
 12. A method as claimed in claim 10 wherein the individual is triaged to the borderline risk group if the risk of disease is computed to be in a range of 0.05 to 4%.
 13. The method of claim 1 wherein the risk of the disease is computed from a statistical analysis of the marker level distributions for tested normal and diseased populations.
 14. A method as claimed in claim 13 wherein the risk is determined from multivariate distributions.
 15. A method as claimed in claim 14 wherein the marker level changes exponentially over time for diseased individuals and the multivariate distributions are determined from the slope and intercept of the log of detected marker levels over time for individuals within the normal and diseased populations.
 16. The method of claim 14 wherein random draws are used to compute average densities from the normal and disease populations given the marker levels for the individual.
 17. A method as claimed in claim 16 wherein the risk is computed as a product of an odds factor and an estimate of prior odds, wherein the odds factor is the ratio of the average density from the disease population to the average density from the normal population.
 18. A method as claimed in claim 16 wherein the risk is determined through addition of a time correlation component to a linear regression model of marker levels.
 19. A method as claimed in claim 14 wherein the multivariate distribution is obtained by detecting plural markers.
 20. A method of assessing the risk of a woman for ovarian cancer, comprising:a) testing the woman to detect a level of a marker for ovarian cancer; b) computing risk of ovarian cancer from a detected level of the marker; and c) comparing the computed risk to thresholds to triage the woman into one of normal, borderline and elevated risk groups,wherein if the woman is triaged to a borderline risk group, the step of testing the woman to detect the level of the marker is repeated at a retest interval substantially less than a routine screening interval.
 21. A method as claimed in claim 20 wherein the marker level changes exponentially over time for diseased individuals and the multivariate distributions are determined from the slope and intercept of the log of detected marker levels over time for individuals within the normal and diseased populations.
 22. The method of claim 21 wherein random draws are used to compute average densities from the normal and disease populations given the marker levels for the individual.
 23. A method as claimed in claim 22 wherein the risk is computed as a product of the odds factor and an estimate of prior odds, wherein the odds factor is the ratio of the average density from the disease population to the average density from the normal population.
 24. A method as claimed in claim 21 wherein the risk is determined through addition of a time correlation component to a linear regression model of marker levels.
 25. A method as claimed in claim 20 wherein the multivariate distribution is obtained by detecting plural markers.
 26. A method of assessing the risk of an individual for a ovarian cancer comprising;testing the individual at plural times to detect a level of a marker to the disease; computing risk of ovarian cancer from a statistical analysis of detected marker levels relative to multivariate marker level distributions for tested normal and diseased populations; and determining a course of action for the individual based on the computed risk factor.
 27. A method as claimed in claim 26 wherein the marker level changes exponentially over time for diseased individuals and the multivariate distributions are determined from the slope and intercept of the log of detected marker levels over time for individuals within the normal and diseased populations.
 28. The method of claim 27 wherein random draws are used to compute average densities from the normal and disease populations given the marker levels for the individual.
 29. A method as claimed in claim 28 wherein the risk is computed as a product of the odds factor and an estimate of prior odds, wherein the odds factor is the ratio of the average density from the disease population to the average density from the normal population.
 30. A method as claimed in claim 27 wherein the risk is determined through addition of a time correlation component to a linear regression model of marker levels.
 31. A method as claimed in claim 26 wherein the multivariate distribution is obtained by detecting plural markers. 